Bus Santa Ana, CA to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Santa Ana, CA to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Santa Ana, CA to St. Louis, MO from various bus operators like Greyhound US for the next days.

today

$152

tomorrow

$140

Tuesday

$157

Wednesday

Thursday

$170

Friday

$158

Saturday

$158

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	47h 10m	9:35 PM	Santa Ana, CA	Bus Stop	10:45 PM	St. Louis, MO	Gateway Station		Economy	$152	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/26/2026 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2026 10:45:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 47h 10m
	Greyhound US	47h 20m	11:35 AM	Santa Ana, CA	Bus Stop	12:55 PM	St. Louis, MO	Gateway Station		Economy	$174	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/26/2026 11:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2026 12:55:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 47h 20m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	47h 10m	9:35 PM	Santa Ana, CA	Bus Stop	10:45 PM	St. Louis, MO	Gateway Station	Economy	$140	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/27/2026 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/29/2026 10:45:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 47h 10m
Greyhound US	47h 20m	11:35 AM	Santa Ana, CA	Bus Stop	12:55 PM	St. Louis, MO	Gateway Station	Economy	$148	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/27/2026 11:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/29/2026 12:55:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 47h 20m
Greyhound US	45h 30m	7:40 AM	Santa Ana, CA	Bus Stop	7:10 AM	St. Louis, MO	Gateway Station	Economy	$165	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/27/2026 7:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/29/2026 7:10:00 AM. 50 Economy ticket for $165 per person are available. Travel duration is 45h 30m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	47h 10m	9:35 PM	Santa Ana, CA	Bus Stop	10:45 PM	St. Louis, MO	Gateway Station	Economy	$157	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/28/2026 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2026 10:45:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 47h 10m
Greyhound US	47h 20m	11:35 AM	Santa Ana, CA	Bus Stop	12:55 PM	St. Louis, MO	Gateway Station	Economy	$158	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/28/2026 11:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2026 12:55:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 47h 20m
Greyhound US	45h 30m	7:40 AM	Santa Ana, CA	Bus Stop	7:10 AM	St. Louis, MO	Gateway Station	Economy	$170	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/28/2026 7:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/30/2026 7:10:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 45h 30m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	47h 20m	11:35 AM	Santa Ana, CA	Bus Stop	12:55 PM	St. Louis, MO	Gateway Station	Economy	$170	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/30/2026 11:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2026 12:55:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 47h 20m
Greyhound US	45h 30m	7:40 AM	Santa Ana, CA	Bus Stop	7:10 AM	St. Louis, MO	Gateway Station	Economy	$197	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/30/2026 7:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2026 7:10:00 AM. 50 Economy ticket for $197 per person are available. Travel duration is 45h 30m
Greyhound US	47h 10m	9:35 PM	Santa Ana, CA	Bus Stop	10:45 PM	St. Louis, MO	Gateway Station	Economy	$198	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/30/2026 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/1/2026 10:45:00 PM. 50 Economy ticket for $198 per person are available. Travel duration is 47h 10m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	47h 20m	11:35 AM	Santa Ana, CA	Bus Stop	12:55 PM	St. Louis, MO	Gateway Station	Economy	$158	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/31/2026 11:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/2/2026 12:55:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 47h 20m
Greyhound US	47h 10m	9:35 PM	Santa Ana, CA	Bus Stop	10:45 PM	St. Louis, MO	Gateway Station	Economy	$174	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/31/2026 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/2/2026 10:45:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 47h 10m
Greyhound US	45h 30m	7:40 AM	Santa Ana, CA	Bus Stop	7:10 AM	St. Louis, MO	Gateway Station	Economy	$209	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 7/31/2026 7:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/2/2026 7:10:00 AM. 50 Economy ticket for $209 per person are available. Travel duration is 45h 30m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	47h 10m	9:35 PM	Santa Ana, CA	Bus Stop	10:45 PM	St. Louis, MO	Gateway Station	Economy	$158	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 8/1/2026 9:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 8/3/2026 10:45:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 47h 10m
Greyhound US	47h 20m	11:35 AM	Santa Ana, CA	Bus Stop	12:55 PM	St. Louis, MO	Gateway Station	Economy	$164	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 8/1/2026 11:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/3/2026 12:55:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 47h 20m
Greyhound US	45h 30m	7:40 AM	Santa Ana, CA	Bus Stop	7:10 AM	St. Louis, MO	Gateway Station	Economy	$180	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 8/1/2026 7:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 8/3/2026 7:10:00 AM. 50 Economy ticket for $180 per person are available. Travel duration is 45h 30m

Best Price Offer: The price for the cheapest bus from Santa Ana, CA to St. Louis, MO is $129 on 8/16/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Santa Ana, CA and St. Louis, MO

See here how frequent the connections between Santa Ana, CA and St. Louis, MO are, during different times and days of the week.

