Bus St. Louis, MO to Philadelphia: Compare prices and save money

Compare all timetables for the bus from St. Louis, MO to Philadelphia

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Philadelphia from various bus operators like Greyhound US or FlixBus for the next days.

today

$111

tomorrow

$91

Tuesday

$91

Wednesday

$91

Thursday

$91

Friday

$97

Saturday

$97

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	25h 20m	11:30 PM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$111	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/26/2026 11:30:00 PM to Central Bus Station, Philadelphia (USA) arriving at 7/28/2026 1:50:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 25h 20m
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Central Bus Station	Economy	$117	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/26/2026 8:45:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/27/2026 8:10:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 22h 25m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Central Bus Station	Economy	$124	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/26/2026 1:55:00 PM to Central Bus Station, Philadelphia (USA) arriving at 7/27/2026 1:00:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 5m

Did you know that if you travel from St. Louis, MO to Philadelphia via Pittsburgh, you can save more than $11? You can find the corresponding connections below.
- Greyhound US
  
  22h 25m
  
  0
  
  8:45 AM
  
  St. Louis, MO
  Gateway Station
  
  12:20 AM
  
  Pittsburgh
  Grant Street Transportation Center
  
  0
  
  Economy
  
  $58
  
  A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 8:45:00 AM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 7/28/2026 12:20:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 14h 35m
- Greyhound US
  
  6h 35m
  
  0
  
  1:35 AM
  
  Pittsburgh
  Grant Street Transportation Center
  
  8:10 AM
  
  Philadelphia
  Central Bus Station
  
  0
  
  Economy
  
  $42
  
  A Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/28/2026 1:35:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/28/2026 8:10:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 6h 35m
Travel Time is 0h 40m shorter, and you will save $11

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 2:00:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/28/2026 1:50:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 50m
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 8:45:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/28/2026 8:10:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 25m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 1:55:00 PM to Central Bus Station, Philadelphia (USA) arriving at 7/28/2026 1:00:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 5m
FlixBus	25h 20m	11:30 PM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$98	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 11:30:00 PM to Central Bus Station, Philadelphia (USA) arriving at 7/29/2026 1:50:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 25h 20m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/28/2026 2:00:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/29/2026 1:50:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 50m
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/28/2026 8:45:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/29/2026 8:10:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 25m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/28/2026 1:55:00 PM to Central Bus Station, Philadelphia (USA) arriving at 7/29/2026 1:00:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 5m
FlixBus	25h 20m	11:30 PM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$97	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/28/2026 11:30:00 PM to Central Bus Station, Philadelphia (USA) arriving at 7/30/2026 1:50:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 25h 20m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 2:00:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/30/2026 1:50:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 50m
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 8:45:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/30/2026 8:10:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 25m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Central Bus Station	Economy	$94	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 1:55:00 PM to Central Bus Station, Philadelphia (USA) arriving at 7/30/2026 1:00:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 22h 5m
FlixBus	25h 20m	11:30 PM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$106	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 11:30:00 PM to Central Bus Station, Philadelphia (USA) arriving at 7/31/2026 1:50:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 25h 20m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/30/2026 2:00:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/31/2026 1:50:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 50m
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/30/2026 8:45:00 AM to Central Bus Station, Philadelphia (USA) arriving at 7/31/2026 8:10:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 22h 25m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Central Bus Station	Economy	$94	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/30/2026 1:55:00 PM to Central Bus Station, Philadelphia (USA) arriving at 7/31/2026 1:00:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 22h 5m
FlixBus	25h 20m	11:30 PM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$107	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/30/2026 11:30:00 PM to Central Bus Station, Philadelphia (USA) arriving at 8/1/2026 1:50:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 25h 20m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$97	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/31/2026 2:00:00 AM to Central Bus Station, Philadelphia (USA) arriving at 8/1/2026 1:50:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 22h 50m
FlixBus	25h 20m	11:30 PM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$105	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/31/2026 11:30:00 PM to Central Bus Station, Philadelphia (USA) arriving at 8/2/2026 1:50:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 25h 20m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Central Bus Station	Economy	$110	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/31/2026 1:55:00 PM to Central Bus Station, Philadelphia (USA) arriving at 8/1/2026 1:00:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 22h 5m
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Central Bus Station	Economy	$113	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/31/2026 8:45:00 AM to Central Bus Station, Philadelphia (USA) arriving at 8/1/2026 8:10:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 22h 25m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	2:00 AM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$97	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 8/1/2026 2:00:00 AM to Central Bus Station, Philadelphia (USA) arriving at 8/2/2026 1:50:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 22h 50m
Greyhound US	22h 25m	8:45 AM	St. Louis, MO	Gateway Station	8:10 AM	Philadelphia	Central Bus Station	Economy	$103	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 8/1/2026 8:45:00 AM to Central Bus Station, Philadelphia (USA) arriving at 8/2/2026 8:10:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 22h 25m
FlixBus	25h 20m	11:30 PM	St. Louis, MO	Gateway Station	1:50 AM	Philadelphia	Central Bus Station	Economy	$109	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 8/1/2026 11:30:00 PM to Central Bus Station, Philadelphia (USA) arriving at 8/3/2026 1:50:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 25h 20m
Greyhound US	22h 5m	1:55 PM	St. Louis, MO	Gateway Station	1:00 PM	Philadelphia	Central Bus Station	Economy	$113	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 8/1/2026 1:55:00 PM to Central Bus Station, Philadelphia (USA) arriving at 8/2/2026 1:00:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 22h 5m

