Bus Houston to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Houston to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Houston to St. Louis, MO from various bus operators like Greyhound US, FlixBus or Valley Transit for the next days.

today

$128

tomorrow

$129

Monday

$113

Tuesday

Wednesday

$130

Thursday

$111

Friday

$114

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	27h 50m	6:55 PM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station		Economy	$128	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/25/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/26/2026 10:45:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 27h 50m
	FlixBus	27h 10m	7:35 PM	Houston	Downtown Houston	10:45 PM	St. Louis, MO	Gateway Station		Economy	$145	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/25/2026 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/26/2026 10:45:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 27h 10m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	27h 10m	7:35 PM	Houston	Downtown Houston	10:45 PM	St. Louis, MO	Gateway Station	Economy	$129	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/26/2026 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/27/2026 10:45:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 27h 10m
Greyhound US	23h 10m	1:45 PM	Houston	Harrisburg Blvd Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$130	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/26/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/27/2026 12:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 23h 10m
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$131	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/26/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/26/2026 10:45:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 20h 55m
FlixBus	23h 40m	1:15 PM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$132	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/26/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/27/2026 12:55:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 23h 40m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$133	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 7/26/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/27/2026 12:55:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 30h 20m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$113	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/27/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/27/2026 10:45:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 55m
Greyhound US	22h 55m	8:15 AM	Houston	Harrisburg Blvd Station	7:10 AM	St. Louis, MO	Gateway Station	Economy	$113	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/27/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2026 7:10:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 22h 55m
FlixBus	27h 10m	7:35 PM	Houston	Downtown Houston	10:45 PM	St. Louis, MO	Gateway Station	Economy	$117	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/27/2026 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2026 10:45:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 27h 10m
FlixBus	21h 10m	10:00 AM	Houston	Downtown Houston	7:10 AM	St. Louis, MO	Gateway Station	Economy	$121	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/27/2026 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2026 7:10:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 21h 10m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$127	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 7/27/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2026 12:55:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 30h 20m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 10m	1:45 PM	Houston	Harrisburg Blvd Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$130	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/29/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2026 12:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 23h 10m
FlixBus	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$130	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 7/29/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2026 12:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 30h 20m
Greyhound US	27h 50m	6:55 PM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$131	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/29/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2026 10:45:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 27h 50m
FlixBus	25h 45m	11:10 AM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$131	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/29/2026 11:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2026 12:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 25h 45m
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$132	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/29/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/29/2026 10:45:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 20h 55m

Did you know that if you travel from Houston to St. Louis, MO via Dallas, you can save more than $13? You can find the corresponding connections below.
- FlixBus
  
  30h 10m
  
  0
  
  6:45 AM
  
  Houston
  Downtown Houston
  
  11:10 AM
  
  Dallas
  Downtown
  
  0
  
  Economy
  
  $27
  
  A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/30/2026 6:45:00 AM to Downtown, Dallas (USA) arriving at 7/30/2026 11:10:00 AM. 50 Economy ticket for $27 per person are available. Travel duration is 4h 25m
- Greyhound US
  
  17h 5m
  
  0
  
  7:50 PM
  
  Dallas
  Harry Hines @ Webb Chapel Ext - S - MB
  
  12:55 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $90
  
  A Bus from Greyhound US goes from Harry Hines @ Webb Chapel Ext - S - MB, Dallas (USA) at 7/30/2026 7:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 12:55:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 17h 5m
Travel time is 9h 15m longer, but you will save $13

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 10m	1:45 PM	Houston	Harrisburg Blvd Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$111	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/30/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 12:55:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 23h 10m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$113	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 7/30/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 30h 20m
FlixBus	25h 45m	11:10 AM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$113	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/30/2026 11:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 25h 45m
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$118	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/30/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2026 10:45:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 55m
FlixBus	21h 10m	10:00 AM	Houston	Downtown Houston	7:10 AM	St. Louis, MO	Gateway Station	Economy	$130	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/30/2026 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 7:10:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 21h 10m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	25h 0m	10:00 PM	Houston	Harrisburg Blvd Station	11:00 PM	St. Louis, MO	Gateway Station	Economy	$114	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/31/2026 10:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2026 11:00:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 25h 0m
Greyhound US	22h 55m	8:15 AM	Houston	Harrisburg Blvd Station	7:10 AM	St. Louis, MO	Gateway Station	Economy	$121	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 7/31/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2026 7:10:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 22h 55m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$127	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 7/31/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2026 12:55:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 30h 20m
FlixBus	23h 40m	1:15 PM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$127	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/31/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2026 12:55:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 23h 40m
FlixBus	21h 10m	10:00 AM	Houston	Downtown Houston	7:10 AM	St. Louis, MO	Gateway Station	Economy	$128	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 7/31/2026 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2026 7:10:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 21h 10m

