Which bus from Greenville, SC to Indianapolis is the cheapest?

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Compare all timetables for the bus from Greenville, SC to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Indianapolis from various bus operators like FlixBus or Greyhound US for the next days.

today
tomorrow
$92
Tuesday
$86
Wednesday
Thursday
$79
Friday
$91
Saturday
$92

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 50m 8:20 PM Greenville, SC Woodruff Rd 12:10 PM Indianapolis Central Bus Station  Economy $92
FlixBus 15h 35m 1:20 PM Greenville, SC Woodruff Rd 4:55 AM Indianapolis Central Bus Station  Economy $93
Greyhound US 18h 45m 2:45 PM Greenville, SC Woodruff Rd 9:30 AM Indianapolis Central Bus Station  Economy $93
FlixBus 20h 35m 9:35 PM Greenville, SC Woodruff Rd 6:10 PM Indianapolis Central Bus Station  Economy $94
FlixBus 24h 10m 9:35 PM Greenville, SC Woodruff Rd 9:45 PM Indianapolis Downtown Transit Center  Economy $96
  • Did you know that if you travel from Greenville, SC to Indianapolis via Atlanta, GA, you can save more than $11? You can find the corresponding connections below.
    • Greyhound US
      18h 45m
      0
      2:45 PM
      Greenville, SC
      Woodruff Rd
      5:35 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $23
      • Waiting Time 4h 5m
    • Greyhound US
      11h 50m
      0
      9:40 PM
      Atlanta, GA
      Garnett Transit Station
      9:30 AM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $58
    Travel time is 3h 10m longer, but you will save $11

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 20h 35m 9:35 PM Greenville, SC Woodruff Rd 6:10 PM Indianapolis Central Bus Station  Economy $86
Greyhound US 18h 45m 2:45 PM Greenville, SC Woodruff Rd 9:30 AM Indianapolis Central Bus Station  Economy $86
Greyhound US 15h 50m 8:20 PM Greenville, SC Woodruff Rd 12:10 PM Indianapolis Central Bus Station  Economy $87
FlixBus 24h 10m 9:35 PM Greenville, SC Woodruff Rd 9:45 PM Indianapolis Downtown Transit Center  Economy $88
FlixBus 15h 35m 1:20 PM Greenville, SC Woodruff Rd 4:55 AM Indianapolis Central Bus Station  Economy $90
  • Did you know that if you travel from Greenville, SC to Indianapolis via Atlanta, GA, you can save more than $15? You can find the corresponding connections below.
    • Greyhound US
      20h 25m
      0
      8:20 PM
      Greenville, SC
      Woodruff Rd
      11:30 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $21
      • Waiting Time 5h 35m
    • Greyhound US
      11h 40m
      0
      5:05 AM
      Atlanta, GA
      Garnett Transit Station
      4:45 PM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $50
    Travel time is 4h 50m longer, but you will save $15

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 50m 8:20 PM Greenville, SC Woodruff Rd 12:10 PM Indianapolis Central Bus Station  Economy $79
Greyhound US 18h 45m 2:45 PM Greenville, SC Woodruff Rd 9:30 AM Indianapolis Central Bus Station  Economy $80
Greyhound US 17h 15m 2:45 PM Greenville, SC Woodruff Rd 8:00 AM Indianapolis Downtown Transit Center  Economy $81
FlixBus 20h 35m 9:35 PM Greenville, SC Woodruff Rd 6:10 PM Indianapolis Central Bus Station  Economy $83
FlixBus 15h 35m 1:20 PM Greenville, SC Woodruff Rd 4:55 AM Indianapolis Central Bus Station  Economy $87
  • Did you know that if you travel from Greenville, SC to Indianapolis via Atlanta, GA, you can save more than $8? You can find the corresponding connections below.
    • Greyhound US
      20h 25m
      0
      8:20 PM
      Greenville, SC
      Woodruff Rd
      11:30 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $21
      • Waiting Time 5h 35m
    • Greyhound US
      11h 40m
      0
      5:05 AM
      Atlanta, GA
      Garnett Transit Station
      4:45 PM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $50
    Travel time is 4h 50m longer, but you will save $8

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 15h 50m 8:20 PM Greenville, SC Woodruff Rd 12:10 PM Indianapolis Central Bus Station  Economy $91
FlixBus 15h 35m 1:20 PM Greenville, SC Woodruff Rd 4:55 AM Indianapolis Central Bus Station  Economy $92
Greyhound US 18h 45m 2:45 PM Greenville, SC Woodruff Rd 9:30 AM Indianapolis Central Bus Station  Economy $92
Greyhound US 17h 15m 2:45 PM Greenville, SC Woodruff Rd 8:00 AM Indianapolis Washington / Delaware  Economy $92
FlixBus 24h 10m 9:35 PM Greenville, SC Woodruff Rd 9:45 PM Indianapolis Washington / Delaware  Economy $93
  • Did you know that if you travel from Greenville, SC to Indianapolis via Atlanta, GA, you can save more than $20? You can find the corresponding connections below.
    • Greyhound US
      20h 25m
      0
      8:20 PM
      Greenville, SC
      Woodruff Rd
      11:30 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $21
      • Waiting Time 5h 35m
    • Greyhound US
      11h 40m
      0
      5:05 AM
      Atlanta, GA
      Garnett Transit Station
      4:45 PM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $50
    Travel time is 4h 50m longer, but you will save $20

