Compare all timetables for the bus from Chicago to Greenville, SC
Here is a selection of the cheapest bus trips from the schedule from Chicago to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 21h 10m | 6:00 PM | Chicago | Downtown Bus Station | 4:10 PM | Greenville, SC | Woodruff Rd | Economy | $86 |
A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 7/29/2026 6:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 4:10:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 21h 10m
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| Greyhound US | 20h 5m | 6:10 AM | Chicago | Downtown Bus Station | 3:15 AM | Greenville, SC | Woodruff Rd | Economy | $94 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 7/29/2026 6:10:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 3:15:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 5m
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| Greyhound US | 20h 15m | 2:45 PM | Chicago | Downtown Bus Station | 12:00 PM | Greenville, SC | Woodruff Rd | Economy | $97 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 7/29/2026 2:45:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 12:00:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 20h 15m
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| Greyhound US | 21h 40m | 10:50 PM | Chicago | Downtown Bus Station | 9:30 PM | Greenville, SC | Woodruff Rd | Economy | $113 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 7/29/2026 10:50:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 7/30/2026 9:30:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 21h 40m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 20h 10m | 1:30 PM | Chicago | 95th Red Line Station | 10:40 AM | Greenville, SC | Woodruff Rd | Economy | $94 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 7/31/2026 1:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2026 10:40:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 10m
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| FlixBus | 20h 40m | 6:30 PM | Chicago | 95th Red Line Station | 4:10 PM | Greenville, SC | Woodruff Rd | Economy | $96 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 7/31/2026 6:30:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2026 4:10:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 20h 40m
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| Greyhound US | 18h 55m | 2:45 PM | Chicago | Downtown Bus Station | 10:40 AM | Greenville, SC | Woodruff Rd | Economy | $100 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 7/31/2026 2:45:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2026 10:40:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 18h 55m
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| FlixBus | 20h 50m | 5:25 AM | Chicago | 95th Red Line Station | 3:15 AM | Greenville, SC | Woodruff Rd | Economy | $101 |
A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 7/31/2026 5:25:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2026 3:15:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 20h 50m
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| Greyhound US | 20h 5m | 9:55 AM | Chicago | Downtown Bus Station | 7:00 AM | Greenville, SC | Woodruff Rd | Economy | $102 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 7/31/2026 9:55:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/1/2026 7:00:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 20h 5m
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Best Price Offer: The price for the cheapest bus from Chicago to Greenville, SC is $81 on 8/8/2026. Flexible travelers save on ticket prices.
Frequency of bus connections between Chicago and Greenville, SC
Friday
is the busiest day, with more than 24 daily buses from Chicago to Greenville, SC. Wednesday has instead the fewest connections, with only 7 daily coaches between Chicago and Greenville, SC.
The busiest time of the day is the Evening, with 13 buses from Chicago to Greenville, SC, while Night sees the fewest connections between Chicago and Greenville, SC, with 4 offers.
Facts about the bus from Chicago to Greenville, SC
Compare all providers like Greyhound US and FlixBus that travel 15 times every day by bus from Chicago to Greenville, SC in one click! Book your bus ticket from Chicago to Greenville, SC starting from $81!
| Cheapest Bus | $81 |
| Fastest Bus | 19h 55m |
| Earliest Bus | 6:10 AM |
| Latest Bus | 11:45 PM |
| Daily Bus Routes | 15 Ø |
| Distance | 562.3 miles |
| Bus Companies | Greyhound US and FlixBus |
Cheapest bus connections from Chicago to Greenville, SC
Every day, 15 buses from 2 bus companies leave Chicago for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
07/19
Monday
07/20
Tuesday
07/21
Wednesday
07/22
Thursday
07/23
Friday
07/24
Saturday
07/25
$101
Sunday
07/26
$90
Monday
07/27
$88
Tuesday
07/28
$101
Wednesday
07/29
$86
Thursday
07/30
$101
Friday
07/31
$94
Saturday
08/01
$101
Sunday
08/02
$93
Monday
08/03
$92
Tuesday
08/04
Wednesday
08/05
$91
Thursday
08/06
Friday
08/07
Saturday
08/08
$81
Sunday
08/09
$97
Monday
08/10
Tuesday
08/11
$94
Wednesday
08/12
$101
Thursday
08/13
Friday
08/14
Saturday
08/15
The cheapest time to travel from Chicago to Greenville, SC
With a price starting from $86, Wednesday is the cheapest day for a bus from Chicago to Greenville, SC. Friday instead is the most expensive day with prices starting from $94.
Night
is the cheapest day time for bus tickets from Chicago to Greenville, SC, with $81. Morning is the most expensive time of the day with prices starting from $94.
How to save money travelling from Chicago to Greenville, SC
Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:
Book the ticket from Chicago to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Greenville, SC are also emptier.All bus stations and stops in Chicago and Greenville, SC
In the map below, you can see where to find all bus stations in Chicago and Greenville, SC.
Service and Comfort on the bus from Chicago to Greenville, SC
Want to know which seat classes are available on the buses from Chicago to Greenville, SC? Or which bus companies serve the route Chicago to Greenville, SC? Below you will find answers to your questions.
FAQs about the Chicago to Greenville, SC bus
How much does a Chicago Greenville, SC bus trip cost?
This depends on, among other things, the day and time of travel. The cheapest trip is available from $81 and takes 22h 10m to reach Greenville, SC. Compare offers to save money!
How much could I save by comparing buses from Chicago to Greenville, SC?
This route is offered by 2 companies with a range of ticket prices between $81 and $123. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.
On average, how many connections are available from Chicago to Greenville, SC each day?
Every day, the Chicago to Greenville, SC bus route is served by approximately 15 connections. With our search, you can compare bus times to find the perfect trip.
How long does a bus journey from Chicago to Greenville, SC take?
The fastest bus from Chicago to Greenville, SC is offered by Greyhound US and takes 19h 55m. Bus tickets for this connection cost $100. In this context, bear in mind that the journey can take longer due to traffic.
What time is the first bus from Chicago to Greenville, SC?
The earliest bus arriving in Greenville, SC from Chicago starts at 6:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.
What time is the last bus from Chicago to Greenville, SC?
The latest bus trip departing from Chicago for Greenville, SC starts at 11:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.
Which bus companies operate the Chicago Greenville, SC route?
When traveling by bus from Chicago to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.
Is there a direct bus between Chicago and Greenville, SC?
You can check all the direct connections between Chicago and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.
What can I take with me on the Chicago to Greenville, SC bus route?
Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.
What equipment is available for the Chicago Greenville, SC bus route?
The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Greenville, SC on your planned travel date.
Available seat classes which are offered on the bus route Chicago to Greenville, SC
Economy
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to Chicago and to Greenville, SC
Here’s an overview of the most popular bus routes to Chicago and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
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- Bus Routes to Greenville, SC
- Bus to Greenville, SC from Baltimore, MD
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- Durham, NC to Greenville, SC bus
- Bus from Fort Lauderdale, FL to Greenville, SC
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- Bus from Phoenix, AZ to Greenville, SC
- Bus Santiago de Queretaro to Greenville, SC
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Popular Airport Shuttles to Chicago and to Greenville, SC
