Bus Orlando, FL to Florence, SC: Compare prices and save money

Compare all timetables for the bus from Orlando, FL to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Orlando, FL to Florence, SC from various bus operators like FlixBus for the next days.

today

$88

tomorrow

Monday

$80

Tuesday

$88

Wednesday

Thursday

Friday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	8h 40m	4:45 AM	Orlando, FL	Bus Station	1:25 PM	Florence, SC	Bus Station		Economy	$88	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/25/2026 4:45:00 AM to Bus Station, Florence, SC (USA) arriving at 7/25/2026 1:25:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 8h 40m
	FlixBus	11h 30m	6:00 AM	Orlando, FL	Bus Station	5:30 PM	Florence, SC	Bus Station		Economy	$90	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/25/2026 6:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/25/2026 5:30:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 11h 30m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	8h 40m	4:45 AM	Orlando, FL	Bus Station	1:25 PM	Florence, SC	Bus Station		Economy	$80	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/27/2026 4:45:00 AM to Bus Station, Florence, SC (USA) arriving at 7/27/2026 1:25:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 8h 40m
	FlixBus	11h 30m	6:00 AM	Orlando, FL	Bus Station	5:30 PM	Florence, SC	Bus Station		Economy	$81	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/27/2026 6:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/27/2026 5:30:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 11h 30m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 30m	6:00 AM	Orlando, FL	Bus Station	5:30 PM	Florence, SC	Bus Station	Economy	$88	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/28/2026 6:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/28/2026 5:30:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 11h 30m
FlixBus	16h 50m	10:55 PM	Orlando, FL	Bus Station	3:45 PM	Florence, SC	Bus Station	Economy	$88	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/28/2026 10:55:00 PM to Bus Station, Florence, SC (USA) arriving at 7/29/2026 3:45:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 16h 50m
FlixBus	16h 25m	9:05 PM	Orlando, FL	Bus Station	1:30 PM	Florence, SC	Bus Station	Economy	$94	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/28/2026 9:05:00 PM to Bus Station, Florence, SC (USA) arriving at 7/29/2026 1:30:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 16h 25m
FlixBus	18h 40m	2:30 PM	Orlando, FL	Bus Station	9:10 AM	Florence, SC	Bus Station	Economy	$104	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/28/2026 2:30:00 PM to Bus Station, Florence, SC (USA) arriving at 7/29/2026 9:10:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 18h 40m

Did you know that if you travel from Orlando, FL to Florence, SC via Jacksonville, FL, you can save more than $26? You can find the corresponding connections below.
- FlixBus
  
  8h 40m
  
  0
  
  4:45 AM
  
  Orlando, FL
  Bus Station
  
  7:45 AM
  
  Jacksonville, FL
  Downtown Bus Stop
  
  0
  
  Economy
  
  $19
  
  A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 7/30/2026 4:45:00 AM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 7/30/2026 7:45:00 AM. 50 Economy ticket for $19 per person are available. Travel duration is 3h 0m
- FlixBus
  
  5h 10m
  
  0
  
  8:15 AM
  
  Jacksonville, FL
  Downtown Bus Stop
  
  1:25 PM
  
  Florence, SC
  Bus Station
  
  0
  
  Economy
  
  $43
  
  A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 7/30/2026 8:15:00 AM to Bus Station, Florence, SC (USA) arriving at 7/30/2026 1:25:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 10m
Travel Time is 2h 50m shorter, and you will save $26

Frequency of bus connections between Orlando, FL and Florence, SC

See here how frequent the connections between Orlando, FL and Florence, SC are, during different times and days of the week.

Tuesday is the busiest day, with more than 4 daily buses from Orlando, FL to Florence, SC. Monday has instead the fewest connections, with only 2 daily coaches between Orlando, FL and Florence, SC.

The busiest time of the day is the Morning, with 3 buses from Orlando, FL to Florence, SC, while Afternoon sees the fewest connections between Orlando, FL and Florence, SC, with 1 offers.

Test cheapest views

The cheapest bus for the 7/20/2026 costs just $60, from FlixBus

Facts about the bus from Orlando, FL to Florence, SC

Compare all providers like FlixBus that travel 2 times every day by bus from Orlando, FL to Florence, SC in one click! Book your bus ticket from Orlando, FL to Florence, SC starting from $60!

Cheapest Bus	$60
Fastest Bus	8h 40m
Earliest Bus	4:45 AM
Latest Bus	10:55 PM
Daily Bus Routes	2 Ø
Distance	402.2 miles
Bus Companies	FlixBus

Cheapest bus connections from Orlando, FL to Florence, SC

Every day, 2 buses from 1 bus companies leave Orlando, FL for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

$64

Sunday 07/26

Monday 07/27

Tuesday 07/28

$88

Wednesday 07/29

$62

Thursday 07/30

Friday 07/31

$68

Saturday 08/01

Sunday 08/02

$70

Monday 08/03

$86

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

Friday 08/07

$68

Saturday 08/08

$70

Sunday 08/09

$70

Monday 08/10

Tuesday 08/11

$86

Wednesday 08/12

$62

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from Orlando, FL to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Orlando, FL to Florence, SC, for the next 30 days.

With a price starting from $64, Saturday is the cheapest day for a bus from Orlando, FL to Florence, SC. Tuesday instead is the most expensive day with prices starting from $86.

Night is the cheapest day time for bus tickets from Orlando, FL to Florence, SC, with $62. Afternoon is the most expensive time of the day with prices starting from $103.

How to save money travelling from Orlando, FL to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Orlando, FL to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Orlando, FL to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Orlando, FL to Florence, SC are also emptier.

All bus stations and stops in Orlando, FL and Florence, SC

In the map below, you can see where to find all bus stations in Orlando, FL and Florence, SC.

Bus Station

N John Young Pkwy 555

Florida Mall

Florida Mall Avenue 1602

RedCoach Station

Belle Isle

Universal Studio Orlando Resort

Universal Blvd 5800

UCF (University of Central Florida)

Libra Drive 3820

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Orlando, FL to Florence, SC

Want to know which seat classes are available on the buses from Orlando, FL to Florence, SC? Or which bus companies serve the route Orlando, FL to Florence, SC? Below you will find answers to your questions.

FAQs about the Orlando, FL to Florence, SC bus

How much does a Orlando, FL Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $60 and takes 8h 40m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Orlando, FL to Florence, SC?

This route is offered by 1 companies with a range of ticket prices between $60 and $104. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Orlando, FL to Florence, SC each day?

Every day, the Orlando, FL to Florence, SC bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Orlando, FL to Florence, SC take?

The fastest bus from Orlando, FL to Florence, SC is offered by FlixBus and takes 8h 40m. Bus tickets for this connection cost $88. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Orlando, FL to Florence, SC?

The earliest bus arriving in Florence, SC from Orlando, FL starts at 4:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Orlando, FL to Florence, SC?

The latest bus trip departing from Orlando, FL for Florence, SC starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Orlando, FL Florence, SC route?

When traveling by bus from Orlando, FL to Florence, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Orlando, FL and Florence, SC?

You can check all the direct connections between Orlando, FL and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Orlando, FL to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Orlando, FL Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Orlando, FL Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Orlando, FL to Florence, SC on your planned travel date.

Available seat classes which are offered on the bus route Orlando, FL to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Orlando, FL and to Florence, SC

Here’s an overview of the most popular bus routes to Orlando, FL and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!