Bus Greenville, SC to Gainesville, FL: Compare prices and save money

Compare all timetables for the bus from Greenville, SC to Gainesville, FL

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Gainesville, FL from various bus operators like Greyhound US, FlixBus or Tornado Bus Company for the next days.

today

$58

tomorrow

Monday

Tuesday

$59

Wednesday

$67

Thursday

Friday

$57

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	10h 0m	11:15 AM	Greenville, SC	Woodruff Rd	9:15 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$58	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/25/2026 11:15:00 AM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 7/25/2026 9:15:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 10h 0m
Greyhound US	12h 55m	2:45 PM	Greenville, SC	Woodruff Rd	3:40 AM	Gainesville, FL	Rosa Parks Transfer station	Economy	$58	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/25/2026 2:45:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 7/26/2026 3:40:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 12h 55m
FlixBus	15h 40m	9:35 PM	Greenville, SC	Woodruff Rd	1:15 PM	Gainesville, FL	North Walmart Supercenter Bus Stop	Economy	$61	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 7/25/2026 9:35:00 PM to North Walmart Supercenter Bus Stop, Gainesville, FL (USA) arriving at 7/26/2026 1:15:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 40m
Tornado Bus Company	19h 35m	2:30 PM	Greenville, SC	Guadalajara Supermarket	10:05 AM	Gainesville, FL	Kangaroo Express	Economy	$275	A Bus from Tornado Bus Company goes from Guadalajara Supermarket, Greenville, SC (USA) at 7/25/2026 2:30:00 PM to Kangaroo Express, Gainesville, FL (USA) arriving at 7/26/2026 10:05:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 19h 35m
Tornado Bus Company	19h 40m	2:30 PM	Greenville, SC	Guadalajara Supermarket	10:10 AM	Gainesville, FL	Kangaroo Express	Economy	$275	A Bus from Tornado Bus Company goes from Guadalajara Supermarket, Greenville, SC (USA) at 7/25/2026 2:30:00 PM to Kangaroo Express, Gainesville, FL (USA) arriving at 7/26/2026 10:10:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 19h 40m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	10h 0m	11:15 AM	Greenville, SC	Woodruff Rd	9:15 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$59	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/28/2026 11:15:00 AM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 7/28/2026 9:15:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 10h 0m
Greyhound US	12h 55m	2:45 PM	Greenville, SC	Woodruff Rd	3:40 AM	Gainesville, FL	Rosa Parks Transfer station	Economy	$59	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/28/2026 2:45:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 7/29/2026 3:40:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 12h 55m
FlixBus	15h 40m	9:35 PM	Greenville, SC	Woodruff Rd	1:15 PM	Gainesville, FL	North Walmart Supercenter Bus Stop	Economy	$61	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 7/28/2026 9:35:00 PM to North Walmart Supercenter Bus Stop, Gainesville, FL (USA) arriving at 7/29/2026 1:15:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 40m
Tornado Bus Company	19h 35m	2:30 PM	Greenville, SC	Guadalajara Supermarket	10:05 AM	Gainesville, FL	Kangaroo Express	Economy	$275	A Bus from Tornado Bus Company goes from Guadalajara Supermarket, Greenville, SC (USA) at 7/28/2026 2:30:00 PM to Kangaroo Express, Gainesville, FL (USA) arriving at 7/29/2026 10:05:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 19h 35m
Tornado Bus Company	19h 40m	2:30 PM	Greenville, SC	Guadalajara Supermarket	10:10 AM	Gainesville, FL	Kangaroo Express	Economy	$275	A Bus from Tornado Bus Company goes from Guadalajara Supermarket, Greenville, SC (USA) at 7/28/2026 2:30:00 PM to Kangaroo Express, Gainesville, FL (USA) arriving at 7/29/2026 10:10:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 19h 40m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	12h 55m	2:45 PM	Greenville, SC	Woodruff Rd	3:40 AM	Gainesville, FL	Rosa Parks Transfer station	Economy	$67	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/29/2026 2:45:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 7/30/2026 3:40:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 12h 55m
FlixBus	15h 40m	9:35 PM	Greenville, SC	Woodruff Rd	1:15 PM	Gainesville, FL	Greyhound Bus Station	Economy	$68	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 7/29/2026 9:35:00 PM to Greyhound Bus Station, Gainesville, FL (USA) arriving at 7/30/2026 1:15:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 15h 40m
Greyhound US	8h 55m	8:20 PM	Greenville, SC	Woodruff Rd	5:15 AM	Gainesville, FL	Rosa Parks Transfer station	Economy	$82	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/29/2026 8:20:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 7/30/2026 5:15:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 8h 55m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	8h 55m	8:20 PM	Greenville, SC	Woodruff Rd	5:15 AM	Gainesville, FL	Rosa Parks Transfer station	Economy	$57	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/31/2026 8:20:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 8/1/2026 5:15:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 8h 55m
Greyhound US	12h 55m	2:45 PM	Greenville, SC	Woodruff Rd	3:40 AM	Gainesville, FL	Rosa Parks Transfer station	Economy	$58	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/31/2026 2:45:00 PM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 8/1/2026 3:40:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 12h 55m
Greyhound US	10h 0m	11:15 AM	Greenville, SC	Woodruff Rd	9:15 PM	Gainesville, FL	Rosa Parks Transfer station	Economy	$60	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 7/31/2026 11:15:00 AM to Rosa Parks Transfer station, Gainesville, FL (USA) arriving at 7/31/2026 9:15:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 10h 0m
FlixBus	15h 40m	9:35 PM	Greenville, SC	Woodruff Rd	1:15 PM	Gainesville, FL	Greyhound Bus Station	Economy	$63	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 7/31/2026 9:35:00 PM to Greyhound Bus Station, Gainesville, FL (USA) arriving at 8/1/2026 1:15:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 15h 40m

