Bus Santiago, RM to Santa Cruz, LI: Compare prices and save money

Compare all timetables for the bus from Santiago, RM to Santa Cruz, LI

Here is a selection of the cheapest bus trips from the schedule from Santiago, RM to Santa Cruz, LI from various bus operators like FlixBus or Nueva Andimar Vip for the next days.

today

tomorrow

Tuesday

Wednesday

Thursday

Friday

Saturday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	2h 40m	5:59 PM	Santiago, RM	Sur Bus Station	8:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/26/2026 5:59:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/26/2026 8:39:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	6:59 PM	Santiago, RM	Sur Bus Station	9:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/26/2026 6:59:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/26/2026 9:39:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	7:29 PM	Santiago, RM	Sur Bus Station	10:09 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/26/2026 7:29:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/26/2026 10:09:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 40m	1:59 PM	Santiago, RM	Sur Bus Station	4:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$9	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 7/26/2026 1:59:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/26/2026 4:39:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 45m	4:59 PM	Santiago, RM	Sur Bus Station	7:44 PM	Santa Cruz, LI	Central Bus Station	Economy	$9	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 7/26/2026 4:59:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/26/2026 7:44:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	2h 40m	6:15 AM	Santiago, RM	Sur Bus Station	8:55 AM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/28/2026 6:15:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/28/2026 8:55:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	8:59 AM	Santiago, RM	Sur Bus Station	11:39 AM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/28/2026 8:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/28/2026 11:39:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	9:59 AM	Santiago, RM	Sur Bus Station	12:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/28/2026 9:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/28/2026 12:39:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	10:59 AM	Santiago, RM	Sur Bus Station	1:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/28/2026 10:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/28/2026 1:39:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	11:29 AM	Santiago, RM	Sur Bus Station	2:09 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/28/2026 11:29:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/28/2026 2:09:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	2h 40m	6:15 AM	Santiago, RM	Sur Bus Station	8:55 AM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/29/2026 6:15:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/29/2026 8:55:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	8:59 AM	Santiago, RM	Sur Bus Station	11:39 AM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/29/2026 8:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/29/2026 11:39:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	9:59 AM	Santiago, RM	Sur Bus Station	12:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/29/2026 9:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/29/2026 12:39:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	10:59 AM	Santiago, RM	Sur Bus Station	1:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/29/2026 10:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/29/2026 1:39:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	11:29 AM	Santiago, RM	Sur Bus Station	2:09 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/29/2026 11:29:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/29/2026 2:09:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	2h 40m	6:15 AM	Santiago, RM	Sur Bus Station	8:55 AM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/30/2026 6:15:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/30/2026 8:55:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	8:59 AM	Santiago, RM	Sur Bus Station	11:39 AM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/30/2026 8:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/30/2026 11:39:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	9:59 AM	Santiago, RM	Sur Bus Station	12:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/30/2026 9:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/30/2026 12:39:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	10:59 AM	Santiago, RM	Sur Bus Station	1:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/30/2026 10:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/30/2026 1:39:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	11:29 AM	Santiago, RM	Sur Bus Station	2:09 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 7/30/2026 11:29:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/30/2026 2:09:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Nueva Andimar Vip	2h 40m	6:15 AM	Santiago, RM	Sur Bus Station	8:55 AM	Santa Cruz, LI	Central Bus Station	Economy	$9	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 8/1/2026 6:15:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 8/1/2026 8:55:00 AM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 40m	8:59 AM	Santiago, RM	Sur Bus Station	11:39 AM	Santa Cruz, LI	Central Bus Station	Economy	$9	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 8/1/2026 8:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 8/1/2026 11:39:00 AM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 40m	9:59 AM	Santiago, RM	Sur Bus Station	12:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$9	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 8/1/2026 9:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 8/1/2026 12:39:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 40m	10:59 AM	Santiago, RM	Sur Bus Station	1:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$9	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 8/1/2026 10:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 8/1/2026 1:39:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 40m	11:29 AM	Santiago, RM	Sur Bus Station	2:09 PM	Santa Cruz, LI	Central Bus Station	Economy	$9	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 8/1/2026 11:29:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 8/1/2026 2:09:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 40m

Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than $1? You can find the corresponding connections below.
- Nueva Andimar Vip
  
  2h 40m
  
  0
  
  6:15 AM
  
  Santiago, RM
  Sur Bus Station
  
  8:00 AM
  
  San Fernando, LI
  Central Bus Station
  
  0
  
  Economy
  
  $6
  
  A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 7/30/2026 6:15:00 AM to Central Bus Station, San Fernando, LI (Chile) arriving at 7/30/2026 8:00:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 1h 45m
- Nueva Andimar Vip
  
  0h 50m
  
  0
  
  8:05 AM
  
  San Fernando, LI
  Central Bus Station
  
  8:55 AM
  
  Santa Cruz, LI
  Central Bus Station
  
  0
  
  Economy
  
  $2
  
  A Bus from Nueva Andimar Vip goes from Central Bus Station, San Fernando, LI (Chile) at 7/30/2026 8:05:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 7/30/2026 8:55:00 AM. 50 Economy ticket for $2 per person are available. Travel duration is 0h 50m
Travel time is the same as the direct connection, but you will save $1

Frequency of bus connections between Santiago, RM and Santa Cruz, LI

See here how frequent the connections between Santiago, RM and Santa Cruz, LI are, during different times and days of the week.

