Bus Siena to Milan: Compare prices and save money

Compare all timetables for the bus from Siena to Milan

Here is a selection of the cheapest bus trips from the schedule from Siena to Milan from various bus operators like FlixBus or Itabus for the next days.

today

$21

tomorrow

$12

Tuesday

$12

Wednesday

$19

Thursday

$10

Friday

$20

Saturday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	5h 45m	10:55 AM	Siena	Central Bus Station	4:40 PM	Milan	Lampugnano Bus Station	Economy	$21	A Bus from Itabus goes from Central Bus Station, Siena (Italy) at 7/26/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/26/2026 4:40:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 5h 45m
FlixBus	5h 19m	6:40 PM	Siena	Train Station	11:59 PM	Milan	Lampugnano Bus Station	Economy	$26	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/26/2026 6:40:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 7/26/2026 11:59:00 PM. 50 Economy ticket for $26 per person are available. Travel duration is 5h 19m
FlixBus	6h 10m	5:25 PM	Siena	Train Station	11:35 PM	Milan	Lampugnano Bus Station	Economy	$27	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/26/2026 5:25:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 7/26/2026 11:35:00 PM. 50 Economy ticket for $27 per person are available. Travel duration is 6h 10m
FlixBus	4h 50m	4:05 PM	Siena	Train Station	8:55 PM	Milan	San Donato Bus Station	Economy	$30	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/26/2026 4:05:00 PM to San Donato Bus Station, Milan (Italy) arriving at 7/26/2026 8:55:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 4h 50m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	5h 45m	10:55 AM	Siena	Train Station	4:40 PM	Milan	Lampugnano Bus Station	Premium Economy	$12	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/27/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/27/2026 4:40:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 5h 45m
Itabus	4h 55m	1:55 PM	Siena	Train Station	6:50 PM	Milan	San Donato Bus Station	Premium Economy	$19	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/27/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 7/27/2026 6:50:00 PM. 50 Premium Economy ticket for $19 per person are available. Travel duration is 4h 55m
FlixBus	5h 50m	6:10 AM	Siena	Train Station	12:00 PM	Milan	San Donato Bus Station	Economy	$21	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/27/2026 6:10:00 AM to San Donato Bus Station, Milan (Italy) arriving at 7/27/2026 12:00:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 5h 50m
FlixBus	4h 50m	6:40 AM	Siena	Train Station	11:30 AM	Milan	San Donato Bus Station	Economy	$21	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/27/2026 6:40:00 AM to San Donato Bus Station, Milan (Italy) arriving at 7/27/2026 11:30:00 AM. 50 Economy ticket for $21 per person are available. Travel duration is 4h 50m
FlixBus	6h 50m	6:10 AM	Siena	Train Station	1:00 PM	Milan	Lampugnano Bus Station	Economy	$21	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/27/2026 6:10:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/27/2026 1:00:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 6h 50m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Itabus	5h 45m	10:55 AM	Siena	Train Station	4:40 PM	Milan	Lampugnano Bus Station		Premium Economy	$12	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/28/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/28/2026 4:40:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 5h 45m
	Itabus	7h 30m	1:55 PM	Siena	Train Station	9:25 PM	Milan	Lampugnano Bus Station		Premium Economy	$23	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/28/2026 1:55:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 7/28/2026 9:25:00 PM. 50 Premium Economy ticket for $23 per person are available. Travel duration is 7h 30m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	5h 45m	10:55 AM	Siena	Train Station	4:40 PM	Milan	Lampugnano Bus Station	Premium Economy	$19	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/29/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/29/2026 4:40:00 PM. 50 Premium Economy ticket for $19 per person are available. Travel duration is 5h 45m
Itabus	4h 55m	1:55 PM	Siena	Train Station	6:50 PM	Milan	San Donato Bus Station	Premium Economy	$19	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/29/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 7/29/2026 6:50:00 PM. 50 Premium Economy ticket for $19 per person are available. Travel duration is 4h 55m
FlixBus	5h 19m	6:40 PM	Siena	Train Station	11:59 PM	Milan	Lampugnano Bus Station	Economy	$21	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/29/2026 6:40:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 7/29/2026 11:59:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 5h 19m
FlixBus	5h 40m	12:15 PM	Siena	Train Station	5:55 PM	Milan	Lampugnano Bus Station	Economy	$22	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/29/2026 12:15:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 7/29/2026 5:55:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 5h 40m