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 15h 35m 1:20 PM Greenville, SC Woodruff Rd 4:55 AM Indianapolis Central Bus Station  Economy $92
Greyhound US 18h 45m 2:45 PM Greenville, SC Woodruff Rd 9:30 AM Indianapolis Central Bus Station  Economy $92
Greyhound US 15h 50m 8:20 PM Greenville, SC Woodruff Rd 12:10 PM Indianapolis Central Bus Station  Economy $93
Greyhound US 17h 15m 2:45 PM Greenville, SC Woodruff Rd 8:00 AM Indianapolis Washington / Delaware  Economy $93
FlixBus 24h 10m 9:35 PM Greenville, SC Woodruff Rd 9:45 PM Indianapolis Washington / Delaware  Economy $94
  • Did you know that if you travel from Greenville, SC to Indianapolis via Atlanta, GA, you can save more than $21? You can find the corresponding connections below.
    • Greyhound US
      20h 25m
      0
      8:20 PM
      Greenville, SC
      Woodruff Rd
      11:30 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $21
      • Waiting Time 5h 35m
    • Greyhound US
      11h 40m
      0
      5:05 AM
      Atlanta, GA
      Garnett Transit Station
      4:45 PM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $50
    Travel time is 4h 50m longer, but you will save $21

Best Price Offer: The price for the cheapest bus from Greenville, SC to Indianapolis is $78 on 8/7/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Greenville, SC and Indianapolis

See here how frequent the connections between Greenville, SC and Indianapolis are, during different times and days of the week.
Tuesday is the busiest day, with more than 10 daily buses from Greenville, SC to Indianapolis. Monday has instead the fewest connections, with only 6 daily coaches between Greenville, SC and Indianapolis.
The busiest time of the day is the Evening, with 19 buses from Greenville, SC to Indianapolis, while Afternoon sees the fewest connections between Greenville, SC and Indianapolis, with 16 offers.

Facts about the bus from Greenville, SC to Indianapolis

Compare all providers like FlixBus and Greyhound US that travel 7 times every day by bus from Greenville, SC to Indianapolis in one click! Book your bus ticket from Greenville, SC to Indianapolis starting from $78!

Cheapest Bus $78
Fastest Bus 15h 35m
Earliest Bus 1:20 PM
Latest Bus 9:35 PM
Daily Bus Routes 7 Ø
Distance 397.5 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Indianapolis

Every day, 7 buses from 2 bus companies leave Greenville, SC for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 07/26
Monday 07/27
$92
Tuesday 07/28
$86
Wednesday 07/29
$91
Thursday 07/30
$79
Friday 07/31
$91
Saturday 08/01
$92
Sunday 08/02
$95
Monday 08/03
Tuesday 08/04
$87
Wednesday 08/05
Thursday 08/06
$84
Friday 08/07
$78
Saturday 08/08
Sunday 08/09
Monday 08/10
$81
Tuesday 08/11
$86
Wednesday 08/12
$92
Thursday 08/13
Friday 08/14
Saturday 08/15
Sunday 08/16
Monday 08/17
Tuesday 08/18
Wednesday 08/19
Thursday 08/20
Friday 08/21
Saturday 08/22

The cheapest time to travel from Greenville, SC to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Indianapolis, for the next 30 days.
With a price starting from $78, Friday is the cheapest day for a bus from Greenville, SC to Indianapolis. Saturday instead is the most expensive day with prices starting from $92.
Evening is the cheapest day time for bus tickets from Greenville, SC to Indianapolis, with $79. Afternoon is the most expensive time of the day with prices starting from $80.

How to save money travelling from Greenville, SC to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Indianapolis are also emptier.

All bus stations and stops in Greenville, SC and Indianapolis

In the map below, you can see where to find all bus stations in Greenville, SC and Indianapolis.

Service and Comfort on the bus from Greenville, SC to Indianapolis

Want to know which seat classes are available on the buses from Greenville, SC to Indianapolis? Or which bus companies serve the route Greenville, SC to Indianapolis? Below you will find answers to your questions.

FAQs about the Greenville, SC to Indianapolis bus

How much does a Greenville, SC Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $78 and takes 15h 50m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $78 and $100. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Greenville, SC to Indianapolis each day?

Every day, the Greenville, SC to Indianapolis bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Indianapolis take?

The fastest bus from Greenville, SC to Indianapolis is offered by FlixBus and takes 15h 35m. Bus tickets for this connection cost $93. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Indianapolis?

The earliest bus arriving in Indianapolis from Greenville, SC starts at 1:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Indianapolis?

The latest bus trip departing from Greenville, SC for Indianapolis starts at 9:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Indianapolis route?

When traveling by bus from Greenville, SC to Indianapolis, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Indianapolis?

You can check all the direct connections between Greenville, SC and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route Greenville, SC to Indianapolis

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Indianapolis

Here’s an overview of the most popular bus routes to Greenville, SC and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Greenville, SC and to Indianapolis
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