Bus St. Louis, MO to Chicago: Compare prices and save money

Compare all timetables for the bus from St. Louis, MO to Chicago

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today

$40

tomorrow

Monday

$38

Tuesday

$37

Wednesday

$44

Thursday

$40

Friday

$47

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	6h 5m	10:00 AM	St. Louis, MO	Gateway Station	4:05 PM	Chicago	Downtown Bus Station	Economy	$40	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/25/2026 10:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/25/2026 4:05:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 6h 5m
FlixBus	6h 5m	4:00 PM	St. Louis, MO	Gateway Station	10:05 PM	Chicago	Downtown Bus Station	Economy	$40	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/25/2026 4:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/25/2026 10:05:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 6h 5m
FlixBus	6h 15m	11:30 PM	St. Louis, MO	Gateway Station	5:45 AM	Chicago	Downtown Bus Station	Economy	$40	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/25/2026 11:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/26/2026 5:45:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 6h 15m
FlixBus	5h 50m	11:30 PM	St. Louis, MO	Gateway Station	5:20 AM	Chicago	95th Red Line Station	Economy	$41	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/25/2026 11:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/26/2026 5:20:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 5h 50m
FlixBus	8h 25m	10:00 AM	St. Louis, MO	Gateway Station	6:25 PM	Chicago	95th Red Line Station	Economy	$48	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/25/2026 10:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/25/2026 6:25:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 8h 25m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 50m	11:30 PM	St. Louis, MO	Gateway Station	5:20 AM	Chicago	95th Red Line Station	Economy	$38	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 11:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/28/2026 5:20:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 5h 50m
FlixBus	6h 5m	10:00 AM	St. Louis, MO	Gateway Station	4:05 PM	Chicago	Downtown Bus Station	Economy	$40	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 10:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/27/2026 4:05:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 6h 5m
FlixBus	6h 5m	4:00 PM	St. Louis, MO	Gateway Station	10:05 PM	Chicago	Downtown Bus Station	Economy	$40	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 4:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/27/2026 10:05:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 6h 5m
Greyhound US	11h 45m	2:00 AM	St. Louis, MO	Gateway Station	1:45 PM	Chicago	Union Station	Economy	$47	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 2:00:00 AM to Union Station, Chicago (USA) arriving at 7/27/2026 1:45:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 11h 45m
Greyhound US	11h 15m	2:00 AM	St. Louis, MO	Gateway Station	1:15 PM	Chicago	95th Red Line Station	Economy	$60	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/27/2026 2:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/27/2026 1:15:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 11h 15m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 50m	11:30 PM	St. Louis, MO	Gateway Station	5:20 AM	Chicago	95th Red Line Station	Economy	$37	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/28/2026 11:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/29/2026 5:20:00 AM. 50 Economy ticket for $37 per person are available. Travel duration is 5h 50m
FlixBus	8h 35m	10:00 AM	St. Louis, MO	Gateway Station	6:35 PM	Chicago	95th Red Line Station	Economy	$39	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/28/2026 10:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/28/2026 6:35:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 8h 35m
FlixBus	7h 35m	4:00 PM	St. Louis, MO	Gateway Station	11:35 PM	Chicago	95th Red Line Station	Economy	$39	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/28/2026 4:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/28/2026 11:35:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 7h 35m
Greyhound US	11h 15m	2:00 AM	St. Louis, MO	Gateway Station	1:15 PM	Chicago	95th Red Line Station	Economy	$52	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/28/2026 2:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/28/2026 1:15:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 11h 15m
Greyhound US	11h 45m	2:00 AM	St. Louis, MO	Gateway Station	1:45 PM	Chicago	Canal & Van Buren	Economy	$54	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/28/2026 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 7/28/2026 1:45:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 11h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 50m	11:30 PM	St. Louis, MO	Gateway Station	5:20 AM	Chicago	95th Red Line Station	Economy	$44	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 11:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2026 5:20:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 50m
FlixBus	6h 5m	10:00 AM	St. Louis, MO	Gateway Station	4:05 PM	Chicago	Downtown Bus Station	Economy	$44	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 10:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/29/2026 4:05:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 6h 5m
FlixBus	6h 5m	4:00 PM	St. Louis, MO	Gateway Station	10:05 PM	Chicago	Downtown Bus Station	Economy	$44	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 4:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/29/2026 10:05:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 6h 5m
Greyhound US	11h 15m	2:00 AM	St. Louis, MO	Gateway Station	1:15 PM	Chicago	95th Red Line Station	Economy	$58	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 2:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/29/2026 1:15:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 11h 15m
Greyhound US	11h 45m	2:00 AM	St. Louis, MO	Gateway Station	1:45 PM	Chicago	Union Station	Economy	$61	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 2:00:00 AM to Union Station, Chicago (USA) arriving at 7/29/2026 1:45:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 11h 45m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 40m	10:00 AM	St. Louis, MO	Gateway Station	7:40 PM	Chicago	95th Red Line Station	Economy	$40	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/30/2026 10:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2026 7:40:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 9h 40m
FlixBus	7h 35m	4:00 PM	St. Louis, MO	Gateway Station	11:35 PM	Chicago	95th Red Line Station	Economy	$40	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/30/2026 4:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2026 11:35:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 7h 35m
FlixBus	6h 5m	10:00 AM	St. Louis, MO	Gateway Station	4:05 PM	Chicago	Downtown Bus Station	Economy	$41	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/30/2026 10:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/30/2026 4:05:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 6h 5m
Greyhound US	11h 15m	2:00 AM	St. Louis, MO	Gateway Station	1:15 PM	Chicago	95th Red Line Station	Economy	$48	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/30/2026 2:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/30/2026 1:15:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 11h 15m
Greyhound US	11h 45m	2:00 AM	St. Louis, MO	Gateway Station	1:45 PM	Chicago	Canal & Van Buren	Economy	$50	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/30/2026 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 7/30/2026 1:45:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 11h 45m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 50m	11:30 PM	St. Louis, MO	Gateway Station	5:20 AM	Chicago	95th Red Line Station	Economy	$47	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/31/2026 11:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 8/1/2026 5:20:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 5h 50m
FlixBus	6h 5m	10:00 AM	St. Louis, MO	Gateway Station	4:05 PM	Chicago	Downtown Bus Station	Economy	$48	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/31/2026 10:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 7/31/2026 4:05:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 6h 5m
FlixBus	6h 5m	4:00 PM	St. Louis, MO	Gateway Station	10:05 PM	Chicago	Downtown Bus Station	Economy	$48	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 7/31/2026 4:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 7/31/2026 10:05:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 6h 5m
Greyhound US	11h 15m	2:00 AM	St. Louis, MO	Gateway Station	1:15 PM	Chicago	95th Red Line Station	Economy	$81	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/31/2026 2:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 7/31/2026 1:15:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 11h 15m
Greyhound US	11h 45m	2:00 AM	St. Louis, MO	Gateway Station	1:45 PM	Chicago	Union Station	Economy	$83	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/31/2026 2:00:00 AM to Union Station, Chicago (USA) arriving at 7/31/2026 1:45:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 11h 45m

