Bus Indianapolis to San Diego - Compare all Companies

Compare all timetables for the bus from Indianapolis to San Diego

Here is a selection of the cheapest bus trips from the schedule from Indianapolis to San Diego from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

$132

Monday

$129

Tuesday

$147

Wednesday

$151

Thursday

$164

Friday

$167

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	56h 20m	11:05 AM	Indianapolis	Central Bus Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$132	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/26/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/28/2026 4:25:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 56h 20m
FlixBus	55h 15m	1:30 PM	Indianapolis	Downtown Transit Center	5:45 PM	San Diego	Old Town Transit Center	Economy	$134	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/26/2026 1:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/28/2026 5:45:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 55h 15m
FlixBus	55h 40m	1:30 PM	Indianapolis	Downtown Transit Center	6:10 PM	San Diego	Old Town Transit Center	Economy	$135	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/26/2026 1:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/28/2026 6:10:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 55h 40m
Greyhound US	49h 10m	7:35 PM	Indianapolis	Central Bus Station	5:45 PM	San Diego	Old Town Transit Center	Economy	$135	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/26/2026 7:35:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/28/2026 5:45:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 49h 10m
Greyhound US	53h 40m	7:35 PM	Indianapolis	Central Bus Station	10:15 PM	San Diego	Seaport Village	Economy	$135	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/26/2026 7:35:00 PM to Seaport Village, San Diego (USA) arriving at 7/28/2026 10:15:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 53h 40m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	57h 55m	9:30 AM	Indianapolis	Washington / Delaware	4:25 PM	San Diego	Old Town Transit Center	Economy	$129	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/27/2026 9:30:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/29/2026 4:25:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 57h 55m
FlixBus	57h 25m	9:30 AM	Indianapolis	Washington / Delaware	3:55 PM	San Diego	La Jolla Village	Economy	$131	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/27/2026 9:30:00 AM to La Jolla Village, San Diego (USA) arriving at 7/29/2026 3:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 57h 25m
Greyhound US	56h 20m	11:05 AM	Indianapolis	Central Bus Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$132	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/27/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/29/2026 4:25:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 56h 20m
FlixBus	55h 15m	1:30 PM	Indianapolis	Washington / Delaware	5:45 PM	San Diego	Old Town Transit Center	Economy	$133	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/27/2026 1:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/29/2026 5:45:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 55h 15m
Greyhound US	49h 10m	7:35 PM	Indianapolis	Central Bus Station	5:45 PM	San Diego	Old Town Transit Center	Economy	$133	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/27/2026 7:35:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/29/2026 5:45:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 49h 10m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	55h 15m	1:30 PM	Indianapolis	Washington / Delaware	5:45 PM	San Diego	Old Town Transit Center	Economy	$147	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/28/2026 1:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/30/2026 5:45:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 55h 15m
FlixBus	57h 55m	9:30 AM	Indianapolis	Washington / Delaware	4:25 PM	San Diego	Old Town Transit Center	Economy	$148	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/28/2026 9:30:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/30/2026 4:25:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 57h 55m
FlixBus	55h 40m	1:30 PM	Indianapolis	Washington / Delaware	6:10 PM	San Diego	Old Town Transit Center	Economy	$148	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/28/2026 1:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/30/2026 6:10:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 55h 40m
Greyhound US	55h 50m	11:05 AM	Indianapolis	Central Bus Station	3:55 PM	San Diego	La Jolla Village	Economy	$148	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/28/2026 11:05:00 AM to La Jolla Village, San Diego (USA) arriving at 7/30/2026 3:55:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 55h 50m
Greyhound US	53h 40m	7:35 PM	Indianapolis	Central Bus Station	10:15 PM	San Diego	Seaport Village	Economy	$148	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/28/2026 7:35:00 PM to Seaport Village, San Diego (USA) arriving at 7/30/2026 10:15:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 53h 40m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	57h 55m	9:30 AM	Indianapolis	Downtown Transit Center	4:25 PM	San Diego	Old Town Transit Center	Economy	$151	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/29/2026 9:30:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/31/2026 4:25:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 57h 55m
Greyhound US	56h 20m	11:05 AM	Indianapolis	Central Bus Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$153	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/29/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/31/2026 4:25:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 56h 20m
FlixBus	57h 25m	9:30 AM	Indianapolis	Washington / Delaware	3:55 PM	San Diego	La Jolla Village	Economy	$155	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/29/2026 9:30:00 AM to La Jolla Village, San Diego (USA) arriving at 7/31/2026 3:55:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 57h 25m
Greyhound US	55h 50m	11:05 AM	Indianapolis	Central Bus Station	3:55 PM	San Diego	La Jolla Village	Economy	$156	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/29/2026 11:05:00 AM to La Jolla Village, San Diego (USA) arriving at 7/31/2026 3:55:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 55h 50m
FlixBus	59h 50m	9:30 AM	Indianapolis	Downtown Transit Center	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$166	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/29/2026 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 7/31/2026 6:20:00 PM. 50 Economy ticket for $166 per person are available. Travel duration is 59h 50m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	56h 20m	11:05 AM	Indianapolis	Central Bus Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$164	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/30/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/1/2026 4:25:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 56h 20m
FlixBus	57h 55m	9:30 AM	Indianapolis	Downtown Transit Center	4:25 PM	San Diego	Old Town Transit Center	Economy	$165	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/30/2026 9:30:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/1/2026 4:25:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 57h 55m
Greyhound US	58h 15m	11:05 AM	Indianapolis	Central Bus Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$173	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/30/2026 11:05:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 8/1/2026 6:20:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 58h 15m
Greyhound US	56h 5m	5:00 AM	Indianapolis	Central Bus Station	10:05 AM	San Diego	Seaport Village	Economy	$174	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/30/2026 5:00:00 AM to Seaport Village, San Diego (USA) arriving at 8/1/2026 10:05:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 56h 5m
FlixBus	59h 50m	9:30 AM	Indianapolis	Downtown Transit Center	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$176	A Bus from FlixBus goes from Downtown Transit Center, Indianapolis (USA) at 7/30/2026 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 8/1/2026 6:20:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 59h 50m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	58h 40m	9:30 AM	Indianapolis	Washington / Delaware	5:10 PM	San Diego	San Ysidro Transit Center	Economy	$167	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/31/2026 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 8/2/2026 5:10:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 58h 40m
FlixBus	59h 50m	9:30 AM	Indianapolis	Washington / Delaware	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$168	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/31/2026 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 8/2/2026 6:20:00 PM. 50 Economy ticket for $168 per person are available. Travel duration is 59h 50m
Greyhound US	58h 15m	11:05 AM	Indianapolis	Central Bus Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$183	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/31/2026 11:05:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 8/2/2026 6:20:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 58h 15m
FlixBus	63h 55m	11:25 PM	Indianapolis	Washington / Delaware	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$184	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 7/31/2026 11:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 8/3/2026 12:20:00 PM. 50 Economy ticket for $184 per person are available. Travel duration is 63h 55m
Greyhound US	73h 10m	8:10 PM	Indianapolis	Central Bus Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$186	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 7/31/2026 8:10:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 8/3/2026 6:20:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 73h 10m

