Bus Knoxville, TN to Indianapolis: Compare prices and save money

Compare all timetables for the bus from Knoxville, TN to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to Indianapolis from various bus operators like Greyhound US for the next days.

today

$67

tomorrow

$69

Wednesday

Thursday

Friday

$71

Saturday

$73

Sunday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	10h 45m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	4:55 AM	Indianapolis	Central Bus Station	Economy	$67	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/27/2026 6:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/28/2026 4:55:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 10h 45m
Greyhound US	16h 10m	8:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	12:10 PM	Indianapolis	Central Bus Station	Economy	$67	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/27/2026 8:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/28/2026 12:10:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 16h 10m
Greyhound US	13h 50m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:00 AM	Indianapolis	Downtown Transit Center	Economy	$75	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/27/2026 6:10:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 7/28/2026 8:00:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 50m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	16h 10m	8:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	12:10 PM	Indianapolis	Central Bus Station		Economy	$69	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/28/2026 8:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/29/2026 12:10:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 16h 10m
	Greyhound US	10h 45m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	4:55 AM	Indianapolis	Central Bus Station		Economy	$72	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/28/2026 6:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/29/2026 4:55:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 10h 45m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 50m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:00 AM	Indianapolis	Washington / Delaware	Economy	$71	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/31/2026 6:10:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 8/1/2026 8:00:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 13h 50m
Greyhound US	10h 45m	6:10 PM	Knoxville, TN	Greyhound Bus Station	4:55 AM	Indianapolis	Central Bus Station	Economy	$71	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/31/2026 6:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/1/2026 4:55:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 10h 45m
Greyhound US	16h 10m	8:00 PM	Knoxville, TN	Greyhound Bus Station	12:10 PM	Indianapolis	Central Bus Station	Economy	$71	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/31/2026 8:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/1/2026 12:10:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 16h 10m

Did you know that if you travel from Knoxville, TN to Indianapolis via Trotwood, OH, you can save more than $10? You can find the corresponding connections below.
- Greyhound US
  
  15h 15m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  5:40 AM
  
  Trotwood, OH
  Bus Stop
  
  0
  
  Economy
  
  $44
  
  A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/30/2026 10:00:00 PM to Bus Stop, Trotwood, OH (USA) arriving at 7/31/2026 5:40:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 7h 40m
- FlixBus
  
  1h 50m
  
  0
  
  11:25 AM
  
  Trotwood, OH
  Bus Stop
  
  1:15 PM
  
  Indianapolis
  Downtown Transit Center
  
  0
  
  Economy
  
  $17
  
  A Bus from FlixBus goes from Bus Stop, Trotwood, OH (USA) at 7/31/2026 11:25:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 7/31/2026 1:15:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 50m
Travel time is 4h 30m longer, but you will save $10

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 50m	6:10 PM	Knoxville, TN	Greyhound Bus Station	8:00 AM	Indianapolis	Washington / Delaware	Economy	$73	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/1/2026 6:10:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 8/2/2026 8:00:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 13h 50m
Greyhound US	10h 45m	6:10 PM	Knoxville, TN	Greyhound Bus Station	4:55 AM	Indianapolis	Central Bus Station	Economy	$73	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/1/2026 6:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/2/2026 4:55:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 10h 45m
Greyhound US	16h 10m	8:00 PM	Knoxville, TN	Greyhound Bus Station	12:10 PM	Indianapolis	Central Bus Station	Economy	$73	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 8/1/2026 8:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/2/2026 12:10:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 16h 10m

Did you know that if you travel from Knoxville, TN to Indianapolis via Trotwood, OH, you can save more than $12? You can find the corresponding connections below.
- Greyhound US
  
  15h 15m
  
  0
  
  10:00 PM
  
  Knoxville, TN
  Knoxville Area Transit Bus Stop
  
  5:40 AM
  
  Trotwood, OH
  Bus Stop
  
  0
  
  Economy
  
  $44
  
  A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/30/2026 10:00:00 PM to Bus Stop, Trotwood, OH (USA) arriving at 7/31/2026 5:40:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 7h 40m
- FlixBus
  
  1h 50m
  
  0
  
  11:25 AM
  
  Trotwood, OH
  Bus Stop
  
  1:15 PM
  
  Indianapolis
  Downtown Transit Center
  
  0
  
  Economy
  
  $17
  
  A Bus from FlixBus goes from Bus Stop, Trotwood, OH (USA) at 7/31/2026 11:25:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 7/31/2026 1:15:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 50m
Travel time is 4h 30m longer, but you will save $12

Test cheapest views

The cheapest bus for the 7/27/2026 costs just $67, from Greyhound US

Facts about the bus from Knoxville, TN to Indianapolis

Compare all providers like Greyhound US that travel 2 times every day by bus from Knoxville, TN to Indianapolis in one click! Book your bus ticket from Knoxville, TN to Indianapolis starting from $67!

Cheapest Bus	$67
Fastest Bus	10h 45m
Earliest Bus	6:10 PM
Latest Bus	8:00 PM
Daily Bus Routes	2 Ø
Distance	289.8 miles
Bus Companies	Greyhound US

Cheapest bus connections from Knoxville, TN to Indianapolis

Every day, 2 buses from 1 bus companies leave Knoxville, TN for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/27/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

Monday 07/27

$67

Tuesday 07/28

$69

Wednesday 07/29

$74

Thursday 07/30

Friday 07/31

$71

Saturday 08/01

$73

Sunday 08/02

Monday 08/03

$72

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

Friday 08/07

$67

Saturday 08/08

Sunday 08/09

$78

Monday 08/10

Tuesday 08/11

Wednesday 08/12

$74

Thursday 08/13

Friday 08/14

Saturday 08/15

Sunday 08/16

Monday 08/17

Tuesday 08/18

$70

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

How to save money travelling from Knoxville, TN to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Indianapolis are also emptier.

All bus stations and stops in Knoxville, TN and Indianapolis

In the map below, you can see where to find all bus stations in Knoxville, TN and Indianapolis.

Kingston Pike

Kingston Pike 6927

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Transit Center

E Church Ave 301

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from Knoxville, TN to Indianapolis

Want to know which seat classes are available on the buses from Knoxville, TN to Indianapolis? Or which bus companies serve the route Knoxville, TN to Indianapolis? Below you will find answers to your questions.

FAQs about the Knoxville, TN to Indianapolis bus

How much does a Knoxville, TN Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $67 and takes 10h 45m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $67 and $75. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Knoxville, TN to Indianapolis each day?

Every day, the Knoxville, TN to Indianapolis bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to Indianapolis take?

The fastest bus from Knoxville, TN to Indianapolis is offered by Greyhound US and takes 10h 45m. Bus tickets for this connection cost $67. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to Indianapolis?

The earliest bus arriving in Indianapolis from Knoxville, TN starts at 6:10 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to Indianapolis?

The latest bus trip departing from Knoxville, TN for Indianapolis starts at 8:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN Indianapolis route?

When traveling by bus from Knoxville, TN to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and Indianapolis?

You can check all the direct connections between Knoxville, TN and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route Knoxville, TN to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to Indianapolis

Here’s an overview of the most popular bus routes to Knoxville, TN and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!