Bus Brussels to Prague - Compare all Companies

Compare all timetables for the bus from Brussels to Prague

Here is a selection of the cheapest bus trips from the schedule from Brussels to Prague from various bus operators like FlixBus or European Sleeper for the next days.

today

$34

tomorrow

$33

Wednesday

Thursday

$35

Friday

Saturday

$39

Sunday

$48

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 50m	1:20 AM	Brussels	Midi Bus Station	7:10 PM	Prague	Na Knížecí Station	Economy	$34	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/7/2026 1:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 9/7/2026 7:10:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 17h 50m
FlixBus	17h 0m	3:55 PM	Brussels	North Station	8:55 AM	Prague	Na Knížecí Station	Economy	$34	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/7/2026 3:55:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 9/8/2026 8:55:00 AM. 50 Economy ticket for $34 per person are available. Travel duration is 17h 0m
FlixBus	15h 0m	3:55 PM	Brussels	North Station	6:55 AM	Prague	ÚAN Florenc	Economy	$34	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/7/2026 3:55:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 9/8/2026 6:55:00 AM. 50 Economy ticket for $34 per person are available. Travel duration is 15h 0m
European Sleeper	15h 29m	7:22 PM	Brussels	Midi Bus Station	10:51 AM	Prague	Wilsonova Bus Station	Economy	$362	A Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 9/7/2026 7:22:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 9/8/2026 10:51:00 AM. 50 Economy ticket for $362 per person are available. Travel duration is 15h 29m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 50m	1:20 AM	Brussels	Midi Bus Station	7:10 PM	Prague	ÚAN Florenc	Economy	$33	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/8/2026 1:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 9/8/2026 7:10:00 PM. 50 Economy ticket for $33 per person are available. Travel duration is 17h 50m
FlixBus	17h 0m	3:55 PM	Brussels	North Station	8:55 AM	Prague	Na Knížecí Station	Economy	$33	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/8/2026 3:55:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 9/9/2026 8:55:00 AM. 50 Economy ticket for $33 per person are available. Travel duration is 17h 0m
FlixBus	15h 0m	3:55 PM	Brussels	North Station	6:55 AM	Prague	ÚAN Florenc	Economy	$33	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/8/2026 3:55:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 9/9/2026 6:55:00 AM. 50 Economy ticket for $33 per person are available. Travel duration is 15h 0m
FlixBus	15h 55m	10:55 AM	Brussels	North Station	2:50 AM	Prague	Wilsonova Bus Station	Economy	$33	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/8/2026 10:55:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 9/9/2026 2:50:00 AM. 50 Economy ticket for $33 per person are available. Travel duration is 15h 55m
FlixBus	17h 40m	10:30 PM	Brussels	Midi Bus Station	4:10 PM	Prague	Černý Most	Economy	$33	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/8/2026 10:30:00 PM to Černý Most, Prague (Czech Republic) arriving at 9/9/2026 4:10:00 PM. 50 Economy ticket for $33 per person are available. Travel duration is 17h 40m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 25m	4:40 PM	Brussels	Midi Bus Station	10:05 AM	Prague	Na Knížecí Station	Economy	$35	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/10/2026 4:40:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 9/11/2026 10:05:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 17h 25m
FlixBus	15h 55m	10:55 AM	Brussels	North Station	2:50 AM	Prague	Wilsonova Bus Station	Economy	$35	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/10/2026 10:55:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 9/11/2026 2:50:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 15h 55m
FlixBus	18h 35m	10:55 PM	Brussels	North Station	5:30 PM	Prague	Wilsonova Bus Station	Economy	$35	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/10/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 9/11/2026 5:30:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 18h 35m
FlixBus	17h 40m	10:30 PM	Brussels	Midi Bus Station	4:10 PM	Prague	Černý Most	Economy	$35	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/10/2026 10:30:00 PM to Černý Most, Prague (Czech Republic) arriving at 9/11/2026 4:10:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 17h 40m
FlixBus	17h 50m	1:20 AM	Brussels	Midi Bus Station	7:10 PM	Prague	ÚAN Florenc	Economy	$36	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/10/2026 1:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 9/10/2026 7:10:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 17h 50m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 50m	1:20 AM	Brussels	Midi Bus Station	7:10 PM	Prague	ÚAN Florenc	Economy	$39	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/12/2026 1:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 9/12/2026 7:10:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 17h 50m
FlixBus	15h 0m	3:55 PM	Brussels	North Station	6:55 AM	Prague	ÚAN Florenc	Economy	$40	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/12/2026 3:55:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 9/13/2026 6:55:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 15h 0m
FlixBus	15h 10m	9:30 PM	Brussels	North Station	12:40 PM	Prague	ÚAN Florenc	Economy	$40	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/12/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 9/13/2026 12:40:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 15h 10m
FlixBus	15h 55m	10:55 AM	Brussels	North Station	2:50 AM	Prague	Wilsonova Bus Station	Economy	$40	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/12/2026 10:55:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 9/13/2026 2:50:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 15h 55m
FlixBus	18h 35m	10:55 PM	Brussels	North Station	5:30 PM	Prague	Wilsonova Bus Station	Economy	$40	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/12/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 9/13/2026 5:30:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 18h 35m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	18h 35m	10:55 PM	Brussels	North Station	5:30 PM	Prague	Wilsonova Bus Station	Economy	$48	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/13/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 9/14/2026 5:30:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 18h 35m
FlixBus	15h 55m	7:00 AM	Brussels	North Station	10:55 PM	Prague	Na Knížecí Station	Economy	$49	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 9/13/2026 7:00:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 9/13/2026 10:55:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 15h 55m
FlixBus	17h 40m	10:30 PM	Brussels	Midi Bus Station	4:10 PM	Prague	Černý Most	Economy	$50	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/13/2026 10:30:00 PM to Černý Most, Prague (Czech Republic) arriving at 9/14/2026 4:10:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 17h 40m
FlixBus	17h 55m	3:15 AM	Brussels	Midi Bus Station	9:10 PM	Prague	Na Knížecí Station	Economy	$53	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/13/2026 3:15:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 9/13/2026 9:10:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 55m
FlixBus	16h 40m	4:15 PM	Brussels	Midi Bus Station	8:55 AM	Prague	Na Knížecí Station	Economy	$56	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 9/13/2026 4:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 9/14/2026 8:55:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 16h 40m

