Bus San Francisco to Indianapolis: Compare prices and save money

Compare all timetables for the bus from San Francisco to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Francisco to Indianapolis from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

$147

Wednesday

Thursday

Friday

$132

Saturday

$140

Sunday

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	56h 50m	7:30 AM	San Francisco	5th/Townsend	7:20 PM	Indianapolis	Central Bus Station	Economy	$147	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 7/28/2026 7:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 7:20:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 56h 50m
FlixBus	64h 55m	11:25 PM	San Francisco	5th/Townsend	7:20 PM	Indianapolis	Central Bus Station	Economy	$152	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 7/28/2026 11:25:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/31/2026 7:20:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 64h 55m
Greyhound US	50h 50m	1:30 PM	San Francisco	Bus Station Transbay	7:20 PM	Indianapolis	Central Bus Station	Economy	$154	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 7/28/2026 1:30:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 7:20:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 50h 50m
FlixBus	61h 35m	7:30 AM	San Francisco	5th/Townsend	12:05 AM	Indianapolis	Washington / Delaware	Economy	$157	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 7/28/2026 7:30:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 7/31/2026 12:05:00 AM. 50 Economy ticket for $157 per person are available. Travel duration is 61h 35m
Greyhound US	55h 35m	1:30 PM	San Francisco	Bus Station Transbay	12:05 AM	Indianapolis	Washington / Delaware	Economy	$162	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 7/28/2026 1:30:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 7/31/2026 12:05:00 AM. 50 Economy ticket for $162 per person are available. Travel duration is 55h 35m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	50h 50m	1:30 PM	San Francisco	Bus Station Transbay	7:20 PM	Indianapolis	Central Bus Station	Economy	$132	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 7/31/2026 1:30:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/2/2026 7:20:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 50h 50m
FlixBus	67h 20m	11:25 PM	San Francisco	5th/Townsend	9:45 PM	Indianapolis	Washington / Delaware	Economy	$158	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 7/31/2026 11:25:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 8/3/2026 9:45:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 67h 20m
FlixBus	60h 5m	11:25 PM	San Francisco	5th/Townsend	2:30 PM	Indianapolis	Central Bus Station	Economy	$160	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 7/31/2026 11:25:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/3/2026 2:30:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 60h 5m
Greyhound US	54h 45m	1:30 PM	San Francisco	Bus Station Transbay	11:15 PM	Indianapolis	Washington / Delaware	Economy	$166	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 7/31/2026 1:30:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 8/2/2026 11:15:00 PM. 50 Economy ticket for $166 per person are available. Travel duration is 54h 45m
Greyhound US	68h 15m	10:30 PM	San Francisco	Bus Station Transbay	9:45 PM	Indianapolis	Washington / Delaware	Economy	$170	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 7/31/2026 10:30:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 8/3/2026 9:45:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 68h 15m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	54h 45m	1:30 PM	San Francisco	Bus Station Transbay	11:15 PM	Indianapolis	Washington / Delaware	Economy	$140	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 8/1/2026 1:30:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 8/3/2026 11:15:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 54h 45m
FlixBus	64h 55m	11:25 PM	San Francisco	5th/Townsend	7:20 PM	Indianapolis	Central Bus Station	Economy	$142	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 8/1/2026 11:25:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/4/2026 7:20:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 64h 55m
Greyhound US	50h 50m	1:30 PM	San Francisco	Bus Station Transbay	7:20 PM	Indianapolis	Central Bus Station	Economy	$143	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 8/1/2026 1:30:00 PM to Central Bus Station, Indianapolis (USA) arriving at 8/3/2026 7:20:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 50h 50m
FlixBus	68h 50m	11:25 PM	San Francisco	5th/Townsend	11:15 PM	Indianapolis	Washington / Delaware	Economy	$151	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 8/1/2026 11:25:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 8/4/2026 11:15:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 68h 50m
Greyhound US	68h 15m	10:30 PM	San Francisco	Bus Station Transbay	9:45 PM	Indianapolis	Washington / Delaware	Economy	$176	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 8/1/2026 10:30:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 8/4/2026 9:45:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 68h 15m

Frequency of bus connections between San Francisco and Indianapolis

See here how frequent the connections between San Francisco and Indianapolis are, during different times and days of the week.

