Bus Lyon to Prague - Compare all Companies

Compare all timetables for the bus from Lyon to Prague

Here is a selection of the cheapest bus trips from the schedule from Lyon to Prague from various bus operators like FlixBus or BlaBlaCar Bus for the next days.

today

$69

tomorrow

$73

Friday

$80

Saturday

$86

Sunday

$90

Monday

$78

Tuesday

$67

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 15m	6:05 PM	Lyon	11:20 AM	Prague	Wilsonova Bus Station	Economy	$69	A Bus from FlixBus goes from , Lyon (France) at 7/22/2026 6:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/23/2026 11:20:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 17h 15m
FlixBus	14h 50m	6:05 PM	Lyon	8:55 AM	Prague	Na Knížecí Station	Economy	$71	A Bus from FlixBus goes from , Lyon (France) at 7/22/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/23/2026 8:55:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 14h 50m
FlixBus	15h 15m	6:05 PM	Lyon	9:20 AM	Prague	ÚAN Florenc	Economy	$71	A Bus from FlixBus goes from , Lyon (France) at 7/22/2026 6:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/23/2026 9:20:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 15h 15m
FlixBus	17h 5m	9:30 PM	Lyon	2:35 PM	Prague	Wilsonova Bus Station	Economy	$75	A Bus from FlixBus goes from , Lyon (France) at 7/22/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/23/2026 2:35:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 5m
FlixBus	17h 15m	9:30 PM	Lyon	2:45 PM	Prague	ÚAN Florenc	Economy	$75	A Bus from FlixBus goes from , Lyon (France) at 7/22/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/23/2026 2:45:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 15m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 30m	5:20 AM	Lyon	9:50 PM	Prague	ÚAN Florenc	Economy	$73	A Bus from FlixBus goes from , Lyon (France) at 7/23/2026 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/23/2026 9:50:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 16h 30m
FlixBus	14h 50m	6:05 PM	Lyon	8:55 AM	Prague	Na Knížecí Station	Economy	$75	A Bus from FlixBus goes from , Lyon (France) at 7/23/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/24/2026 8:55:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 14h 50m
FlixBus	15h 15m	6:05 PM	Lyon	9:20 AM	Prague	ÚAN Florenc	Economy	$75	A Bus from FlixBus goes from , Lyon (France) at 7/23/2026 6:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/24/2026 9:20:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 15m
FlixBus	19h 25m	5:20 AM	Lyon	12:45 AM	Prague	Wilsonova Bus Station	Economy	$79	A Bus from FlixBus goes from , Lyon (France) at 7/23/2026 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/24/2026 12:45:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 19h 25m
FlixBus	17h 35m	5:20 AM	Lyon	10:55 PM	Prague	Na Knížecí Station	Economy	$80	A Bus from FlixBus goes from , Lyon (France) at 7/23/2026 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/23/2026 10:55:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 17h 35m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 30m	5:20 AM	Lyon		9:50 PM	Prague	ÚAN Florenc	Economy	$80	A Bus from FlixBus goes from , Lyon (France) at 7/24/2026 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/24/2026 9:50:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 16h 30m
FlixBus	17h 35m	5:20 AM	Lyon		10:55 PM	Prague	Na Knížecí Station	Economy	$88	A Bus from FlixBus goes from , Lyon (France) at 7/24/2026 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/24/2026 10:55:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 17h 35m
FlixBus	19h 25m	5:20 AM	Lyon		12:45 AM	Prague	Wilsonova Bus Station	Economy	$89	A Bus from FlixBus goes from , Lyon (France) at 7/24/2026 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/25/2026 12:45:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 19h 25m
BlaBlaCar Bus	18h 50m	2:55 PM	Lyon	Perrache Train Station	9:45 AM	Prague	ÚAN Florenc	Economy	$91	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 7/24/2026 2:55:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/25/2026 9:45:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 18h 50m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Arrival time	To	Destination	Seat classes	Price
FlixBus	19h 25m	5:20 AM	Lyon	12:45 AM	Prague	Wilsonova Bus Station	Economy	$86	A Bus from FlixBus goes from , Lyon (France) at 7/25/2026 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/26/2026 12:45:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 19h 25m
FlixBus	20h 25m	12:05 PM	Lyon	8:30 AM	Prague	Zličín	Economy	$87	A Bus from FlixBus goes from , Lyon (France) at 7/25/2026 12:05:00 PM to Zličín, Prague (Czech Republic) arriving at 7/26/2026 8:30:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 20h 25m