FlixBus	5h 55m	7:50 AM	Siena	Train Station	1:45 PM	Milan	Lampugnano Bus Station	Economy	$23	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/29/2026 7:50:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/29/2026 1:45:00 PM. 50 Economy ticket for $23 per person are available. Travel duration is 5h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	5h 45m	10:55 AM	Siena	Train Station	4:40 PM	Milan	Lampugnano Bus Station	Premium Economy	$10	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/30/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/30/2026 4:40:00 PM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 5h 45m
FlixBus	4h 50m	4:05 PM	Siena	Train Station	8:55 PM	Milan	San Donato Bus Station	Economy	$18	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/30/2026 4:05:00 PM to San Donato Bus Station, Milan (Italy) arriving at 7/30/2026 8:55:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 4h 50m
Itabus	4h 55m	1:55 PM	Siena	Train Station	6:50 PM	Milan	San Donato Bus Station	Premium Economy	$19	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/30/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 7/30/2026 6:50:00 PM. 50 Premium Economy ticket for $19 per person are available. Travel duration is 4h 55m
FlixBus	5h 50m	6:10 AM	Siena	Train Station	12:00 PM	Milan	San Donato Bus Station	Economy	$20	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/30/2026 6:10:00 AM to San Donato Bus Station, Milan (Italy) arriving at 7/30/2026 12:00:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 5h 50m
FlixBus	6h 50m	6:10 AM	Siena	Train Station	1:00 PM	Milan	Lampugnano Bus Station	Economy	$20	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/30/2026 6:10:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/30/2026 1:00:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 6h 50m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	5h 45m	10:55 AM	Siena	Train Station	4:40 PM	Milan	Lampugnano Bus Station	Premium Economy	$20	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/31/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/31/2026 4:40:00 PM. 50 Premium Economy ticket for $20 per person are available. Travel duration is 5h 45m
Itabus	5h 50m	1:05 AM	Siena	Train Station	6:55 AM	Milan	Lampugnano Bus Station	Premium Economy	$23	A Bus from Itabus goes from Train Station, Siena (Italy) at 7/31/2026 1:05:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 7/31/2026 6:55:00 AM. 50 Premium Economy ticket for $23 per person are available. Travel duration is 5h 50m
FlixBus	4h 50m	4:05 PM	Siena	Train Station	8:55 PM	Milan	San Donato Bus Station	Economy	$24	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/31/2026 4:05:00 PM to San Donato Bus Station, Milan (Italy) arriving at 7/31/2026 8:55:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 50m
FlixBus	7h 20m	2:25 PM	Siena	Train Station	9:45 PM	Milan	Lampugnano Bus Station	Economy	$25	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/31/2026 2:25:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 7/31/2026 9:45:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 7h 20m
FlixBus	4h 50m	6:40 AM	Siena	Train Station	11:30 AM	Milan	San Donato Bus Station	Economy	$26	A Bus from FlixBus goes from Train Station, Siena (Italy) at 7/31/2026 6:40:00 AM to San Donato Bus Station, Milan (Italy) arriving at 7/31/2026 11:30:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 4h 50m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	5h 45m	10:55 AM	Siena	Train Station	4:40 PM	Milan	Lampugnano Bus Station	Premium Economy	$9	A Bus from Itabus goes from Train Station, Siena (Italy) at 8/1/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 8/1/2026 4:40:00 PM. 50 Premium Economy ticket for $9 per person are available. Travel duration is 5h 45m
Itabus	4h 55m	1:55 PM	Siena	Train Station	6:50 PM	Milan	San Donato Bus Station	Premium Economy	$20	A Bus from Itabus goes from Train Station, Siena (Italy) at 8/1/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 8/1/2026 6:50:00 PM. 50 Premium Economy ticket for $20 per person are available. Travel duration is 4h 55m
Itabus	7h 30m	1:55 PM	Siena	Train Station	9:25 PM	Milan	Lampugnano Bus Station	Premium Economy	$24	A Bus from Itabus goes from Train Station, Siena (Italy) at 8/1/2026 1:55:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 8/1/2026 9:25:00 PM. 50 Premium Economy ticket for $24 per person are available. Travel duration is 7h 30m
Itabus	5h 50m	1:05 AM	Siena	Train Station	6:55 AM	Milan	Lampugnano Bus Station	Premium Economy	$28	A Bus from Itabus goes from Train Station, Siena (Italy) at 8/1/2026 1:05:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 8/1/2026 6:55:00 AM. 50 Premium Economy ticket for $28 per person are available. Travel duration is 5h 50m
Itabus	6h 55m	10:55 AM	Siena	Piazza Antonio Gramsci	5:50 PM	Milan	Lampugnano Bus Station	Economy	$28	A Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 8/1/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 8/1/2026 5:50:00 PM. 50 Economy ticket for $28 per person are available. Travel duration is 6h 55m

Frequency of bus connections between Siena and Milan

See here how frequent the connections between Siena and Milan are, during different times and days of the week.