Frequency of bus connections between St. Louis, MO and Philadelphia

See here how frequent the connections between St. Louis, MO and Philadelphia are, during different times and days of the week.

Monday is the busiest day, with more than 8 daily buses from St. Louis, MO to Philadelphia. Friday has instead the fewest connections, with only 4 daily coaches between St. Louis, MO and Philadelphia.

The busiest time of the day is the Morning, with 12 buses from St. Louis, MO to Philadelphia, while Night sees the fewest connections between St. Louis, MO and Philadelphia, with 10 offers.

Test cheapest views

The cheapest bus for the 7/28/2026 costs just $91, from Greyhound US

Facts about the bus from St. Louis, MO to Philadelphia

Compare all providers like Greyhound US and FlixBus that travel 6 times every day by bus from St. Louis, MO to Philadelphia in one click! Book your bus ticket from St. Louis, MO to Philadelphia starting from $91!

Cheapest Bus	$91
Fastest Bus	23h 5m
Earliest Bus	8:45 AM
Latest Bus	11:30 PM
Daily Bus Routes	6 Ø
Distance	807.9 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from St. Louis, MO to Philadelphia

Every day, 6 buses from 2 bus companies leave St. Louis, MO for Philadelphia: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

$100

Monday 07/27

$98

Tuesday 07/28

$91

Wednesday 07/29

$91

Thursday 07/30

$91

Friday 07/31

$97

Saturday 08/01

$97

Sunday 08/02

Monday 08/03

$98

Tuesday 08/04

$98

Wednesday 08/05

Thursday 08/06

Friday 08/07

$104

Saturday 08/08

$99

Sunday 08/09

Monday 08/10

$93

Tuesday 08/11

$93

Wednesday 08/12

Thursday 08/13

$96

Friday 08/14

Saturday 08/15

Sunday 08/16

$91

Monday 08/17

Tuesday 08/18

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

The cheapest time to travel from St. Louis, MO to Philadelphia

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Philadelphia, for the next 30 days.

With a price starting from $91, Sunday is the cheapest day for a bus from St. Louis, MO to Philadelphia. Friday instead is the most expensive day with prices starting from $97.

Morning is the cheapest day time for bus tickets from St. Louis, MO to Philadelphia, with $91. Evening is the most expensive time of the day with prices starting from $97.

How to save money travelling from St. Louis, MO to Philadelphia

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Philadelphia in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Philadelphia, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Philadelphia are also emptier.

All bus stations and stops in St. Louis, MO and Philadelphia

In the map below, you can see where to find all bus stations in St. Louis, MO and Philadelphia.

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Central Bus Station

Filbert St 1001

Market St

Spring Garden St Station

Spring Garden St & 2nd St

JFK & Broad

John F Kennedy Blvd 1401

30th Street Station

Market St 2955

Service and Comfort on the bus from St. Louis, MO to Philadelphia

Want to know which seat classes are available on the buses from St. Louis, MO to Philadelphia? Or which bus companies serve the route St. Louis, MO to Philadelphia? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Philadelphia bus

How much does a St. Louis, MO Philadelphia bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $91 and takes 23h 50m to reach Philadelphia. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Philadelphia?

This route is offered by 2 companies with a range of ticket prices between $91 and $128. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Philadelphia.

On average, how many connections are available from St. Louis, MO to Philadelphia each day?

Every day, the St. Louis, MO to Philadelphia bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Philadelphia take?

The fastest bus from St. Louis, MO to Philadelphia is offered by Greyhound US and takes 23h 5m. Bus tickets for this connection cost $128. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Philadelphia?

The earliest bus arriving in Philadelphia from St. Louis, MO starts at 8:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Philadelphia?

The latest bus trip departing from St. Louis, MO for Philadelphia starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Philadelphia route?

When traveling by bus from St. Louis, MO to Philadelphia, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Philadelphia?

You can check all the direct connections between St. Louis, MO and Philadelphia by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the St. Louis, MO to Philadelphia bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Philadelphia bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Philadelphia bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Philadelphia on your planned travel date.

Available seat classes which are offered on the bus route St. Louis, MO to Philadelphia

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Philadelphia

Here’s an overview of the most popular bus routes to St. Louis, MO and to Philadelphia. Simply click on the connection of your choice, and you will find all the details about your bus route!