FlixBus	17h 35m	5:20 AM	Lyon	10:55 PM	Prague	Na Knížecí Station	Economy	$88	A Bus from FlixBus goes from , Lyon (France) at 7/25/2026 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/25/2026 10:55:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 17h 35m
FlixBus	19h 25m	12:05 PM	Lyon	7:30 AM	Prague	Hradčanská	Economy	$89	A Bus from FlixBus goes from , Lyon (France) at 7/25/2026 12:05:00 PM to Hradčanská, Prague (Czech Republic) arriving at 7/26/2026 7:30:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 19h 25m
FlixBus	17h 5m	9:30 PM	Lyon	2:35 PM	Prague	Wilsonova Bus Station	Economy	$90	A Bus from FlixBus goes from , Lyon (France) at 7/25/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/26/2026 2:35:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 17h 5m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 5m	9:30 PM	Lyon	2:35 PM	Prague	Wilsonova Bus Station	Economy	$90	A Bus from FlixBus goes from , Lyon (France) at 7/26/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/27/2026 2:35:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 17h 5m
FlixBus	14h 50m	6:05 PM	Lyon	8:55 AM	Prague	Na Knížecí Station	Economy	$90	A Bus from FlixBus goes from , Lyon (France) at 7/26/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/27/2026 8:55:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 14h 50m
FlixBus	16h 30m	5:20 AM	Lyon	9:50 PM	Prague	ÚAN Florenc	Economy	$90	A Bus from FlixBus goes from , Lyon (France) at 7/26/2026 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/26/2026 9:50:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 16h 30m
FlixBus	15h 15m	6:05 PM	Lyon	9:20 AM	Prague	ÚAN Florenc	Economy	$90	A Bus from FlixBus goes from , Lyon (France) at 7/26/2026 6:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/27/2026 9:20:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 15h 15m
FlixBus	17h 15m	9:30 PM	Lyon	2:45 PM	Prague	ÚAN Florenc	Economy	$90	A Bus from FlixBus goes from , Lyon (France) at 7/26/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/27/2026 2:45:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 17h 15m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 35m	5:20 AM	Lyon	10:55 PM	Prague	Na Knížecí Station	Economy	$78	A Bus from FlixBus goes from , Lyon (France) at 7/27/2026 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/27/2026 10:55:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 17h 35m
FlixBus	19h 25m	5:20 AM	Lyon	12:45 AM	Prague	Wilsonova Bus Station	Economy	$79	A Bus from FlixBus goes from , Lyon (France) at 7/27/2026 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/28/2026 12:45:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 19h 25m
FlixBus	17h 15m	6:05 PM	Lyon	11:20 AM	Prague	Wilsonova Bus Station	Economy	$79	A Bus from FlixBus goes from , Lyon (France) at 7/27/2026 6:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/28/2026 11:20:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 17h 15m
FlixBus	20h 25m	12:05 PM	Lyon	8:30 AM	Prague	Zličín	Economy	$82	A Bus from FlixBus goes from , Lyon (France) at 7/27/2026 12:05:00 PM to Zličín, Prague (Czech Republic) arriving at 7/28/2026 8:30:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 20h 25m
FlixBus	19h 45m	12:05 PM	Lyon	7:50 AM	Prague	ÚAN Florenc	Economy	$87	A Bus from FlixBus goes from , Lyon (France) at 7/27/2026 12:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/28/2026 7:50:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 19h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 25m	10:00 PM	Lyon	3:25 PM	Prague	ÚAN Florenc	Economy	$67	A Bus from FlixBus goes from , Lyon (France) at 7/28/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/29/2026 3:25:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 17h 25m
FlixBus	18h 10m	10:00 PM	Lyon	4:10 PM	Prague	Černý Most	Economy	$67	A Bus from FlixBus goes from , Lyon (France) at 7/28/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 7/29/2026 4:10:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 18h 10m
FlixBus	14h 50m	6:05 PM	Lyon	8:55 AM	Prague	Na Knížecí Station	Economy	$71	A Bus from FlixBus goes from , Lyon (France) at 7/28/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/29/2026 8:55:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 14h 50m
FlixBus	18h 45m	3:30 AM	Lyon	10:15 PM	Prague	Wilsonova Bus Station	Economy	$71	A Bus from FlixBus goes from , Lyon (France) at 7/28/2026 3:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/28/2026 10:15:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 18h 45m
FlixBus	17h 15m	6:05 PM	Lyon	11:20 AM	Prague	Wilsonova Bus Station	Economy	$71	A Bus from FlixBus goes from , Lyon (France) at 7/28/2026 6:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/29/2026 11:20:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 17h 15m

