Bus La Serena to Antofagasta: Compare prices and save money

Compare all timetables for the bus from La Serena to Antofagasta

Here is a selection of the cheapest bus trips from the schedule from La Serena to Antofagasta from various bus operators like Pullman San Andres, Pullman Bus or Cormar Bus for the next days.

today

$32

tomorrow

Friday

$30

Saturday

Sunday

$35

Monday

Tuesday

$35

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 35m	2:00 PM	La Serena	Central Bus Station	1:35 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$32	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 9/9/2026 2:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/10/2026 1:35:00 AM. 50 Economy ticket for $32 per person are available. Travel duration is 11h 35m
Pluss Chile	11h 35m	2:20 PM	La Serena	Central Bus Station	1:55 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$32	A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 9/9/2026 2:20:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/10/2026 1:55:00 AM. 50 Premium Economy ticket for $32 per person are available. Travel duration is 11h 35m
Pullman San Andres	12h 10m	10:00 PM	La Serena	Central Bus Station	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$35	A Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 9/9/2026 10:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/10/2026 10:10:00 AM. 50 Premium Economy ticket for $35 per person are available. Travel duration is 12h 10m
Cormar Bus	11h 50m	2:20 PM	La Serena	Central Bus Station	2:10 AM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 9/9/2026 2:20:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 9/10/2026 2:10:00 AM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 11h 50m
Cikbus Elité	11h 30m	3:00 PM	La Serena	Central Bus Station	2:30 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$37	A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 9/9/2026 3:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/10/2026 2:30:00 AM. 50 Premium Economy ticket for $37 per person are available. Travel duration is 11h 30m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	11h 55m	10:15 PM	La Serena	Central Bus Station	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$30	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 9/11/2026 10:15:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/12/2026 10:10:00 AM. 50 Economy ticket for $30 per person are available. Travel duration is 11h 55m
Cormar Bus	11h 50m	5:55 AM	La Serena	Central Bus Station	5:45 PM	Antofagasta	Camus Bus Station	Premium Economy	$32	A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 9/11/2026 5:55:00 AM to Camus Bus Station, Antofagasta (Chile) arriving at 9/11/2026 5:45:00 PM. 50 Premium Economy ticket for $32 per person are available. Travel duration is 11h 50m
Nueva Andimar Vip	11h 35m	7:15 PM	La Serena	Central Bus Station	6:50 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$33	A Bus from Nueva Andimar Vip goes from Central Bus Station, La Serena (Chile) at 9/11/2026 7:15:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/12/2026 6:50:00 AM. 50 Economy ticket for $33 per person are available. Travel duration is 11h 35m
Pullman San Andres	12h 10m	1:30 AM	La Serena	Central Bus Station	1:40 PM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$35	A Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 9/11/2026 1:30:00 AM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/11/2026 1:40:00 PM. 50 Premium Economy ticket for $35 per person are available. Travel duration is 12h 10m
Pullman Bus	11h 50m	9:00 PM	La Serena	El Sto, 1060	8:50 AM	Antofagasta	Camus Bus Station	First Class	$36	A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 9/11/2026 9:00:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 9/12/2026 8:50:00 AM. 50 First Class ticket for $36 per person are available. Travel duration is 11h 50m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Pullman San Andres	12h 10m	10:00 PM	La Serena	Central Bus Station	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$35	A Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 9/13/2026 10:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/14/2026 10:10:00 AM. 50 Premium Economy ticket for $35 per person are available. Travel duration is 12h 10m
Pullman San Andres	12h 10m	11:30 PM	La Serena	Central Bus Station	11:40 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$35	A Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 9/13/2026 11:30:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/14/2026 11:40:00 AM. 50 Premium Economy ticket for $35 per person are available. Travel duration is 12h 10m
Cormar Bus	12h 10m	6:05 AM	La Serena	Central Bus Station	6:15 PM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 9/13/2026 6:05:00 AM to Camus Bus Station, Antofagasta (Chile) arriving at 9/13/2026 6:15:00 PM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 12h 10m
Cormar Bus	11h 50m	2:20 PM	La Serena	Central Bus Station	2:10 AM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 9/13/2026 2:20:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 9/14/2026 2:10:00 AM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 11h 50m
FlixBus	11h 35m	2:00 PM	La Serena	Central Bus Station	1:35 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Economy	$37	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 9/13/2026 2:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/14/2026 1:35:00 AM. 50 Economy ticket for $37 per person are available. Travel duration is 11h 35m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Pullman San Andres	12h 10m	10:00 PM	La Serena	Central Bus Station	10:10 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$35	A Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 9/15/2026 10:00:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/16/2026 10:10:00 AM. 50 Premium Economy ticket for $35 per person are available. Travel duration is 12h 10m
Pullman San Andres	12h 10m	11:30 PM	La Serena	Central Bus Station	11:40 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Premium Economy	$35	A Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 9/15/2026 11:30:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/16/2026 11:40:00 AM. 50 Premium Economy ticket for $35 per person are available. