Bus Portland, ME to Knoxville, TN: Compare prices and save money

Compare all timetables for the bus from Portland, ME to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Portland, ME to Knoxville, TN from various bus operators like FlixBus or Greyhound US for the next days.

today

$104

tomorrow

$93

Tuesday

$89

Wednesday

Thursday

$100

Friday

Saturday

$121

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	42h 1m	11:59 PM	Portland, ME	City Hall	6:00 PM	Knoxville, TN	Greyhound Bus Station		Economy	$104	A Bus from FlixBus goes from City Hall, Portland, ME (USA) at 7/26/2026 11:59:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/28/2026 6:00:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 42h 1m
	Greyhound US	28h 15m	1:45 PM	Portland, ME	City Hall	6:00 PM	Knoxville, TN	Greyhound Bus Station		Economy	$107	A Bus from Greyhound US goes from City Hall, Portland, ME (USA) at 7/26/2026 1:45:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/27/2026 6:00:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 28h 15m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	28h 15m	1:45 PM	Portland, ME	City Hall	6:00 PM	Knoxville, TN	Greyhound Bus Station		Economy	$93	A Bus from Greyhound US goes from City Hall, Portland, ME (USA) at 7/27/2026 1:45:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/28/2026 6:00:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 28h 15m
	FlixBus	42h 1m	11:59 PM	Portland, ME	City Hall	6:00 PM	Knoxville, TN	Greyhound Bus Station		Economy	$106	A Bus from FlixBus goes from City Hall, Portland, ME (USA) at 7/27/2026 11:59:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/29/2026 6:00:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 42h 1m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	28h 15m	1:45 PM	Portland, ME	City Hall	6:00 PM	Knoxville, TN	Greyhound Bus Station		Economy	$89	A Bus from Greyhound US goes from City Hall, Portland, ME (USA) at 7/28/2026 1:45:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/29/2026 6:00:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 28h 15m
	FlixBus	42h 1m	11:59 PM	Portland, ME	City Hall	6:00 PM	Knoxville, TN	Greyhound Bus Station		Economy	$92	A Bus from FlixBus goes from City Hall, Portland, ME (USA) at 7/28/2026 11:59:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 7/30/2026 6:00:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 42h 1m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	28h 15m	1:45 PM	Portland, ME	Bus Stop	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$100	A Bus from Greyhound US goes from Bus Stop, Portland, ME (USA) at 7/30/2026 1:45:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 7/31/2026 6:00:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 28h 15m
	FlixBus	42h 1m	11:59 PM	Portland, ME	Bus Stop	6:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop		Economy	$100	A Bus from FlixBus goes from Bus Stop, Portland, ME (USA) at 7/30/2026 11:59:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 8/1/2026 6:00:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 42h 1m

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	42h 1m	11:59 PM	Portland, ME	City Hall	6:00 PM	Knoxville, TN	Greyhound Bus Station		Economy	$121	A Bus from FlixBus goes from City Hall, Portland, ME (USA) at 8/1/2026 11:59:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 8/3/2026 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 42h 1m
	Greyhound US	28h 15m	1:45 PM	Portland, ME	City Hall	6:00 PM	Knoxville, TN	Greyhound Bus Station		Economy	$123	A Bus from Greyhound US goes from City Hall, Portland, ME (USA) at 8/1/2026 1:45:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 8/2/2026 6:00:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 28h 15m

Frequency of bus connections between Portland, ME and Knoxville, TN

See here how frequent the connections between Portland, ME and Knoxville, TN are, during different times and days of the week.

Sunday is the busiest day, with more than 2 daily buses from Portland, ME to Knoxville, TN. Sunday has instead the fewest connections, with only 2 daily coaches between Portland, ME and Knoxville, TN.

The busiest time of the day is the Afternoon, with 5 buses from Portland, ME to Knoxville, TN, while Afternoon sees the fewest connections between Portland, ME and Knoxville, TN, with 5 offers.