Best Price Offer: The price for the cheapest bus from Lyon to Prague is $63 on 8/4/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Lyon and Prague

See here how frequent the connections between Lyon and Prague are, during different times and days of the week.

Sunday is the busiest day, with more than 17 daily buses from Lyon to Prague. Wednesday has instead the fewest connections, with only 7 daily coaches between Lyon and Prague.

The busiest time of the day is the Evening, with 49 buses from Lyon to Prague, while Afternoon sees the fewest connections between Lyon and Prague, with 21 offers.

Facts about the bus from Lyon to Prague

Compare all providers like FlixBus and BlaBlaCar Bus that travel 14 times every day by bus from Lyon to Prague in one click! Book your bus ticket from Lyon to Prague starting from $63!

Cheapest Bus	$63
Fastest Bus	14h 50m
Earliest Bus	6:05 PM
Latest Bus	10:00 PM
Daily Bus Routes	14 Ø
Distance	535.0 miles
Bus Companies	FlixBus and BlaBlaCar Bus

Cheapest bus connections from Lyon to Prague

Every day, 14 buses from 2 bus companies leave Lyon for Prague: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

$75

Thursday 07/23

$78

Friday 07/24

$86

Saturday 07/25

$86

Sunday 07/26

$90

Monday 07/27

$83

Tuesday 07/28

$73

Wednesday 07/29

$74

Thursday 07/30

$75

Friday 07/31

$88

Saturday 08/01

$84

Sunday 08/02

$94

Monday 08/03

$73

Tuesday 08/04

$63

Wednesday 08/05

$72

Thursday 08/06

$73

Friday 08/07

$80

Saturday 08/08

$79

Sunday 08/09

$82

Monday 08/10

$73

Tuesday 08/11

$71

Wednesday 08/12

$74

Thursday 08/13

$78

Friday 08/14

$78

Saturday 08/15

The cheapest time to travel from Lyon to Prague

See here on which day and which time of the day you can find the cheapest bus ticket from Lyon to Prague, for the next 30 days.

With a price starting from $63, Tuesday is the cheapest day for a bus from Lyon to Prague. Sunday instead is the most expensive day with prices starting from $81.

Night is the cheapest day time for bus tickets from Lyon to Prague, with $63. Afternoon is the most expensive time of the day with prices starting from $72.

How to save money travelling from Lyon to Prague

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Lyon to Prague in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Lyon to Prague, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Lyon to Prague are also emptier.

Latest reviews for bus companies on the route Lyon - Prague

Théo, 11/20/2025

On débute avec 2h50 de retard cumulé à mi-chemin pour le premier car FlixBus… Correspondance du second car bien évidemment manquée, toujours avec FlixBus… Dernier transport de la journée… dommage! O ... On débute avec 2h50 de retard cumulé à mi-chemin pour le premier car FlixBus… Correspondance du second car bien évidemment manquée, toujours avec FlixBus… Dernier transport de la journée… dommage! On repassera le matin suivant… S'il nous est pas encore passé l'envie d'arriver à destination… Toujours en suppléments à ses frais… s'il vous plaît bien sûr! Certains apprécieraient peut-être ce type d'aventure surprise… À se retrouver paumé au beau milieu de la nuit à 500km de chez soi… À moitié assommé d'une première étape de trajet complètement hasardeuse… Lâché dans une ville inconnue depuis un car douteux approchant les 3h du matin. Résultat miraculeux : Finalement arrivé à destination… à l'état de zombie certes… mais bien arrivé… Et sûrement pas grâce à cette enseigne… pour le fait de réagir face à la situation… Et débarquer 26h49 après l'horaire de départ contre les 9h44 initialement prévues… Le tout triplant les coûts non reconnus du voyage "low cost"… On dit merci qui ?

Pat, 8/21/2024

Najbardziej słabe jest robienie zdjęć pasażerom..Czy chcecie zeby ktos z pasażerow został zamordowany... Akurat to jest przestepstwo...

All bus stations and stops in Lyon and Prague

In the map below, you can see where to find all bus stations in Lyon and Prague.

Perrache Bus Stop

Cours de Verdun 14

Saint Paul Train Station

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Maison Carrée Bus Stop

Les Charrières 69570

Girondins - Yves Farge Bus Stop

Na Knížecí Station

Za Ženskými domovy / Ostrovského

ÚAN Florenc

Křižíkova 279

Wilsonova Bus Station

Wilsonova 300/8

Roztyly

Tomíčkova 2234

Hradčanská

Milady Horákové 115/107

Service and Comfort on the bus from Lyon to Prague

Want to know which seat classes are available on the buses from Lyon to Prague? Or which bus companies serve the route Lyon to Prague? Below you will find answers to your questions.

FAQs about the Lyon to Prague bus

How much does a Lyon Prague bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $63 and takes 17h 25m to reach Prague. Compare offers to save money!

How much could I save by comparing buses from Lyon to Prague?

This route is offered by 2 companies with a range of ticket prices between $63 and $187. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Prague.

On average, how many connections are available from Lyon to Prague each day?

Every day, the Lyon to Prague bus route is served by approximately 14 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Lyon to Prague take?

The fastest bus from Lyon to Prague is offered by FlixBus and takes 14h 50m. Bus tickets for this connection cost $71. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Lyon to Prague?

The earliest bus arriving in Prague from Lyon starts at 6:05 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Lyon to Prague?

The latest bus trip departing from Lyon for Prague starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Lyon Prague route?

When traveling by bus from Lyon to Prague, passengers can travel with FlixBus and BlaBlaCar Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Lyon and Prague?

You can check all the direct connections between Lyon and Prague by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and BlaBlaCar Bus.

What can I take with me on the Lyon to Prague bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Lyon Prague bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Lyon Prague bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Lyon to Prague on your planned travel date.

Available seat classes which are offered on the bus route Lyon to Prague

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Lyon and to Prague

Here’s an overview of the most popular bus routes to Lyon and to Prague. Simply click on the connection of your choice, and you will find all the details about your bus route!