Thursday is the busiest day, with more than 32 daily buses from Siena to Milan. Tuesday has instead the fewest connections, with only 4 daily coaches between Siena and Milan.

The busiest time of the day is the Morning, with 57 buses from Siena to Milan, while Evening sees the fewest connections between Siena and Milan, with 4 offers.

Test cheapest views

The cheapest bus for the 8/1/2026 costs just $9, from Itabus

Facts about the bus from Siena to Milan

Compare all providers like FlixBus and Itabus that travel 20 times every day by bus from Siena to Milan in one click! Book your bus ticket from Siena to Milan starting from $9!

Cheapest Bus	$9
Fastest Bus	4h 30m
Earliest Bus	12:45 AM
Latest Bus	1:55 PM
Daily Bus Routes	20 Ø
Distance	182.3 miles
Bus Companies	FlixBus and Itabus

Cheapest bus connections from Siena to Milan

Every day, 20 buses from 2 bus companies leave Siena for Milan: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

$26

Monday 07/27

$13

Tuesday 07/28

$21

Wednesday 07/29

$13

Thursday 07/30

$11

Friday 07/31

$15

Saturday 08/01

Sunday 08/02

$18

Monday 08/03

$15

Tuesday 08/04

Wednesday 08/05

$13

Thursday 08/06

$13

Friday 08/07

$23

Saturday 08/08

$35

Sunday 08/09

$23

Monday 08/10

$52

Tuesday 08/11

$18

Wednesday 08/12

$13

Thursday 08/13

Friday 08/14

Saturday 08/15

Sunday 08/16

$16

Monday 08/17

$36

Tuesday 08/18

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

The cheapest time to travel from Siena to Milan

See here on which day and which time of the day you can find the cheapest bus ticket from Siena to Milan, for the next 30 days.

With a price starting from $9, Saturday is the cheapest day for a bus from Siena to Milan. Sunday instead is the most expensive day with prices starting from $16.

Morning is the cheapest day time for bus tickets from Siena to Milan, with $9. Evening is the most expensive time of the day with prices starting from $21.

How to save money travelling from Siena to Milan

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Siena to Milan in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Siena to Milan, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Siena to Milan are also emptier.

All bus stations and stops in Siena and Milan

In the map below, you can see where to find all bus stations in Siena and Milan.

Piazza Antonio Gramsci

Central Bus Station

Bus Stop

Viale Pietro Toselli 9

Colonna San Marco

Lampugnano Bus Station

Via Giulio Natta Lampugnano

Rogoredo Bus Station

Via Cassinis Giovanni Battista 76

San Donato Bus Station

Via Giuseppe Impastato 25

Central Bus Station

Duomo Bus Stop

Piazza del Duomo

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Siena to Milan? Compare all modes of transports from Siena to Milan.

Service and Comfort on the bus from Siena to Milan

Want to know which seat classes are available on the buses from Siena to Milan? Or which bus companies serve the route Siena to Milan? Below you will find answers to your questions.

FAQs about the Siena to Milan bus

How much does a Siena Milan bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $9 and takes 5h 45m to reach Milan. Compare offers to save money!

How much could I save by comparing buses from Siena to Milan?

This route is offered by 2 companies with a range of ticket prices between $9 and $76. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Milan.

On average, how many connections are available from Siena to Milan each day?

Every day, the Siena to Milan bus route is served by approximately 20 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Siena to Milan take?

The fastest bus from Siena to Milan is offered by FlixBus and takes 4h 30m. Bus tickets for this connection cost $42. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Siena to Milan?

The earliest bus arriving in Milan from Siena starts at 12:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Siena to Milan?

The latest bus trip departing from Siena for Milan starts at 1:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Siena Milan route?

When traveling by bus from Siena to Milan, passengers can travel with FlixBus and Itabus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Siena and Milan?

You can check all the direct connections between Siena and Milan by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Itabus.

What can I take with me on the Siena to Milan bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Siena Milan bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Siena Milan bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Siena to Milan on your planned travel date.

Available seat classes which are offered on the bus route Siena to Milan

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Siena and to Milan

Here’s an overview of the most popular bus routes to Siena and to Milan. Simply click on the connection of your choice, and you will find all the details about your bus route!