Best Price Offer: The price for the cheapest bus from Brussels to Prague is $23 on 9/22/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Brussels and Prague

See here how frequent the connections between Brussels and Prague are, during different times and days of the week.

Sunday is the busiest day, with more than 28 daily buses from Brussels to Prague. Thursday has instead the fewest connections, with only 23 daily coaches between Brussels and Prague.

The busiest time of the day is the Evening, with 51 buses from Brussels to Prague, while Night sees the fewest connections between Brussels and Prague, with 19 offers.

Facts about the bus from Brussels to Prague

Compare all providers like FlixBus and European Sleeper that travel 26 times every day by bus from Brussels to Prague in one click! Book your bus ticket from Brussels to Prague starting from $23!

Cheapest Bus	$23
Fastest Bus	12h 50m
Earliest Bus	1:20 AM
Latest Bus	10:55 PM
Daily Bus Routes	26 Ø
Distance	446.6 miles
Bus Companies	FlixBus and European Sleeper

Cheapest bus connections from Brussels to Prague

Every day, 26 buses from 2 bus companies leave Brussels for Prague: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/07/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

Monday 09/07

$52

Tuesday 09/08

$48

Wednesday 09/09

$133

Thursday 09/10

$35

Friday 09/11

$66

Saturday 09/12

$39

Sunday 09/13

$74

Monday 09/14

$32

Tuesday 09/15

Wednesday 09/16

$24

Thursday 09/17

Friday 09/18

$42

Saturday 09/19

Sunday 09/20

Monday 09/21

$28

Tuesday 09/22

$23

Wednesday 09/23

Thursday 09/24

Friday 09/25

$41

Saturday 09/26

Sunday 09/27

Monday 09/28

$35

Tuesday 09/29

Wednesday 09/30

Thursday 10/01

$51

Friday 10/02

Saturday 10/03

The cheapest time to travel from Brussels to Prague

See here on which day and which time of the day you can find the cheapest bus ticket from Brussels to Prague, for the next 30 days.

With a price starting from $23, Tuesday is the cheapest day for a bus from Brussels to Prague. Sunday instead is the most expensive day with prices starting from $48.

Night is the cheapest day time for bus tickets from Brussels to Prague, with $23. Morning is the most expensive time of the day with prices starting from $33.

How to save money travelling from Brussels to Prague

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Brussels to Prague in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Brussels to Prague, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Brussels to Prague are also emptier.

All bus stations and stops in Brussels and Prague

In the map below, you can see where to find all bus stations in Brussels and Prague.

Midi Bus Station

Avenue Fonsny 1

North Station

Rue du Progrès 80

Congrès

Boulevard Pachéco 7

City Tours

Rue du Marché Aux Herbes 82

Delta

PONT DU, Boulevard des Invalides, 1160 BRUXELLES, Belgium

Na Knížecí Station

Za Ženskými domovy / Ostrovského

ÚAN Florenc

Křižíkova 279

Wilsonova Bus Station

Wilsonova 300/8

Roztyly

Tomíčkova 2234

Hradčanská

Milady Horákové 115/107

Service and Comfort on the bus from Brussels to Prague

Want to know which seat classes are available on the buses from Brussels to Prague? Or which bus companies serve the route Brussels to Prague? Below you will find answers to your questions.

FAQs about the Brussels to Prague bus

How much does a Brussels Prague bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $23 and takes 17h 0m to reach Prague. Compare offers to save money!

How much could I save by comparing buses from Brussels to Prague?

This route is offered by 2 companies with a range of ticket prices between $23 and $362. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Prague.

On average, how many connections are available from Brussels to Prague each day?

Every day, the Brussels to Prague bus route is served by approximately 26 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Brussels to Prague take?

The fastest bus from Brussels to Prague is offered by FlixBus and takes 12h 50m. Bus tickets for this connection cost $74. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Brussels to Prague?

The earliest bus arriving in Prague from Brussels starts at 1:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Brussels to Prague?

The latest bus trip departing from Brussels for Prague starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Brussels Prague route?

When traveling by bus from Brussels to Prague, passengers can travel with FlixBus and European Sleeper. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Brussels and Prague?

You can check all the direct connections between Brussels and Prague by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and European Sleeper.

What can I take with me on the Brussels to Prague bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Brussels Prague bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Brussels Prague bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Brussels to Prague on your planned travel date.

Available seat classes which are offered on the bus route Brussels to Prague

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Brussels and to Prague

Here’s an overview of the most popular bus routes to Brussels and to Prague. Simply click on the connection of your choice, and you will find all the details about your bus route!