Best Price Offer: The price for the cheapest bus from Houston to St. Louis, MO is $101 on 8/7/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Houston and St. Louis, MO

See here how frequent the connections between Houston and St. Louis, MO are, during different times and days of the week.

Sunday is the busiest day, with more than 15 daily buses from Houston to St. Louis, MO. Saturday has instead the fewest connections, with only 2 daily coaches between Houston and St. Louis, MO.

The busiest time of the day is the Morning, with 23 buses from Houston to St. Louis, MO, while Night sees the fewest connections between Houston and St. Louis, MO, with 8 offers.

Facts about the bus from Houston to St. Louis, MO

Compare all providers like Greyhound US, FlixBus and Valley Transit that travel 10 times every day by bus from Houston to St. Louis, MO in one click! Book your bus ticket from Houston to St. Louis, MO starting from $101!

Cheapest Bus	$101
Fastest Bus	20h 55m
Earliest Bus	6:55 PM
Latest Bus	10:00 PM
Daily Bus Routes	10 Ø
Distance	680.5 miles
Bus Companies	Greyhound US, FlixBus and Valley Transit

Cheapest bus connections from Houston to St. Louis, MO

Every day, 10 buses from 3 bus companies leave Houston for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

$128

Sunday 07/26

$133

Monday 07/27

$114

Tuesday 07/28

$128

Wednesday 07/29

$130

Thursday 07/30

$115

Friday 07/31

$114

Saturday 08/01

$115

Sunday 08/02

$116

Monday 08/03

Tuesday 08/04

$115

Wednesday 08/05

$120

Thursday 08/06

$116

Friday 08/07

$101

Saturday 08/08

$115

Sunday 08/09

$117

Monday 08/10

$125

Tuesday 08/11

$109

Wednesday 08/12

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from Houston to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Houston to St. Louis, MO, for the next 30 days.

With a price starting from $101, Friday is the cheapest day for a bus from Houston to St. Louis, MO. Wednesday instead is the most expensive day with prices starting from $120.

Night is the cheapest day time for bus tickets from Houston to St. Louis, MO, with $101. Evening is the most expensive time of the day with prices starting from $114.

How to save money travelling from Houston to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Houston to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Houston to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Houston to St. Louis, MO are also emptier.

All bus stations and stops in Houston and St. Louis, MO

In the map below, you can see where to find all bus stations in Houston and St. Louis, MO.

Downtown Houston

Gray St 605

Harrisburg Blvd Station

Harrisburg Blvd 7000

Main Street

Main St 2121

Chase Bank

Milam Street 212

Uptown/Upper Kirby

Southwest Fwy 2525

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Houston to St. Louis, MO

Want to know which seat classes are available on the buses from Houston to St. Louis, MO? Or which bus companies serve the route Houston to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Houston to St. Louis, MO bus

How much does a Houston St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $101 and takes 23h 10m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Houston to St. Louis, MO?

This route is offered by 3 companies with a range of ticket prices between $101 and $145. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Houston to St. Louis, MO each day?

Every day, the Houston to St. Louis, MO bus route is served by approximately 10 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Houston to St. Louis, MO take?

The fastest bus from Houston to St. Louis, MO is offered by Greyhound US and takes 20h 55m. Bus tickets for this connection cost $131. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Houston to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Houston starts at 6:55 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Houston to St. Louis, MO?

The latest bus trip departing from Houston for St. Louis, MO starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Houston St. Louis, MO route?

When traveling by bus from Houston to St. Louis, MO, passengers can travel with Greyhound US, FlixBus and Valley Transit. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Houston and St. Louis, MO?

You can check all the direct connections between Houston and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US, FlixBus and Valley Transit.

What can I take with me on the Houston to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Houston St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Houston St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Houston to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route Houston to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Houston and to St. Louis, MO

Here’s an overview of the most popular bus routes to Houston and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!