Bus Greenville, SC to Port Saint Lucie, FL

Compare all timetables for the bus from Greenville, SC to Port Saint Lucie, FL

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Port Saint Lucie, FL from various bus operators like Greyhound US or FlixBus for the next days.

today

$80

tomorrow

$86

Tuesday

$89

Wednesday

$95

Thursday

$101

Friday

$101

Saturday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	16h 0m	11:15 AM	Greenville, SC	Woodruff Rd	3:15 AM	Port Saint Lucie, FL	SW Gatlin Blvd & SW Brescia St Bus Stop	Economy	$80	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/26/2026 11:15:00 AM to SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) arriving at 7/27/2026 3:15:00 AM. 50 Economy ticket for $80 per person are available. Travel duration is 16h 0m
FlixBus	28h 0m	9:35 PM	Greenville, SC	Woodruff Rd	1:35 AM	Port Saint Lucie, FL	SW Gatlin Blvd & SW Brescia St Bus Stop	Economy	$83	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 7/26/2026 9:35:00 PM to SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) arriving at 7/28/2026 1:35:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 28h 0m
Greyhound US	14h 45m	8:20 PM	Greenville, SC	Woodruff Rd	11:05 AM	Port Saint Lucie, FL	SW Gatlin Blvd & SW Brescia St Bus Stop	Economy	$99	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/26/2026 8:20:00 PM to SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) arriving at 7/27/2026 11:05:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 14h 45m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	16h 0m	11:15 AM	Greenville, SC	Woodruff Rd	3:15 AM	Port Saint Lucie, FL	RaceTrac Gas Station		Economy	$86	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/27/2026 11:15:00 AM to RaceTrac Gas Station, Port Saint Lucie, FL (USA) arriving at 7/28/2026 3:15:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 16h 0m
	Greyhound US	14h 45m	8:20 PM	Greenville, SC	Woodruff Rd	11:05 AM	Port Saint Lucie, FL	RaceTrac Gas Station		Economy	$88	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/27/2026 8:20:00 PM to RaceTrac Gas Station, Port Saint Lucie, FL (USA) arriving at 7/28/2026 11:05:00 AM. 50 Economy ticket for $88 per person are available. Travel duration is 14h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	28h 0m	9:35 PM	Greenville, SC	Woodruff Rd	1:35 AM	Port Saint Lucie, FL	SW Gatlin Blvd & SW Brescia St Bus Stop	Economy	$89	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 7/28/2026 9:35:00 PM to SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) arriving at 7/30/2026 1:35:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 28h 0m
Greyhound US	16h 0m	11:15 AM	Greenville, SC	Woodruff Rd	3:15 AM	Port Saint Lucie, FL	SW Gatlin Blvd & SW Brescia St Bus Stop	Economy	$91	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/28/2026 11:15:00 AM to SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) arriving at 7/29/2026 3:15:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 16h 0m
Greyhound US	14h 45m	8:20 PM	Greenville, SC	Woodruff Rd	11:05 AM	Port Saint Lucie, FL	SW Gatlin Blvd & SW Brescia St Bus Stop	Economy	$118	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/28/2026 8:20:00 PM to SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) arriving at 7/29/2026 11:05:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 14h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	28h 0m	9:35 PM	Greenville, SC	Woodruff Rd	1:35 AM	Port Saint Lucie, FL	RaceTrac Gas Station	Economy	$95	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 7/29/2026 9:35:00 PM to RaceTrac Gas Station, Port Saint Lucie, FL (USA) arriving at 7/31/2026 1:35:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 28h 0m
Greyhound US	20h 5m	7:10 AM	Greenville, SC	Woodruff Rd	3:15 AM	Port Saint Lucie, FL	RaceTrac Gas Station	Economy	$96	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/29/2026 7:10:00 AM to RaceTrac Gas Station, Port Saint Lucie, FL (USA) arriving at 7/30/2026 3:15:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 20h 5m
Greyhound US	14h 45m	8:20 PM	Greenville, SC	Woodruff Rd	11:05 AM	Port Saint Lucie, FL	RaceTrac Gas Station	Economy	$135	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/29/2026 8:20:00 PM to RaceTrac Gas Station, Port Saint Lucie, FL (USA) arriving at 7/30/2026 11:05:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 14h 45m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 45m	8:20 PM	Greenville, SC	Woodruff Rd	11:05 AM	Port Saint Lucie, FL	RaceTrac Gas Station	Economy	$101	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/30/2026 8:20:00 PM to RaceTrac Gas Station, Port Saint Lucie, FL (USA) arriving at 7/31/2026 11:05:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 14h 45m
Greyhound US	16h 0m	11:15 AM	Greenville, SC	Woodruff Rd	3:15 AM	Port Saint Lucie, FL	RaceTrac Gas Station	Economy	$106	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/30/2026 11:15:00 AM to RaceTrac Gas Station, Port Saint Lucie, FL (USA) arriving at 7/31/2026 3:15:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 16h 0m
FlixBus	28h 0m	9:35 PM	Greenville, SC	Woodruff Rd	1:35 AM	Port Saint Lucie, FL	RaceTrac Gas Station	Economy	$110	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 7/30/2026 9:35:00 PM to RaceTrac Gas Station, Port Saint Lucie, FL (USA) arriving at 8/1/2026 1:35:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 28h 0m

