Bus Madrid to Santander - Compare all Companies

Compare all timetables for the bus from Madrid to Santander

Here is a selection of the cheapest bus trips from the schedule from Madrid to Santander from various bus operators like ALSA for the next days.

today

$43

tomorrow

Thursday

$43

Friday

$47

Saturday

Sunday

$48

Monday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 50m	8:00 AM	Madrid	Avenida de América Bus Station	1:50 PM	Santander	Bus Station	Economy	$43	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/8/2026 8:00:00 AM to Bus Station, Santander (Spain) arriving at 9/8/2026 1:50:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 50m
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$43	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/8/2026 10:30:00 AM to Bus Station, Santander (Spain) arriving at 9/8/2026 4:15:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 45m
ALSA	5h 45m	4:30 PM	Madrid	Avenida de Aragon	10:15 PM	Santander	Bus Station	Economy	$46	A Bus from ALSA goes from Avenida de Aragon, Madrid (Spain) at 9/8/2026 4:30:00 PM to Bus Station, Santander (Spain) arriving at 9/8/2026 10:15:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	1:00 PM	Madrid	Avenida de América Bus Station	6:30 PM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/8/2026 1:00:00 PM to Bus Station, Santander (Spain) arriving at 9/8/2026 6:30:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 30m
ALSA	5h 30m	6:30 PM	Madrid	Avenida de América Bus Station	12:00 AM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/8/2026 6:30:00 PM to Bus Station, Santander (Spain) arriving at 9/9/2026 12:00:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 30m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 50m	8:00 AM	Madrid	Avenida de América Bus Station	1:50 PM	Santander	Bus Station	Economy	$43	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/10/2026 8:00:00 AM to Bus Station, Santander (Spain) arriving at 9/10/2026 1:50:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 50m
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$43	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/10/2026 10:30:00 AM to Bus Station, Santander (Spain) arriving at 9/10/2026 4:15:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	1:00 PM	Madrid	Avenida de América Bus Station	6:30 PM	Santander	Bus Station	Economy	$43	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/10/2026 1:00:00 PM to Bus Station, Santander (Spain) arriving at 9/10/2026 6:30:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 30m
ALSA	5h 45m	4:30 PM	Madrid	Avenida de América Bus Station	10:15 PM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/10/2026 4:30:00 PM to Bus Station, Santander (Spain) arriving at 9/10/2026 10:15:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	6:30 PM	Madrid	Avenida de América Bus Station	12:00 AM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/10/2026 6:30:00 PM to Bus Station, Santander (Spain) arriving at 9/11/2026 12:00:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 30m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 50m	8:00 AM	Madrid	Avenida de América Bus Station	1:50 PM	Santander	Bus Station	Economy	$47	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/11/2026 8:00:00 AM to Bus Station, Santander (Spain) arriving at 9/11/2026 1:50:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 5h 50m
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/11/2026 10:30:00 AM to Bus Station, Santander (Spain) arriving at 9/11/2026 4:15:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	1:00 PM	Madrid	Avenida de América Bus Station	6:30 PM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/11/2026 1:00:00 PM to Bus Station, Santander (Spain) arriving at 9/11/2026 6:30:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 30m
ALSA	5h 45m	4:30 PM	Madrid	Avenida de América Bus Station	10:15 PM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/11/2026 4:30:00 PM to Bus Station, Santander (Spain) arriving at 9/11/2026 10:15:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	6:30 PM	Madrid	Avenida de América Bus Station	12:00 AM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/11/2026 6:30:00 PM to Bus Station, Santander (Spain) arriving at 9/12/2026 12:00:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 30m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 50m	8:00 AM	Madrid	Avenida de América Bus Station	1:50 PM	Santander	Bus Station	Economy	$48	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/13/2026 8:00:00 AM to Bus Station, Santander (Spain) arriving at 9/13/2026 1:50:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 5h 50m
ALSA	5h 45m	10:30 AM	Madrid	Avenida de América Bus Station	4:15 PM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/13/2026 10:30:00 AM to Bus Station, Santander (Spain) arriving at 9/13/2026 4:15:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	1:00 PM	Madrid	Avenida de América Bus Station	6:30 PM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/13/2026 1:00:00 PM to Bus Station, Santander (Spain) arriving at 9/13/2026 6:30:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 30m
ALSA	5h 45m	4:30 PM	Madrid	Avenida de América Bus Station	10:15 PM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/13/2026 4:30:00 PM to Bus Station, Santander (Spain) arriving at 9/13/2026 10:15:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	6:30 PM	Madrid	Avenida de América Bus Station	12:00 AM	Santander	Bus Station	Economy	$49	A Bus from ALSA goes from Avenida de América Bus Station, Madrid (Spain) at 9/13/2026 6:30:00 PM to Bus Station, Santander (Spain) arriving at 9/14/2026 12:00:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 30m

Best Price Offer: The price for the cheapest bus from Madrid to Santander is $3 on 9/6/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Madrid and Santander

See here how frequent the connections between Madrid and Santander are, during different times and days of the week.