Wednesday is the busiest day, with more than 28 daily buses from Santiago, RM to Santa Cruz, LI. Tuesday has instead the fewest connections, with only 14 daily coaches between Santiago, RM and Santa Cruz, LI.

The busiest time of the day is the Morning, with 33 buses from Santiago, RM to Santa Cruz, LI, while Afternoon sees the fewest connections between Santiago, RM and Santa Cruz, LI, with 24 offers.

Test cheapest views

The cheapest bus for the 8/16/2026 costs just $6, from FlixBus

Facts about the bus from Santiago, RM to Santa Cruz, LI

Compare all providers like FlixBus and Nueva Andimar Vip that travel 17 times every day by bus from Santiago, RM to Santa Cruz, LI in one click! Book your bus ticket from Santiago, RM to Santa Cruz, LI starting from $6!

Cheapest Bus	$6
Fastest Bus	2h 40m
Earliest Bus	6:30 AM
Latest Bus	8:59 PM
Daily Bus Routes	17 Ø
Distance	91.0 miles
Bus Companies	FlixBus and Nueva Andimar Vip

Cheapest bus connections from Santiago, RM to Santa Cruz, LI

Every day, 17 buses from 2 bus companies leave Santiago, RM for Santa Cruz, LI: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

Monday 07/27

Tuesday 07/28

Wednesday 07/29

Thursday 07/30

Friday 07/31

Saturday 08/01

Sunday 08/02

Monday 08/03

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

Friday 08/07

Saturday 08/08

Sunday 08/09

Monday 08/10

Tuesday 08/11

Wednesday 08/12

Thursday 08/13

Friday 08/14

Saturday 08/15

Sunday 08/16

Monday 08/17

Tuesday 08/18

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

The cheapest time to travel from Santiago, RM to Santa Cruz, LI

See here on which day and which time of the day you can find the cheapest bus ticket from Santiago, RM to Santa Cruz, LI, for the next 30 days.

With a price starting from $6, Sunday is the cheapest day for a bus from Santiago, RM to Santa Cruz, LI. Wednesday instead is the most expensive day with prices starting from $8.

Morning is the cheapest day time for bus tickets from Santiago, RM to Santa Cruz, LI, with $8. Morning is the most expensive time of the day with prices starting from $8.

How to save money travelling from Santiago, RM to Santa Cruz, LI

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santiago, RM to Santa Cruz, LI in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santiago, RM to Santa Cruz, LI, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santiago, RM to Santa Cruz, LI are also emptier.

All bus stations and stops in Santiago, RM and Santa Cruz, LI

In the map below, you can see where to find all bus stations in Santiago, RM and Santa Cruz, LI.

Sur Bus Station

Av Libertador Bernardo O'Higgins 3850

Terminal San Borja

San Francisco de Borja 198-180

Terminal Alameda

Av Libertador Bernardo O'Higgins 3750

Terminal Pajaritos

Av. Gral. Óscar Bonilla 5935-5939

Los Héroes Station

Tucapel Jiménez 22

Central Bus Station

Av. Rafael Casanova 504

Bimodal

Shell Gas Station

Hospital

La Gloria

Service and Comfort on the bus from Santiago, RM to Santa Cruz, LI

Want to know which seat classes are available on the buses from Santiago, RM to Santa Cruz, LI? Or which bus companies serve the route Santiago, RM to Santa Cruz, LI? Below you will find answers to your questions.

FAQs about the Santiago, RM to Santa Cruz, LI bus

How much does a Santiago, RM Santa Cruz, LI bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $6 and takes 2h 40m to reach Santa Cruz, LI. Compare offers to save money!

How much could I save by comparing buses from Santiago, RM to Santa Cruz, LI?

This route is offered by 2 companies with a range of ticket prices between $6 and $11. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santa Cruz, LI.

On average, how many connections are available from Santiago, RM to Santa Cruz, LI each day?

Every day, the Santiago, RM to Santa Cruz, LI bus route is served by approximately 17 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santiago, RM to Santa Cruz, LI take?

The fastest bus from Santiago, RM to Santa Cruz, LI is offered by Nueva Andimar Vip and takes 2h 40m. Bus tickets for this connection cost $9. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santiago, RM to Santa Cruz, LI?

The earliest bus arriving in Santa Cruz, LI from Santiago, RM starts at 6:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santiago, RM to Santa Cruz, LI?

The latest bus trip departing from Santiago, RM for Santa Cruz, LI starts at 8:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santiago, RM Santa Cruz, LI route?

When traveling by bus from Santiago, RM to Santa Cruz, LI, passengers can travel with FlixBus and Nueva Andimar Vip. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santiago, RM and Santa Cruz, LI?

You can check all the direct connections between Santiago, RM and Santa Cruz, LI by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Nueva Andimar Vip.

What can I take with me on the Santiago, RM to Santa Cruz, LI bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santiago, RM Santa Cruz, LI bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santiago, RM Santa Cruz, LI bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santiago, RM to Santa Cruz, LI on your planned travel date.

Available seat classes which are offered on the bus route Santiago, RM to Santa Cruz, LI

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santiago, RM and to Santa Cruz, LI

Here’s an overview of the most popular bus routes to Santiago, RM and to Santa Cruz, LI. Simply click on the connection of your choice, and you will find all the details about your bus route!