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	14h 45m	8:20 PM	Greenville, SC	Woodruff Rd	11:05 AM	Port Saint Lucie, FL	SW Gatlin Blvd & SW Brescia St Bus Stop		Economy	$101	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/31/2026 8:20:00 PM to SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) arriving at 8/1/2026 11:05:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 14h 45m
	Greyhound US	16h 0m	11:15 AM	Greenville, SC	Woodruff Rd	3:15 AM	Port Saint Lucie, FL	SW Gatlin Blvd & SW Brescia St Bus Stop		Economy	$103	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/31/2026 11:15:00 AM to SW Gatlin Blvd & SW Brescia St Bus Stop, Port Saint Lucie, FL (USA) arriving at 8/1/2026 3:15:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 16h 0m

Best Price Offer: The price for the cheapest bus from Greenville, SC to Port Saint Lucie, FL is $80 on 7/26/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Greenville, SC and Port Saint Lucie, FL

See here how frequent the connections between Greenville, SC and Port Saint Lucie, FL are, during different times and days of the week.

Sunday is the busiest day, with more than 6 daily buses from Greenville, SC to Port Saint Lucie, FL. Monday has instead the fewest connections, with only 2 daily coaches between Greenville, SC and Port Saint Lucie, FL.

The busiest time of the day is the Evening, with 14 buses from Greenville, SC to Port Saint Lucie, FL, while Morning sees the fewest connections between Greenville, SC and Port Saint Lucie, FL, with 8 offers.

Facts about the bus from Greenville, SC to Port Saint Lucie, FL

Compare all providers like Greyhound US and FlixBus that travel 3 times every day by bus from Greenville, SC to Port Saint Lucie, FL in one click! Book your bus ticket from Greenville, SC to Port Saint Lucie, FL starting from $80!

Cheapest Bus	$80
Fastest Bus	14h 45m
Earliest Bus	11:15 AM
Latest Bus	8:20 PM
Daily Bus Routes	3 Ø
Distance	537.5 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Greenville, SC to Port Saint Lucie, FL

Every day, 3 buses from 2 bus companies leave Greenville, SC for Port Saint Lucie, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

$80

Monday 07/27

$86

Tuesday 07/28

$93

Wednesday 07/29

$95

Thursday 07/30

$101

Friday 07/31

$101

Saturday 08/01

Sunday 08/02

Monday 08/03

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

$83

Friday 08/07

$88

Saturday 08/08

Sunday 08/09

$90

Monday 08/10

$90

Tuesday 08/11

$84

Wednesday 08/12

$91

Thursday 08/13

Friday 08/14

Saturday 08/15

Sunday 08/16

Monday 08/17

Tuesday 08/18

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

The cheapest time to travel from Greenville, SC to Port Saint Lucie, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Port Saint Lucie, FL, for the next 30 days.

With a price starting from $80, Sunday is the cheapest day for a bus from Greenville, SC to Port Saint Lucie, FL. Wednesday instead is the most expensive day with prices starting from $91.

Morning is the cheapest day time for bus tickets from Greenville, SC to Port Saint Lucie, FL, with $80. Evening is the most expensive time of the day with prices starting from $83.

How to save money travelling from Greenville, SC to Port Saint Lucie, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Port Saint Lucie, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Port Saint Lucie, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Port Saint Lucie, FL are also emptier.

All bus stations and stops in Greenville, SC and Port Saint Lucie, FL

In the map below, you can see where to find all bus stations in Greenville, SC and Port Saint Lucie, FL.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Greyhound Bus Station

Hendrix Dr 9

N Church St

Guadalajara Supermarket

White Horse Rd 2803

Fort Pierce Service Plaza

Florida Turnpike Mile Marker 144

SW Gatlin Blvd & SW Brescia St Bus Stop

RaceTrac Gas Station

SW Gatlin Blvd 2031

Shell Gas Station

SW Saint Lucie West Blvd 1795

Service and Comfort on the bus from Greenville, SC to Port Saint Lucie, FL

Want to know which seat classes are available on the buses from Greenville, SC to Port Saint Lucie, FL? Or which bus companies serve the route Greenville, SC to Port Saint Lucie, FL? Below you will find answers to your questions.

FAQs about the Greenville, SC to Port Saint Lucie, FL bus

How much does a Greenville, SC Port Saint Lucie, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $80 and takes 16h 0m to reach Port Saint Lucie, FL. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Port Saint Lucie, FL?

This route is offered by 2 companies with a range of ticket prices between $80 and $135. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Port Saint Lucie, FL.

On average, how many connections are available from Greenville, SC to Port Saint Lucie, FL each day?

Every day, the Greenville, SC to Port Saint Lucie, FL bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Port Saint Lucie, FL take?

The fastest bus from Greenville, SC to Port Saint Lucie, FL is offered by Greyhound US and takes 14h 45m. Bus tickets for this connection cost $103. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Port Saint Lucie, FL?

The earliest bus arriving in Port Saint Lucie, FL from Greenville, SC starts at 11:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Port Saint Lucie, FL?

The latest bus trip departing from Greenville, SC for Port Saint Lucie, FL starts at 8:20 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Port Saint Lucie, FL route?

When traveling by bus from Greenville, SC to Port Saint Lucie, FL, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Port Saint Lucie, FL?

You can check all the direct connections between Greenville, SC and Port Saint Lucie, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Greenville, SC to Port Saint Lucie, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Port Saint Lucie, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Port Saint Lucie, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Port Saint Lucie, FL on your planned travel date.

Available seat classes which are offered on the bus route Greenville, SC to Port Saint Lucie, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Port Saint Lucie, FL

Here’s an overview of the most popular bus routes to Greenville, SC and to Port Saint Lucie, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!