Bus San Diego to Indianapolis: Compare prices and save money

Compare all timetables for the bus from San Diego to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Diego to Indianapolis from various bus operators like FlixBus or Greyhound US for the next days.

today

$166

tomorrow

$137

Monday

$144

Tuesday

$152

Wednesday

$166

Thursday

$156

Friday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	54h 0m	7:55 PM	San Diego	Old Town Transit Center	4:55 AM	Indianapolis	Central Bus Station		Economy	$166	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/25/2026 7:55:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/28/2026 4:55:00 AM. 50 Economy ticket for $166 per person are available. Travel duration is 54h 0m
	Greyhound US	57h 5m	7:55 PM	San Diego	Old Town Transit Center	8:00 AM	Indianapolis	Downtown Transit Center		Economy	$175	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/25/2026 7:55:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 7/28/2026 8:00:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 57h 5m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	49h 40m	9:50 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$137	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/26/2026 9:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/28/2026 2:30:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 49h 40m
FlixBus	55h 5m	1:10 PM	San Diego	Seaport Village	11:15 PM	Indianapolis	Downtown Transit Center	Economy	$141	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 7/26/2026 1:10:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 7/28/2026 11:15:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 55h 5m
FlixBus	58h 50m	9:25 AM	San Diego	Old Town Transit Center	11:15 PM	Indianapolis	Downtown Transit Center	Economy	$142	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/26/2026 9:25:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 7/28/2026 11:15:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 58h 50m
Greyhound US	54h 0m	7:55 PM	San Diego	Old Town Transit Center	4:55 AM	Indianapolis	Central Bus Station	Economy	$146	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/26/2026 7:55:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/29/2026 4:55:00 AM. 50 Economy ticket for $146 per person are available. Travel duration is 54h 0m
Greyhound US	56h 55m	9:50 AM	San Diego	Old Town Transit Center	9:45 PM	Indianapolis	Downtown Transit Center	Economy	$147	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/26/2026 9:50:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 7/28/2026 9:45:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 56h 55m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	55h 5m	1:10 PM	San Diego	Seaport Village	11:15 PM	Indianapolis	Downtown Transit Center	Economy	$144	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 7/27/2026 1:10:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 7/29/2026 11:15:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 55h 5m
Greyhound US	56h 55m	9:50 AM	San Diego	Old Town Transit Center	9:45 PM	Indianapolis	Downtown Transit Center	Economy	$144	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/27/2026 9:50:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 7/29/2026 9:45:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 56h 55m
FlixBus	58h 50m	9:25 AM	San Diego	Old Town Transit Center	11:15 PM	Indianapolis	Downtown Transit Center	Economy	$145	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/27/2026 9:25:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 7/29/2026 11:15:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 58h 50m
FlixBus	59h 10m	7:35 AM	San Diego	Old Town Transit Center	9:45 PM	Indianapolis	Downtown Transit Center	Economy	$147	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/27/2026 7:35:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 7/29/2026 9:45:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 59h 10m
Greyhound US	57h 5m	7:55 PM	San Diego	Old Town Transit Center	8:00 AM	Indianapolis	Downtown Transit Center	Economy	$163	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/27/2026 7:55:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 7/30/2026 8:00:00 AM. 50 Economy ticket for $163 per person are available. Travel duration is 57h 5m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 10m	1:10 PM	San Diego	Seaport Village	7:20 PM	Indianapolis	Central Bus Station	Economy	$152	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 7/28/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 7:20:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 51h 10m
FlixBus	54h 55m	9:25 AM	San Diego	Old Town Transit Center	7:20 PM	Indianapolis	Central Bus Station	Economy	$154	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/28/2026 9:25:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 7:20:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 54h 55m
FlixBus	50h 45m	1:35 PM	San Diego	La Jolla Village	7:20 PM	Indianapolis	Central Bus Station	Economy	$154	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 7/28/2026 1:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 7:20:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 50h 45m
Greyhound US	56h 55m	9:50 AM	San Diego	Old Town Transit Center	9:45 PM	Indianapolis	Washington / Delaware	Economy	$156	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/28/2026 9:50:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 7/30/2026 9:45:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 56h 55m
Greyhound US	54h 0m	7:55 PM	San Diego	Old Town Transit Center	4:55 AM	Indianapolis	Central Bus Station	Economy	$161	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/28/2026 7:55:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/31/2026 4:55:00 AM. 50 Economy ticket for $161 per person are available. Travel duration is 54h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 10m	1:10 PM	San Diego	Seaport Village	7:20 PM	Indianapolis	Central Bus Station	Economy	$166	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 7/29/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/31/2026 7:20:00 PM. 50 Economy ticket for $166 per person are available. Travel duration is 51h 10m
FlixBus	54h 55m	9:25 AM	San Diego	Old Town Transit Center	7:20 PM	Indianapolis	Central Bus Station	Economy	$167	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/29/2026 9:25:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/31/2026 7:20:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 54h 55m
FlixBus	50h 45m	1:35 PM	San Diego	La Jolla Village	7:20 PM	Indianapolis	Central Bus Station	Economy	$170	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 7/29/2026 1:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/31/2026 7:20:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 50h 45m
Greyhound US	49h 40m	9:50 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$179	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/29/2026 9:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/31/2026 2:30:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 49h 40m
Greyhound US	58h 25m	9:50 AM	San Diego	Old Town Transit Center	11:15 PM	Indianapolis	Downtown Transit Center	Economy	$184	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/29/2026 9:50:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 7/31/2026 11:15:00 PM. 50 Economy ticket for $184 per person are available. Travel duration is 58h 25m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	55h 5m	1:10 PM	San Diego	Seaport Village	11:15 PM	Indianapolis	Downtown Transit Center	Economy	$156	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 7/30/2026 1:10:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 8/1/2026 11:15:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 55h 5m
FlixBus	58h 50m	9:25 AM	San Diego	Old Town Transit Center	11:15 PM	Indianapolis	Downtown Transit Center	Economy	$158	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/30/2026 9:25:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 8/1/2026 11:15:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 58h 50m
FlixBus	51h 10m	1:10 PM	San Diego	Seaport Village	7:20 PM	Indianapolis	Central Bus Station	Economy	$176	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 7/30/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/1/2026 7:20:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 51h 10m
Greyhound US	56h 55m	9:50 AM	San Diego	Old Town Transit Center	9:45 PM	Indianapolis	Downtown Transit Center	Economy	$181	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/30/2026 9:50:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 8/1/2026 9:45:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 56h 55m
Greyhound US	54h 0m	7:55 PM	San Diego	Old Town Transit Center	4:55 AM	Indianapolis	Central Bus Station	Economy	$187	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/30/2026 7:55:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/2/2026 4:55:00 AM. 50 Economy ticket for $187 per person are available. Travel duration is 54h 0m