Frequency of bus connections between Greenville, SC and Gainesville, FL

See here how frequent the connections between Greenville, SC and Gainesville, FL are, during different times and days of the week.

Tuesday is the busiest day, with more than 10 daily buses from Greenville, SC to Gainesville, FL. Wednesday has instead the fewest connections, with only 3 daily coaches between Greenville, SC and Gainesville, FL.

The busiest time of the day is the Evening, with 10 buses from Greenville, SC to Gainesville, FL, while Morning sees the fewest connections between Greenville, SC and Gainesville, FL, with 4 offers.

Test cheapest views

The cheapest bus for the 7/26/2026 costs just $54, from Greyhound US

Facts about the bus from Greenville, SC to Gainesville, FL

Compare all providers like Greyhound US, FlixBus and Tornado Bus Company that travel 5 times every day by bus from Greenville, SC to Gainesville, FL in one click! Book your bus ticket from Greenville, SC to Gainesville, FL starting from $54!

Cheapest Bus	$54
Fastest Bus	8h 55m
Earliest Bus	11:15 AM
Latest Bus	9:35 PM
Daily Bus Routes	5 Ø
Distance	359.9 miles
Bus Companies	Greyhound US, FlixBus and Tornado Bus Company

Cheapest bus connections from Greenville, SC to Gainesville, FL

Every day, 5 buses from 3 bus companies leave Greenville, SC for Gainesville, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

$58

Sunday 07/26

$54

Monday 07/27

Tuesday 07/28

$59

Wednesday 07/29

$67

Thursday 07/30

Friday 07/31

$57

Saturday 08/01

$71

Sunday 08/02

Monday 08/03

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

$59

Friday 08/07

Saturday 08/08

$61

Sunday 08/09

Monday 08/10

$55

Tuesday 08/11

$61

Wednesday 08/12

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from Greenville, SC to Gainesville, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Gainesville, FL, for the next 30 days.

With a price starting from $57, Friday is the cheapest day for a bus from Greenville, SC to Gainesville, FL. Wednesday instead is the most expensive day with prices starting from $67.

Evening is the cheapest day time for bus tickets from Greenville, SC to Gainesville, FL, with $57. Morning is the most expensive time of the day with prices starting from $58.

How to save money travelling from Greenville, SC to Gainesville, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Gainesville, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Gainesville, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Gainesville, FL are also emptier.

All bus stations and stops in Greenville, SC and Gainesville, FL

In the map below, you can see where to find all bus stations in Greenville, SC and Gainesville, FL.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Greyhound Bus Station

Hendrix Dr 9

N Church St

Guadalajara Supermarket

White Horse Rd 2803

Rosa Parks Transfer station

SE 3rd St 700

Greyhound Bus Station

Northeast 23rd Avenue 101

Central Bus Station

North Walmart Supercenter Bus Stop

Westgate Plaza Bus Stop

Service and Comfort on the bus from Greenville, SC to Gainesville, FL

Want to know which seat classes are available on the buses from Greenville, SC to Gainesville, FL? Or which bus companies serve the route Greenville, SC to Gainesville, FL? Below you will find answers to your questions.

FAQs about the Greenville, SC to Gainesville, FL bus

How much does a Greenville, SC Gainesville, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $54 and takes 8h 55m to reach Gainesville, FL. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Gainesville, FL?

This route is offered by 3 companies with a range of ticket prices between $54 and $275. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Gainesville, FL.

On average, how many connections are available from Greenville, SC to Gainesville, FL each day?

Every day, the Greenville, SC to Gainesville, FL bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Gainesville, FL take?

The fastest bus from Greenville, SC to Gainesville, FL is offered by Greyhound US and takes 8h 55m. Bus tickets for this connection cost $72. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Gainesville, FL?

The earliest bus arriving in Gainesville, FL from Greenville, SC starts at 11:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Gainesville, FL?

The latest bus trip departing from Greenville, SC for Gainesville, FL starts at 9:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Gainesville, FL route?

When traveling by bus from Greenville, SC to Gainesville, FL, passengers can travel with Greyhound US, FlixBus and Tornado Bus Company. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Gainesville, FL?

You can check all the direct connections between Greenville, SC and Gainesville, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US, FlixBus and Tornado Bus Company.

What can I take with me on the Greenville, SC to Gainesville, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Gainesville, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Gainesville, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Gainesville, FL on your planned travel date.

Available seat classes which are offered on the bus route Greenville, SC to Gainesville, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Gainesville, FL

Here’s an overview of the most popular bus routes to Greenville, SC and to Gainesville, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!