Test cheapest views

The cheapest bus for the 7/27/2026 costs just $89, from Greyhound US

Facts about the bus from Portland, ME to Knoxville, TN

Compare all providers like FlixBus and Greyhound US that travel 2 times every day by bus from Portland, ME to Knoxville, TN in one click! Book your bus ticket from Portland, ME to Knoxville, TN starting from $89!

Cheapest Bus	$89
Fastest Bus	28h 15m
Earliest Bus	1:45 PM
Latest Bus	11:59 PM
Daily Bus Routes	2 Ø
Distance	895.6 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Portland, ME to Knoxville, TN

Every day, 2 buses from 2 bus companies leave Portland, ME for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/26

$104

Monday 07/27

$89

Tuesday 07/28

$89

Wednesday 07/29

Thursday 07/30

$100

Friday 07/31

Saturday 08/01

$121

Sunday 08/02

Monday 08/03

$100

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

$106

Friday 08/07

$124

Saturday 08/08

Sunday 08/09

$122

Monday 08/10

Tuesday 08/11

$97

Wednesday 08/12

Thursday 08/13

Friday 08/14

Saturday 08/15

Sunday 08/16

Monday 08/17

Tuesday 08/18

Wednesday 08/19

Thursday 08/20

Friday 08/21

Saturday 08/22

The cheapest time to travel from Portland, ME to Knoxville, TN

See here on which day and which time of the day you can find the cheapest bus ticket from Portland, ME to Knoxville, TN, for the next 30 days.

With a price starting from $89, Monday is the cheapest day for a bus from Portland, ME to Knoxville, TN. Saturday instead is the most expensive day with prices starting from $121.

Afternoon is the cheapest day time for bus tickets from Portland, ME to Knoxville, TN, with $89. Evening is the most expensive time of the day with prices starting from $92.

How to save money travelling from Portland, ME to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Portland, ME to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Portland, ME to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Portland, ME to Knoxville, TN are also emptier.

All bus stations and stops in Portland, ME and Knoxville, TN

In the map below, you can see where to find all bus stations in Portland, ME and Knoxville, TN.

City Hall

Congress St 389

Transportation Center

Thompson's Point Rd 100

Bus Stop

Congress St 950

Maine Mall Rd

Maine Mall Rd 357

Park and Ride

Marginal Way 264

Kingston Pike

Kingston Pike 6927

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Greyhound Bus Station

E Magnolia Ave 100

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Transit Center

E Church Ave 301

Service and Comfort on the bus from Portland, ME to Knoxville, TN

Want to know which seat classes are available on the buses from Portland, ME to Knoxville, TN? Or which bus companies serve the route Portland, ME to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Portland, ME to Knoxville, TN bus

How much does a Portland, ME Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $89 and takes 28h 15m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Portland, ME to Knoxville, TN?

This route is offered by 2 companies with a range of ticket prices between $89 and $123. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Portland, ME to Knoxville, TN each day?

Every day, the Portland, ME to Knoxville, TN bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Portland, ME to Knoxville, TN take?

The fastest bus from Portland, ME to Knoxville, TN is offered by Greyhound US and takes 28h 15m. Bus tickets for this connection cost $107. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Portland, ME to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Portland, ME starts at 1:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Portland, ME to Knoxville, TN?

The latest bus trip departing from Portland, ME for Knoxville, TN starts at 11:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Portland, ME Knoxville, TN route?

When traveling by bus from Portland, ME to Knoxville, TN, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Portland, ME and Knoxville, TN?

You can check all the direct connections between Portland, ME and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Portland, ME to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Portland, ME Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Portland, ME Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Portland, ME to Knoxville, TN on your planned travel date.

Available seat classes which are offered on the bus route Portland, ME to Knoxville, TN

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Portland, ME and to Knoxville, TN

Here’s an overview of the most popular bus routes to Portland, ME and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!