Bus Rome to Brussels: Compare prices and save money

Compare all timetables for the bus from Rome to Brussels

Here is a selection of the cheapest bus trips from the schedule from Rome to Brussels from various bus operators like FlixBus for the next days.

today

tomorrow

Friday

Saturday

Sunday

$107

Monday

$101

Tuesday

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	22h 30m	10:10 AM	Rome	Tiburtina Bus Station	8:40 AM	Brussels	North Station	Economy	$107	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/26/2026 10:10:00 AM to North Station, Brussels (Belgium) arriving at 7/27/2026 8:40:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 22h 30m
FlixBus	30h 25m	11:35 PM	Rome	Anagnina Bus Station	6:00 AM	Brussels	North Station	Economy	$110	A Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 7/26/2026 11:35:00 PM to North Station, Brussels (Belgium) arriving at 7/28/2026 6:00:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 30h 25m
FlixBus	23h 25m	12:10 PM	Rome	Tiburtina Bus Station	11:35 AM	Brussels	North Station	Economy	$113	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/26/2026 12:10:00 PM to North Station, Brussels (Belgium) arriving at 7/27/2026 11:35:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 23h 25m
FlixBus	29h 10m	8:00 PM	Rome	Tiburtina Bus Station	1:10 AM	Brussels	Midi Bus Station	Economy	$116	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/26/2026 8:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 7/28/2026 1:10:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 29h 10m
FlixBus	28h 15m	9:25 AM	Rome	Tiburtina Bus Station	1:40 PM	Brussels	Midi Bus Station	Economy	$118	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/26/2026 9:25:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 7/27/2026 1:40:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 28h 15m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	22h 30m	10:10 AM	Rome	Tiburtina Bus Station	8:40 AM	Brussels	North Station	Economy	$101	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/27/2026 10:10:00 AM to North Station, Brussels (Belgium) arriving at 7/28/2026 8:40:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 22h 30m
FlixBus	23h 25m	12:10 PM	Rome	Tiburtina Bus Station	11:35 AM	Brussels	North Station	Economy	$101	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/27/2026 12:10:00 PM to North Station, Brussels (Belgium) arriving at 7/28/2026 11:35:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 23h 25m
FlixBus	29h 45m	12:10 PM	Rome	Tiburtina Bus Station	5:55 PM	Brussels	Midi Bus Station	Economy	$107	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/27/2026 12:10:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 7/28/2026 5:55:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 29h 45m
FlixBus	27h 20m	9:25 AM	Rome	Tiburtina Bus Station	12:45 PM	Brussels	Midi Bus Station	Economy	$108	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/27/2026 9:25:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 7/28/2026 12:45:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 27h 20m
FlixBus	30h 25m	9:25 AM	Rome	Tiburtina Bus Station	3:50 PM	Brussels	Midi Bus Station	Economy	$108	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/27/2026 9:25:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 7/28/2026 3:50:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 30h 25m

Frequency of bus connections between Rome and Brussels

See here how frequent the connections between Rome and Brussels are, during different times and days of the week.

Sunday is the busiest day, with more than 20 daily buses from Rome to Brussels. Sunday has instead the fewest connections, with only 20 daily coaches between Rome and Brussels.

The busiest time of the day is the Morning, with 14 buses from Rome to Brussels, while Night sees the fewest connections between Rome and Brussels, with 2 offers.

Test cheapest views

The cheapest bus for the 7/27/2026 costs just $101, from FlixBus

Facts about the bus from Rome to Brussels

Compare all providers like FlixBus that travel 20 times every day by bus from Rome to Brussels in one click! Book your bus ticket from Rome to Brussels starting from $101!

Cheapest Bus	$101
Fastest Bus	22h 30m
Earliest Bus	1:20 AM
Latest Bus	11:35 PM
Daily Bus Routes	20 Ø
Distance	729.4 miles
Bus Companies	FlixBus

Cheapest bus connections from Rome to Brussels

Every day, 20 buses from 1 bus companies leave Rome for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

$102

Sunday 07/26

$107

Monday 07/27

$101

Tuesday 07/28

Wednesday 07/29

Thursday 07/30

Friday 07/31

Saturday 08/01

Sunday 08/02

$119

Monday 08/03

$112

Tuesday 08/04

$113

Wednesday 08/05

Thursday 08/06

Friday 08/07

Saturday 08/08

$150

Sunday 08/09

$161

Monday 08/10

$129

Tuesday 08/11

$121

Wednesday 08/12

Thursday 08/13

Friday 08/14

$163

Saturday 08/15

The cheapest time to travel from Rome to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Rome to Brussels, for the next 30 days.

With a price starting from $101, Monday is the cheapest day for a bus from Rome to Brussels. Sunday instead is the most expensive day with prices starting from $107.

Morning is the cheapest day time for bus tickets from Rome to Brussels, with $101. Evening is the most expensive time of the day with prices starting from $108.

How to save money travelling from Rome to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Rome to Brussels are also emptier.

All bus stations and stops in Rome and Brussels

In the map below, you can see where to find all bus stations in Rome and Brussels.

Anagnina Bus Station

Piazzale della Stazione Anagnina

Termini Bus Station

Piazza dei Cinquecento 64

Tiburtina Bus Station

Largo Guido Mazzoni 4

Vatican City

Via Crescenzio 19

Midi Bus Station

Avenue Fonsny 1

North Station

Rue du Progrès 80

Congrès

Boulevard Pachéco 7

City Tours

Rue du Marché Aux Herbes 82

Delta

PONT DU, Boulevard des Invalides, 1160 BRUXELLES, Belgium

Service and Comfort on the bus from Rome to Brussels

Want to know which seat classes are available on the buses from Rome to Brussels? Or which bus companies serve the route Rome to Brussels? Below you will find answers to your questions.

FAQs about the Rome to Brussels bus

How much does a Rome Brussels bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $101 and takes 22h 30m to reach Brussels. Compare offers to save money!

How much could I save by comparing buses from Rome to Brussels?

This route is offered by 1 companies with a range of ticket prices between $101 and $189. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Brussels.

On average, how many connections are available from Rome to Brussels each day?

Every day, the Rome to Brussels bus route is served by approximately 20 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Rome to Brussels take?

The fastest bus from Rome to Brussels is offered by FlixBus and takes 22h 30m. Bus tickets for this connection cost $107. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Rome to Brussels?

The earliest bus arriving in Brussels from Rome starts at 1:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Rome to Brussels?

The latest bus trip departing from Rome for Brussels starts at 11:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Rome Brussels route?

When traveling by bus from Rome to Brussels, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Rome and Brussels?

You can check all the direct connections between Rome and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Rome to Brussels bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Rome Brussels bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Brussels on your planned travel date.

Available seat classes which are offered on the bus route Rome to Brussels

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Rome and to Brussels

Here’s an overview of the most popular bus routes to Rome and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!