Tuesday is the busiest day, with more than 18 daily buses from Madrid to Santander. Thursday has instead the fewest connections, with only 7 daily coaches between Madrid and Santander.

The busiest time of the day is the Afternoon, with 24 buses from Madrid to Santander, while Night sees the fewest connections between Madrid and Santander, with 5 offers.

Facts about the bus from Madrid to Santander

Compare all providers like ALSA that travel 13 times every day by bus from Madrid to Santander in one click! Book your bus ticket from Madrid to Santander starting from $3!

Cheapest Bus	$3
Fastest Bus	5h 30m
Earliest Bus	8:00 AM
Latest Bus	6:30 PM
Daily Bus Routes	13 Ø
Distance	210.6 miles
Bus Companies	ALSA

Cheapest bus connections from Madrid to Santander

Every day, 13 buses from 1 bus companies leave Madrid for Santander: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/08/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

Monday 09/07

Tuesday 09/08

Wednesday 09/09

Thursday 09/10

Friday 09/11

$47

Saturday 09/12

Sunday 09/13

Monday 09/14

$59

Tuesday 09/15

Wednesday 09/16

$59

Thursday 09/17

$13

Friday 09/18

Saturday 09/19

$47

Sunday 09/20

Monday 09/21

$55

Tuesday 09/22

Wednesday 09/23

$59

Thursday 09/24

Friday 09/25

Saturday 09/26

Sunday 09/27

$48

Monday 09/28

Tuesday 09/29

Wednesday 09/30

Thursday 10/01

Friday 10/02

Saturday 10/03

The cheapest time to travel from Madrid to Santander

See here on which day and which time of the day you can find the cheapest bus ticket from Madrid to Santander, for the next 30 days.

With a price starting from $3, Sunday is the cheapest day for a bus from Madrid to Santander. Friday instead is the most expensive day with prices starting from $47.

Night is the cheapest day time for bus tickets from Madrid to Santander, with $3. Evening is the most expensive time of the day with prices starting from $49.

How to save money travelling from Madrid to Santander

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Madrid to Santander in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Madrid to Santander, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Madrid to Santander are also emptier.

All bus stations and stops in Madrid and Santander

In the map below, you can see where to find all bus stations in Madrid and Santander.

Avenida de América Bus Station

Avenida de América 13

Bus Stop

Calle de Tiziano 40

Intercambiador de Moncloa

Calle de la Princesa 89n

Plaza de Castilla

Sur Bus Station

Calle de Méndez Álvaro 83

Bus Station

Plaza Las Estaciones

Bus Stop

Astillero

Av. Chiclana 16

Peñacastillo

Calle Camarreal-Ojaiz 65

Sardinero

Calle Real Racing Club

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Madrid to Santander? Compare all modes of transports from Madrid to Santander.

Service and Comfort on the bus from Madrid to Santander

Want to know which seat classes are available on the buses from Madrid to Santander? Or which bus companies serve the route Madrid to Santander? Below you will find answers to your questions.

FAQs about the Madrid to Santander bus

How much does a Madrid Santander bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $3 and takes 5h 50m to reach Santander. Compare offers to save money!

How much could I save by comparing buses from Madrid to Santander?

This route is offered by 1 companies with a range of ticket prices between $3 and $71. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santander.

On average, how many connections are available from Madrid to Santander each day?

Every day, the Madrid to Santander bus route is served by approximately 13 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Madrid to Santander take?

The fastest bus from Madrid to Santander is offered by ALSA and takes 5h 30m. Bus tickets for this connection cost $49. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Madrid to Santander?

The earliest bus arriving in Santander from Madrid starts at 8:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Madrid to Santander?

The latest bus trip departing from Madrid for Santander starts at 6:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Madrid Santander route?

When traveling by bus from Madrid to Santander, passengers can travel with ALSA. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Madrid and Santander?

You can check all the direct connections between Madrid and Santander by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: ALSA.

What can I take with me on the Madrid to Santander bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Madrid Santander bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Madrid Santander bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Madrid to Santander on your planned travel date.

Available seat classes which are offered on the bus route Madrid to Santander

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Madrid and to Santander

Here’s an overview of the most popular bus routes to Madrid and to Santander. Simply click on the connection of your choice, and you will find all the details about your bus route!