Bus St. Louis, MO to Santa Ana, CA: Compare prices and save money

Compare all timetables for the bus from St. Louis, MO to Santa Ana, CA

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Santa Ana, CA from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

Tuesday

Wednesday

$170

Thursday

Friday

Saturday

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	49h 20m	8:40 AM	St. Louis, MO	Gateway Station	8:00 AM	Santa Ana, CA	Bus Stop	Economy	$170	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 8:40:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 7/31/2026 8:00:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 49h 20m
Greyhound US	44h 10m	1:20 AM	St. Louis, MO	Gateway Station	7:30 PM	Santa Ana, CA	Bus Stop	Economy	$171	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 1:20:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 7/30/2026 7:30:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 44h 10m
FlixBus	53h 30m	4:00 PM	St. Louis, MO	Gateway Station	7:30 PM	Santa Ana, CA	Bus Stop	Economy	$191	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 4:00:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 7/31/2026 7:30:00 PM. 50 Economy ticket for $191 per person are available. Travel duration is 53h 30m

Test cheapest views

The cheapest bus for the 8/2/2026 costs just $160, from Greyhound US

Facts about the bus from St. Louis, MO to Santa Ana, CA

Compare all providers like Greyhound US and FlixBus that travel 3 times every day by bus from St. Louis, MO to Santa Ana, CA in one click! Book your bus ticket from St. Louis, MO to Santa Ana, CA starting from $160!

Cheapest Bus	$160
Fastest Bus	42h 10m
Earliest Bus	1:20 AM
Latest Bus	4:00 PM
Daily Bus Routes	3 Ø
Distance	1,573.3 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from St. Louis, MO to Santa Ana, CA

Every day, 3 buses from 2 bus companies leave St. Louis, MO for Santa Ana, CA: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

Monday 07/27

Tuesday 07/28

Wednesday 07/29

$170

Thursday 07/30

Friday 07/31

Saturday 08/01

Sunday 08/02

$160

Monday 08/03

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

Friday 08/07

Saturday 08/08

$164

Sunday 08/09

Monday 08/10

Tuesday 08/11

Wednesday 08/12

Thursday 08/13

Friday 08/14

Saturday 08/15

Sunday 08/16

Monday 08/17

$166

Tuesday 08/18

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

How to save money travelling from St. Louis, MO to Santa Ana, CA

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Santa Ana, CA in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Santa Ana, CA, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Santa Ana, CA are also emptier.

All bus stations and stops in St. Louis, MO and Santa Ana, CA

In the map below, you can see where to find all bus stations in St. Louis, MO and Santa Ana, CA.

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Bus Stop

1000 E Santa Ana Blvd 105

Service and Comfort on the bus from St. Louis, MO to Santa Ana, CA

Want to know which seat classes are available on the buses from St. Louis, MO to Santa Ana, CA? Or which bus companies serve the route St. Louis, MO to Santa Ana, CA? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Santa Ana, CA bus

How much does a St. Louis, MO Santa Ana, CA bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $160 and takes 47h 20m to reach Santa Ana, CA. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Santa Ana, CA?

This route is offered by 2 companies with a range of ticket prices between $160 and $191. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santa Ana, CA.

On average, how many connections are available from St. Louis, MO to Santa Ana, CA each day?

Every day, the St. Louis, MO to Santa Ana, CA bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Santa Ana, CA take?

The fastest bus from St. Louis, MO to Santa Ana, CA is offered by Greyhound US and takes 42h 10m. Bus tickets for this connection cost $171. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Santa Ana, CA?

The earliest bus arriving in Santa Ana, CA from St. Louis, MO starts at 1:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Santa Ana, CA?

The latest bus trip departing from St. Louis, MO for Santa Ana, CA starts at 4:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Santa Ana, CA route?

When traveling by bus from St. Louis, MO to Santa Ana, CA, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Santa Ana, CA?

You can check all the direct connections between St. Louis, MO and Santa Ana, CA by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the St. Louis, MO to Santa Ana, CA bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Santa Ana, CA bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Santa Ana, CA bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Santa Ana, CA on your planned travel date.

Available seat classes which are offered on the bus route St. Louis, MO to Santa Ana, CA

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Santa Ana, CA

Here’s an overview of the most popular bus routes to St. Louis, MO and to Santa Ana, CA. Simply click on the connection of your choice, and you will find all the details about your bus route!