Bus Knoxville, TN to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Knoxville, TN to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to St. Louis, MO from various bus operators like Greyhound US for the next days.

today

$116

tomorrow

$122

Tuesday

$124

Wednesday

Thursday

Friday

Saturday

$120

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	20h 45m	8:00 PM	Knoxville, TN	Greyhound Bus Station	3:45 PM	St. Louis, MO	Gateway Station		Economy	$116	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/26/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/27/2026 3:45:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 20h 45m
	Greyhound US	22h 0m	6:10 PM	Knoxville, TN	Greyhound Bus Station	3:10 PM	St. Louis, MO	Gateway Station		Economy	$138	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/26/2026 6:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/27/2026 3:10:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 22h 0m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	22h 0m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	3:10 PM	St. Louis, MO	Gateway Station		Economy	$122	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/27/2026 6:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2026 3:10:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 22h 0m
	Greyhound US	20h 45m	8:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	3:45 PM	St. Louis, MO	Gateway Station		Economy	$138	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/27/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2026 3:45:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 20h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 0m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	3:10 PM	St. Louis, MO	Gateway Station	Economy	$124	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/28/2026 6:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/29/2026 3:10:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 0m
Greyhound US	21h 5m	7:40 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	3:45 PM	St. Louis, MO	Gateway Station	Economy	$125	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 7/28/2026 7:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/29/2026 3:45:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 21h 5m
Greyhound US	20h 45m	8:00 PM	Knoxville, TN	Greyhound Bus Station	3:45 PM	St. Louis, MO	Gateway Station	Economy	$139	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/28/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/29/2026 3:45:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 20h 45m

Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $49? You can find the corresponding connections below.
- Greyhound US
  
  16h 10m
  
  0
  
  6:10 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  7:55 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $36
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/30/2026 6:10:00 PM to 5th Ave South Station, Nashville (USA) arriving at 7/30/2026 7:55:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 2h 45m
- FlixBus
  
  5h 55m
  
  0
  
  3:25 AM
  
  Nashville
  5th Ave South Station
  
  9:20 AM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $39
  
  A Bus from FlixBus goes from 5th Ave South Station, Nashville (USA) at 7/31/2026 3:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 9:20:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 5h 55m
Travel Time is 3h 35m shorter, and you will save $49

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	22h 0m	6:10 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	3:10 PM	St. Louis, MO	Gateway Station		Economy	$120	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 8/1/2026 6:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/2/2026 3:10:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 22h 0m
	Greyhound US	20h 45m	8:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	3:45 PM	St. Louis, MO	Gateway Station		Economy	$121	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 8/1/2026 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/2/2026 3:45:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 20h 45m

Did you know that if you travel from Knoxville, TN to St. Louis, MO via Nashville, you can save more than $45? You can find the corresponding connections below.
- Greyhound US
  
  16h 10m
  
  0
  
  6:10 PM
  
  Knoxville, TN
  Greyhound Bus Station
  
  7:55 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $36
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 7/30/2026 6:10:00 PM to 5th Ave South Station, Nashville (USA) arriving at 7/30/2026 7:55:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 2h 45m
- FlixBus
  
  5h 55m
  
  0
  
  3:25 AM
  
  Nashville
  5th Ave South Station
  
  9:20 AM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $39
  
  A Bus from FlixBus goes from 5th Ave South Station, Nashville (USA) at 7/31/2026 3:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/31/2026 9:20:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 5h 55m
Travel Time is 3h 35m shorter, and you will save $45

Best Price Offer: The price for the cheapest bus from Knoxville, TN to St. Louis, MO is $100 on 8/16/2026. Flexible travelers save on ticket prices.

Facts about the bus from Knoxville, TN to St. Louis, MO

Compare all providers like Greyhound US that travel 3 times every day by bus from Knoxville, TN to St. Louis, MO in one click! Book your bus ticket from Knoxville, TN to St. Louis, MO starting from $100!

Cheapest Bus	$100
Fastest Bus	19h 45m
Earliest Bus	6:10 PM
Latest Bus	8:00 PM
Daily Bus Routes	3 Ø
Distance	391.5 miles
Bus Companies	Greyhound US

Cheapest bus connections from Knoxville, TN to St. Louis, MO

Every day, 3 buses from 1 bus companies leave Knoxville, TN for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

$116

Monday 07/27

$126

Tuesday 07/28

$124

Wednesday 07/29

$135

Thursday 07/30

Friday 07/31

Saturday 08/01

$120

Sunday 08/02

Monday 08/03

$132

Tuesday 08/04

$169

Wednesday 08/05

Thursday 08/06

Friday 08/07

$108

Saturday 08/08

$115

Sunday 08/09

$119

Monday 08/10

Tuesday 08/11

$112

Wednesday 08/12

Thursday 08/13

Friday 08/14

Saturday 08/15

Sunday 08/16

$100

Monday 08/17

Tuesday 08/18

$111

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

How to save money travelling from Knoxville, TN to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to St. Louis, MO are also emptier.

All bus stations and stops in Knoxville, TN and St. Louis, MO

In the map below, you can see where to find all bus stations in Knoxville, TN and St. Louis, MO.

Kingston Pike

Kingston Pike 6927

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Transit Center

E Church Ave 301

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Knoxville, TN to St. Louis, MO

Want to know which seat classes are available on the buses from Knoxville, TN to St. Louis, MO? Or which bus companies serve the route Knoxville, TN to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Knoxville, TN to St. Louis, MO bus

How much does a Knoxville, TN St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $100 and takes 19h 45m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $100 and $142. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Knoxville, TN to St. Louis, MO each day?

Every day, the Knoxville, TN to St. Louis, MO bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to St. Louis, MO take?

The fastest bus from Knoxville, TN to St. Louis, MO is offered by Greyhound US and takes 19h 45m. Bus tickets for this connection cost $116. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Knoxville, TN starts at 6:10 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to St. Louis, MO?

The latest bus trip departing from Knoxville, TN for St. Louis, MO starts at 8:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN St. Louis, MO route?

When traveling by bus from Knoxville, TN to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and St. Louis, MO?

You can check all the direct connections between Knoxville, TN and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route Knoxville, TN to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to St. Louis, MO

Here’s an overview of the most popular bus routes to Knoxville, TN and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!