Bus Jacksonville, FL to Florence, SC: Compare prices and save money

Compare all timetables for the bus from Jacksonville, FL to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Jacksonville, FL to Florence, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

$48

tomorrow

Sunday

Monday

$44

Tuesday

Wednesday

$44

Thursday

$43

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 10m	8:15 AM	Jacksonville, FL	Amtrak Train Station	1:25 PM	Florence, SC	Bus Station	Economy	$48	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/24/2026 8:15:00 AM to Bus Station, Florence, SC (USA) arriving at 7/24/2026 1:25:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 5h 10m
FlixBus	5h 35m	6:30 PM	Jacksonville, FL	Amtrak Train Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$48	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/24/2026 6:30:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/25/2026 12:05:00 AM. 50 Economy ticket for $48 per person are available. Travel duration is 5h 35m
Greyhound US	7h 30m	10:00 AM	Jacksonville, FL	Amtrak Train Station	5:30 PM	Florence, SC	Bus Station	Economy	$51	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/24/2026 10:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/24/2026 5:30:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 7h 30m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 10m	8:15 AM	Jacksonville, FL	Amtrak Train Station	1:25 PM	Florence, SC	Bus Station	Economy	$44	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/27/2026 8:15:00 AM to Bus Station, Florence, SC (USA) arriving at 7/27/2026 1:25:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 10m
FlixBus	5h 35m	6:30 PM	Jacksonville, FL	Amtrak Train Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$45	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/27/2026 6:30:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/28/2026 12:05:00 AM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 35m
Greyhound US	7h 30m	10:00 AM	Jacksonville, FL	Amtrak Train Station	5:30 PM	Florence, SC	Bus Station	Economy	$47	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/27/2026 10:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/27/2026 5:30:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 30m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 10m	8:15 AM	Jacksonville, FL	Amtrak Train Station	1:25 PM	Florence, SC	Bus Station	Economy	$44	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/29/2026 8:15:00 AM to Bus Station, Florence, SC (USA) arriving at 7/29/2026 1:25:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 10m
FlixBus	5h 35m	6:30 PM	Jacksonville, FL	Amtrak Train Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$44	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/29/2026 6:30:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/30/2026 12:05:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 35m
Greyhound US	7h 30m	10:00 AM	Jacksonville, FL	Amtrak Train Station	5:30 PM	Florence, SC	Bus Station	Economy	$47	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 7/29/2026 10:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/29/2026 5:30:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 30m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	5h 10m	8:15 AM	Jacksonville, FL	Downtown Bus Stop	1:25 PM	Florence, SC	Bus Station		Economy	$43	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 7/30/2026 8:15:00 AM to Bus Station, Florence, SC (USA) arriving at 7/30/2026 1:25:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 10m
	Greyhound US	7h 30m	10:00 AM	Jacksonville, FL	Downtown Bus Stop	5:30 PM	Florence, SC	Bus Station		Economy	$50	A Bus from Greyhound US goes from Downtown Bus Stop, Jacksonville, FL (USA) at 7/30/2026 10:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/30/2026 5:30:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 7h 30m

Frequency of bus connections between Jacksonville, FL and Florence, SC

See here how frequent the connections between Jacksonville, FL and Florence, SC are, during different times and days of the week.

Monday is the busiest day, with more than 3 daily buses from Jacksonville, FL to Florence, SC. Thursday has instead the fewest connections, with only 2 daily coaches between Jacksonville, FL and Florence, SC.

The busiest time of the day is the Morning, with 8 buses from Jacksonville, FL to Florence, SC, while Evening sees the fewest connections between Jacksonville, FL and Florence, SC, with 3 offers.

Test cheapest views

The cheapest bus for the 7/22/2026 costs just $41, from FlixBus

Facts about the bus from Jacksonville, FL to Florence, SC

Compare all providers like FlixBus and Greyhound US that travel 2 times every day by bus from Jacksonville, FL to Florence, SC in one click! Book your bus ticket from Jacksonville, FL to Florence, SC starting from $41!

Cheapest Bus	$41
Fastest Bus	5h 10m
Earliest Bus	8:15 AM
Latest Bus	10:00 AM
Daily Bus Routes	2 Ø
Distance	289.6 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Jacksonville, FL to Florence, SC

Every day, 2 buses from 2 bus companies leave Jacksonville, FL for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/24/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

$48

Saturday 07/25

Sunday 07/26

Monday 07/27

$44

Tuesday 07/28

Wednesday 07/29

$44

Thursday 07/30

$43

Friday 07/31

Saturday 08/01

$54

Sunday 08/02

Monday 08/03

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

Friday 08/07

$52

Saturday 08/08

$47

Sunday 08/09

Monday 08/10

Tuesday 08/11

Wednesday 08/12

$51

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from Jacksonville, FL to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Jacksonville, FL to Florence, SC, for the next 30 days.

With a price starting from $43, Thursday is the cheapest day for a bus from Jacksonville, FL to Florence, SC. Friday instead is the most expensive day with prices starting from $48.

Morning is the cheapest day time for bus tickets from Jacksonville, FL to Florence, SC, with $43. Evening is the most expensive time of the day with prices starting from $44.

How to save money travelling from Jacksonville, FL to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Jacksonville, FL to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Jacksonville, FL to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Jacksonville, FL to Florence, SC are also emptier.

All bus stations and stops in Jacksonville, FL and Florence, SC

In the map below, you can see where to find all bus stations in Jacksonville, FL and Florence, SC.

Downtown Bus Stop

West Forsyth Street 1111

Beaver St. & Ocean St. Bus Stop

Central Bus Station

Old St. Augustine Rd

Old St. Augustine Rd 10584-13

Friendship Fountain

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Jacksonville, FL to Florence, SC

Want to know which seat classes are available on the buses from Jacksonville, FL to Florence, SC? Or which bus companies serve the route Jacksonville, FL to Florence, SC? Below you will find answers to your questions.

FAQs about the Jacksonville, FL to Florence, SC bus

How much does a Jacksonville, FL Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $41 and takes 5h 10m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Jacksonville, FL to Florence, SC?

This route is offered by 2 companies with a range of ticket prices between $41 and $51. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Jacksonville, FL to Florence, SC each day?

Every day, the Jacksonville, FL to Florence, SC bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Jacksonville, FL to Florence, SC take?

The fastest bus from Jacksonville, FL to Florence, SC is offered by FlixBus and takes 5h 10m. Bus tickets for this connection cost $48. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Jacksonville, FL to Florence, SC?

The earliest bus arriving in Florence, SC from Jacksonville, FL starts at 8:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Jacksonville, FL to Florence, SC?

The latest bus trip departing from Jacksonville, FL for Florence, SC starts at 10:00 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Jacksonville, FL Florence, SC route?

When traveling by bus from Jacksonville, FL to Florence, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Jacksonville, FL and Florence, SC?

You can check all the direct connections between Jacksonville, FL and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Jacksonville, FL to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Jacksonville, FL Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Jacksonville, FL Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Jacksonville, FL to Florence, SC on your planned travel date.

Available seat classes which are offered on the bus route Jacksonville, FL to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Jacksonville, FL and to Florence, SC

Here’s an overview of the most popular bus routes to Jacksonville, FL and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!