Tuesday is the busiest day, with more than 8 daily buses from San Francisco to Indianapolis. Friday has instead the fewest connections, with only 6 daily coaches between San Francisco and Indianapolis.

The busiest time of the day is the Evening, with 12 buses from San Francisco to Indianapolis, while Morning sees the fewest connections between San Francisco and Indianapolis, with 2 offers.

Test cheapest views

The cheapest bus for the 7/31/2026 costs just $132, from Greyhound US

Facts about the bus from San Francisco to Indianapolis

Compare all providers like Greyhound US and FlixBus that travel 6 times every day by bus from San Francisco to Indianapolis in one click! Book your bus ticket from San Francisco to Indianapolis starting from $132!

Cheapest Bus	$132
Fastest Bus	53h 50m
Earliest Bus	7:30 AM
Latest Bus	11:25 PM
Daily Bus Routes	6 Ø
Distance	1,944.5 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from San Francisco to Indianapolis

Every day, 6 buses from 2 bus companies leave San Francisco for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/27/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

Monday 07/27

Tuesday 07/28

$147

Wednesday 07/29

Thursday 07/30

Friday 07/31

$132

Saturday 08/01

$140

Sunday 08/02

Monday 08/03

$135

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

Friday 08/07

$133

Saturday 08/08

Sunday 08/09

Monday 08/10

Tuesday 08/11

$177

Wednesday 08/12

$156

Thursday 08/13

Friday 08/14

Saturday 08/15

Sunday 08/16

Monday 08/17

Tuesday 08/18

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

The cheapest time to travel from San Francisco to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Francisco to Indianapolis, for the next 30 days.

With a price starting from $132, Friday is the cheapest day for a bus from San Francisco to Indianapolis. Tuesday instead is the most expensive day with prices starting from $147.

Afternoon is the cheapest day time for bus tickets from San Francisco to Indianapolis, with $132. Morning is the most expensive time of the day with prices starting from $147.

How to save money travelling from San Francisco to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Francisco to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Francisco to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Francisco to Indianapolis are also emptier.

All bus stations and stops in San Francisco and Indianapolis

In the map below, you can see where to find all bus stations in San Francisco and Indianapolis.

South Van Ness Ave & Market St

5th/Townsend

Townsend St 400

Bus Station Transbay

Folsom Street 200

Union Square

Post St 470

Beach St & Hyde St

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from San Francisco to Indianapolis

Want to know which seat classes are available on the buses from San Francisco to Indianapolis? Or which bus companies serve the route San Francisco to Indianapolis? Below you will find answers to your questions.

FAQs about the San Francisco to Indianapolis bus

How much does a San Francisco Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $132 and takes 53h 50m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Francisco to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $132 and $183. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Francisco to Indianapolis each day?

Every day, the San Francisco to Indianapolis bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Francisco to Indianapolis take?

The fastest bus from San Francisco to Indianapolis is offered by Greyhound US and takes 53h 50m. Bus tickets for this connection cost $154. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Francisco to Indianapolis?

The earliest bus arriving in Indianapolis from San Francisco starts at 7:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Francisco to Indianapolis?

The latest bus trip departing from San Francisco for Indianapolis starts at 11:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Francisco Indianapolis route?

When traveling by bus from San Francisco to Indianapolis, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Francisco and Indianapolis?

You can check all the direct connections between San Francisco and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the San Francisco to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Francisco Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Francisco Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Francisco to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route San Francisco to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Francisco and to Indianapolis

Here’s an overview of the most popular bus routes to San Francisco and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!