Frequency of bus connections between San Diego and Indianapolis

See here how frequent the connections between San Diego and Indianapolis are, during different times and days of the week.

Wednesday is the busiest day, with more than 21 daily buses from San Diego to Indianapolis. Saturday has instead the fewest connections, with only 2 daily coaches between San Diego and Indianapolis.

The busiest time of the day is the Morning, with 37 buses from San Diego to Indianapolis, while Evening sees the fewest connections between San Diego and Indianapolis, with 14 offers.

Test cheapest views

The cheapest bus for the 7/26/2026 costs just $137, from Greyhound US

Facts about the bus from San Diego to Indianapolis

Compare all providers like FlixBus and Greyhound US that travel 11 times every day by bus from San Diego to Indianapolis in one click! Book your bus ticket from San Diego to Indianapolis starting from $137!

Cheapest Bus	$137
Fastest Bus	52h 40m
Earliest Bus	7:55 PM
Latest Bus	7:55 PM
Daily Bus Routes	11 Ø
Distance	1,785.2 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Indianapolis

Every day, 11 buses from 2 bus companies leave San Diego for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

$146

Sunday 07/26

$137

Monday 07/27

$144

Tuesday 07/28

$152

Wednesday 07/29

$170

Thursday 07/30

$156

Friday 07/31

Saturday 08/01

$161

Sunday 08/02

$148

Monday 08/03

$145

Tuesday 08/04

$142

Wednesday 08/05

$144

Thursday 08/06

$175

Friday 08/07

Saturday 08/08

Sunday 08/09

$165

Monday 08/10

$190

Tuesday 08/11

Wednesday 08/12

$161

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from San Diego to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Indianapolis, for the next 30 days.

With a price starting from $137, Sunday is the cheapest day for a bus from San Diego to Indianapolis. Thursday instead is the most expensive day with prices starting from $156.

Morning is the cheapest day time for bus tickets from San Diego to Indianapolis, with $137. Evening is the most expensive time of the day with prices starting from $146.

How to save money travelling from San Diego to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Indianapolis are also emptier.

All bus stations and stops in San Diego and Indianapolis

In the map below, you can see where to find all bus stations in San Diego and Indianapolis.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

Downtown

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from San Diego to Indianapolis

Want to know which seat classes are available on the buses from San Diego to Indianapolis? Or which bus companies serve the route San Diego to Indianapolis? Below you will find answers to your questions.

FAQs about the San Diego to Indianapolis bus

How much does a San Diego Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $137 and takes 52h 40m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Diego to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $137 and $210. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Diego to Indianapolis each day?

Every day, the San Diego to Indianapolis bus route is served by approximately 11 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Indianapolis take?

The fastest bus from San Diego to Indianapolis is offered by Greyhound US and takes 52h 40m. Bus tickets for this connection cost $137. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Indianapolis?

The earliest bus arriving in Indianapolis from San Diego starts at 7:55 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Indianapolis?

The latest bus trip departing from San Diego for Indianapolis starts at 7:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Indianapolis route?

When traveling by bus from San Diego to Indianapolis, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Indianapolis?

You can check all the direct connections between San Diego and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route San Diego to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Indianapolis

Here’s an overview of the most popular bus routes to San Diego and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!