Best Price Offer: The price for the cheapest bus from Indianapolis to San Diego is $109 on 7/21/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Indianapolis and San Diego

See here how frequent the connections between Indianapolis and San Diego are, during different times and days of the week.

Sunday is the busiest day, with more than 36 daily buses from Indianapolis to San Diego. Friday has instead the fewest connections, with only 8 daily coaches between Indianapolis and San Diego.

The busiest time of the day is the Evening, with 75 buses from Indianapolis to San Diego, while Night sees the fewest connections between Indianapolis and San Diego, with 1 offers.

Facts about the bus from Indianapolis to San Diego

Compare all providers like FlixBus and Greyhound US that travel 23 times every day by bus from Indianapolis to San Diego in one click! Book your bus ticket from Indianapolis to San Diego starting from $109!

Cheapest Bus	$109
Fastest Bus	46h 0m
Earliest Bus	9:30 AM
Latest Bus	11:25 PM
Daily Bus Routes	23 Ø
Distance	1,785.2 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Indianapolis to San Diego

Every day, 23 buses from 2 bus companies leave Indianapolis for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

Sunday 07/26

$132

Monday 07/27

$162

Tuesday 07/28

$147

Wednesday 07/29

$155

Thursday 07/30

$164

Friday 07/31

$167

Saturday 08/01

$170

Sunday 08/02

$156

Monday 08/03

$145

Tuesday 08/04

$141

Wednesday 08/05

$170

Thursday 08/06

$160

Friday 08/07

$162

Saturday 08/08

$159

Sunday 08/09

$164

Monday 08/10

$175

Tuesday 08/11

$154

Wednesday 08/12

$155

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from Indianapolis to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Indianapolis to San Diego, for the next 30 days.

With a price starting from $129, Monday is the cheapest day for a bus from Indianapolis to San Diego. Friday instead is the most expensive day with prices starting from $162.

Morning is the cheapest day time for bus tickets from Indianapolis to San Diego, with $129. Evening is the most expensive time of the day with prices starting from $133.

How to save money travelling from Indianapolis to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Indianapolis to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Indianapolis to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Indianapolis to San Diego are also emptier.

All bus stations and stops in Indianapolis and San Diego

In the map below, you can see where to find all bus stations in Indianapolis and San Diego.

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

Downtown

Service and Comfort on the bus from Indianapolis to San Diego

Want to know which seat classes are available on the buses from Indianapolis to San Diego? Or which bus companies serve the route Indianapolis to San Diego? Below you will find answers to your questions.

FAQs about the Indianapolis to San Diego bus

How much does a Indianapolis San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $109 and takes 54h 55m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Indianapolis to San Diego?

This route is offered by 2 companies with a range of ticket prices between $109 and $219. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Indianapolis to San Diego each day?

Every day, the Indianapolis to San Diego bus route is served by approximately 23 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Indianapolis to San Diego take?

The fastest bus from Indianapolis to San Diego is offered by Greyhound US and takes 46h 0m. Bus tickets for this connection cost $140. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Indianapolis to San Diego?

The earliest bus arriving in San Diego from Indianapolis starts at 9:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Indianapolis to San Diego?

The latest bus trip departing from Indianapolis for San Diego starts at 11:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Indianapolis San Diego route?

When traveling by bus from Indianapolis to San Diego, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Indianapolis and San Diego?

You can check all the direct connections between Indianapolis and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Indianapolis to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Indianapolis San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Indianapolis San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Indianapolis to San Diego on your planned travel date.

Available seat classes which are offered on the bus route Indianapolis to San Diego

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Indianapolis and to San Diego

Here’s an overview of the most popular bus routes to Indianapolis and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!