Monday is the busiest day, with more than 3 daily buses from Santa Ana, CA to St. Louis, MO. Sunday has instead the fewest connections, with only 2 daily coaches between Santa Ana, CA and St. Louis, MO.

The busiest time of the day is the Morning, with 11 buses from Santa Ana, CA to St. Louis, MO, while Evening sees the fewest connections between Santa Ana, CA and St. Louis, MO, with 6 offers.

Facts about the bus from Santa Ana, CA to St. Louis, MO

Compare all providers like Greyhound US that travel 2 times every day by bus from Santa Ana, CA to St. Louis, MO in one click! Book your bus ticket from Santa Ana, CA to St. Louis, MO starting from $129!

Cheapest Bus	$129
Fastest Bus	47h 30m
Earliest Bus	11:35 AM
Latest Bus	9:35 PM
Daily Bus Routes	2 Ø
Distance	1,573.3 miles
Bus Companies	Greyhound US

Cheapest bus connections from Santa Ana, CA to St. Louis, MO

Every day, 2 buses from 1 bus companies leave Santa Ana, CA for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

$147

Monday 07/27

$140

Tuesday 07/28

$157

Wednesday 07/29

$162

Thursday 07/30

$170

Friday 07/31

$162

Saturday 08/01

$158

Sunday 08/02

$149

Monday 08/03

$152

Tuesday 08/04

$162

Wednesday 08/05

$186

Thursday 08/06

$167

Friday 08/07

$162

Saturday 08/08

$163

Sunday 08/09

$161

Monday 08/10

$172

Tuesday 08/11

$182

Wednesday 08/12

$159

Thursday 08/13

Friday 08/14

Saturday 08/15

Sunday 08/16

$129

Monday 08/17

Tuesday 08/18

$144

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

The cheapest time to travel from Santa Ana, CA to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Santa Ana, CA to St. Louis, MO, for the next 30 days.

With a price starting from $129, Sunday is the cheapest day for a bus from Santa Ana, CA to St. Louis, MO. Thursday instead is the most expensive day with prices starting from $167.

Evening is the cheapest day time for bus tickets from Santa Ana, CA to St. Louis, MO, with $140. Morning is the most expensive time of the day with prices starting from $148.

How to save money travelling from Santa Ana, CA to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santa Ana, CA to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santa Ana, CA to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santa Ana, CA to St. Louis, MO are also emptier.

All bus stations and stops in Santa Ana, CA and St. Louis, MO

In the map below, you can see where to find all bus stations in Santa Ana, CA and St. Louis, MO.

Bus Stop

1000 E Santa Ana Blvd 105

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Santa Ana, CA to St. Louis, MO

Want to know which seat classes are available on the buses from Santa Ana, CA to St. Louis, MO? Or which bus companies serve the route Santa Ana, CA to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Santa Ana, CA to St. Louis, MO bus

How much does a Santa Ana, CA St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $129 and takes 49h 10m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Santa Ana, CA to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $129 and $209. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Santa Ana, CA to St. Louis, MO each day?

Every day, the Santa Ana, CA to St. Louis, MO bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santa Ana, CA to St. Louis, MO take?

The fastest bus from Santa Ana, CA to St. Louis, MO is offered by Greyhound US and takes 47h 30m. Bus tickets for this connection cost $165. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santa Ana, CA to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Santa Ana, CA starts at 11:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santa Ana, CA to St. Louis, MO?

The latest bus trip departing from Santa Ana, CA for St. Louis, MO starts at 9:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santa Ana, CA St. Louis, MO route?

When traveling by bus from Santa Ana, CA to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santa Ana, CA and St. Louis, MO?

You can check all the direct connections between Santa Ana, CA and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Santa Ana, CA to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santa Ana, CA St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santa Ana, CA St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santa Ana, CA to St. Louis, MO on your planned travel date.

Available seat classes which are offered on the bus route Santa Ana, CA to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santa Ana, CA and to St. Louis, MO

Here’s an overview of the most popular bus routes to Santa Ana, CA and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!