Bus Columbia, MO to Indianapolis - Compare all Companies

Compare all timetables for the bus from Columbia, MO to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Columbia, MO to Indianapolis from various bus operators like Greyhound US for the next days.

today

tomorrow

Monday

Tuesday

Wednesday

$56

Thursday

Friday

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	9h 50m	8:30 AM	Columbia, MO	Bus Stop	7:20 PM	Indianapolis	Central Bus Station	Economy	$56	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/29/2026 8:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/29/2026 7:20:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 9h 50m
Greyhound US	10h 20m	8:05 PM	Columbia, MO	Bus Stop	7:25 AM	Indianapolis	Central Bus Station	Economy	$56	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/29/2026 8:05:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 7:25:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 10h 20m
Greyhound US	9h 50m	8:35 PM	Columbia, MO	Red Thread	7:25 AM	Indianapolis	Central Bus Station	Economy	$56	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/29/2026 8:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 7/30/2026 7:25:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 9h 50m
Greyhound US	14h 45m	8:05 PM	Columbia, MO	Bus Stop	11:50 AM	Indianapolis	Washington / Delaware	Economy	$56	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 7/29/2026 8:05:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 7/30/2026 11:50:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 14h 45m
Greyhound US	14h 15m	8:35 PM	Columbia, MO	Red Thread	11:50 AM	Indianapolis	Washington / Delaware	Economy	$56	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/29/2026 8:35:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 7/30/2026 11:50:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 14h 15m

Did you know that if you travel from Columbia, MO to Indianapolis via St. Louis, MO, you can save more than $9? You can find the corresponding connections below.
- Greyhound US
  
  9h 50m
  
  0
  
  8:35 PM
  
  Columbia, MO
  Red Thread
  
  10:55 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $19
  
  A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 7/28/2026 8:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/28/2026 10:55:00 PM. 50 Economy ticket for $19 per person are available. Travel duration is 2h 20m
- Greyhound US
  
  4h 25m
  
  0
  
  2:00 AM
  
  St. Louis, MO
  Gateway Station
  
  7:25 AM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $28
  
  A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 7/29/2026 2:00:00 AM to Central Bus Station, Indianapolis (USA) arriving at 7/29/2026 7:25:00 AM. 50 Economy ticket for $28 per person are available. Travel duration is 4h 25m
Travel Time is 1h 0m shorter, and you will save $9

Best Price Offer: The price for the cheapest bus from Columbia, MO to Indianapolis is $46 on 8/4/2026. Flexible travelers save on ticket prices.

Facts about the bus from Columbia, MO to Indianapolis

Compare all providers like Greyhound US that travel 6 times every day by bus from Columbia, MO to Indianapolis in one click! Book your bus ticket from Columbia, MO to Indianapolis starting from $46!

Cheapest Bus	$46
Fastest Bus	8h 40m
Earliest Bus	8:30 AM
Latest Bus	8:35 PM
Daily Bus Routes	6 Ø
Distance	334.5 miles
Bus Companies	Greyhound US

Cheapest bus connections from Columbia, MO to Indianapolis

Every day, 6 buses from 1 bus companies leave Columbia, MO for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

Sunday 07/26

Monday 07/27

Tuesday 07/28

$53

Wednesday 07/29

$52

Thursday 07/30

Friday 07/31

Saturday 08/01

$48

Sunday 08/02

Monday 08/03

Tuesday 08/04

$46

Wednesday 08/05

Thursday 08/06

$51

Friday 08/07

$59

Saturday 08/08

Sunday 08/09

$59

Monday 08/10

$56

Tuesday 08/11

$49

Wednesday 08/12

Thursday 08/13

Friday 08/14

Saturday 08/15

How to save money travelling from Columbia, MO to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Columbia, MO to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Columbia, MO to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Columbia, MO to Indianapolis are also emptier.

All bus stations and stops in Columbia, MO and Indianapolis

In the map below, you can see where to find all bus stations in Columbia, MO and Indianapolis.

Bus Stop

N 10th St 198

Red Thread

Highway 40 W 6401

University

Fellows Pl 1301-1349

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from Columbia, MO to Indianapolis

Want to know which seat classes are available on the buses from Columbia, MO to Indianapolis? Or which bus companies serve the route Columbia, MO to Indianapolis? Below you will find answers to your questions.

FAQs about the Columbia, MO to Indianapolis bus

How much does a Columbia, MO Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $46 and takes 15h 15m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Columbia, MO to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $46 and $65. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Columbia, MO to Indianapolis each day?

Every day, the Columbia, MO to Indianapolis bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Columbia, MO to Indianapolis take?

The fastest bus from Columbia, MO to Indianapolis is offered by Greyhound US and takes 8h 40m. Bus tickets for this connection cost $65. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Columbia, MO to Indianapolis?

The earliest bus arriving in Indianapolis from Columbia, MO starts at 8:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Columbia, MO to Indianapolis?

The latest bus trip departing from Columbia, MO for Indianapolis starts at 8:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Columbia, MO Indianapolis route?

When traveling by bus from Columbia, MO to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Columbia, MO and Indianapolis?

You can check all the direct connections between Columbia, MO and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Columbia, MO to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Columbia, MO Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Columbia, MO Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Columbia, MO to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route Columbia, MO to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Columbia, MO and to Indianapolis

Here’s an overview of the most popular bus routes to Columbia, MO and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!