Frequency of bus connections between St. Louis, MO and Chicago

See here how frequent the connections between St. Louis, MO and Chicago are, during different times and days of the week.

Monday is the busiest day, with more than 17 daily buses from St. Louis, MO to Chicago. Saturday has instead the fewest connections, with only 6 daily coaches between St. Louis, MO and Chicago.

The busiest time of the day is the Morning, with 18 buses from St. Louis, MO to Chicago, while Night sees the fewest connections between St. Louis, MO and Chicago, with 17 offers.

Test cheapest views

The cheapest bus for the 8/5/2026 costs just $36, from FlixBus

Facts about the bus from St. Louis, MO to Chicago

Compare all providers like FlixBus and Greyhound US that travel 11 times every day by bus from St. Louis, MO to Chicago in one click! Book your bus ticket from St. Louis, MO to Chicago starting from $36!

Cheapest Bus	$36
Fastest Bus	5h 50m
Earliest Bus	10:00 AM
Latest Bus	11:30 PM
Daily Bus Routes	11 Ø
Distance	262.3 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from St. Louis, MO to Chicago

Every day, 11 buses from 2 bus companies leave St. Louis, MO for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

$41

Sunday 07/26

$41

Monday 07/27

$44

Tuesday 07/28

$41

Wednesday 07/29

$44

Thursday 07/30

$40

Friday 07/31

$48

Saturday 08/01

$44

Sunday 08/02

$44

Monday 08/03

$40

Tuesday 08/04

$39

Wednesday 08/05

$36

Thursday 08/06

$37

Friday 08/07

Saturday 08/08

$41

Sunday 08/09

$40

Monday 08/10

$37

Tuesday 08/11

$38

Wednesday 08/12

$40

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from St. Louis, MO to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to Chicago, for the next 30 days.

With a price starting from $36, Wednesday is the cheapest day for a bus from St. Louis, MO to Chicago. Friday instead is the most expensive day with prices starting from $47.

Night is the cheapest day time for bus tickets from St. Louis, MO to Chicago, with $36. Morning is the most expensive time of the day with prices starting from $39.

How to save money travelling from St. Louis, MO to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to Chicago are also emptier.

Beloved bus companies from St. Louis, MO to Chicago

These are the most booked bus companies between St. Louis, MO to Chicago from our users.

FlixBus from St. Louis, MO to Chicago

Here you will find the key facts about the FlixBus bus route St. Louis, MO to Chicago:

Cheapest Price	$37
Fastest Bus	5h 50m
Earliest Bus	10:00 AM
Last Bus	11:30 PM
Daily Connections	9 Ø
Found on	7/10/2026

All bus stations and stops in St. Louis, MO and Chicago

In the map below, you can see where to find all bus stations in St. Louis, MO and Chicago.

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from St. Louis, MO to Chicago

Want to know which seat classes are available on the buses from St. Louis, MO to Chicago? Or which bus companies serve the route St. Louis, MO to Chicago? Below you will find answers to your questions.

FAQs about the St. Louis, MO to Chicago bus

How much does a St. Louis, MO Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $36 and takes 5h 50m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to Chicago?

This route is offered by 2 companies with a range of ticket prices between $36 and $83. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from St. Louis, MO to Chicago each day?

Every day, the St. Louis, MO to Chicago bus route is served by approximately 11 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to Chicago take?

The fastest bus from St. Louis, MO to Chicago is offered by FlixBus and takes 5h 50m. Bus tickets for this connection cost $41. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to Chicago?

The earliest bus arriving in Chicago from St. Louis, MO starts at 10:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to Chicago?

The latest bus trip departing from St. Louis, MO for Chicago starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO Chicago route?

When traveling by bus from St. Louis, MO to Chicago, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and Chicago?

You can check all the direct connections between St. Louis, MO and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the St. Louis, MO to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to Chicago on your planned travel date.

Available seat classes which are offered on the bus route St. Louis, MO to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to Chicago

Here’s an overview of the most popular bus routes to St. Louis, MO and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!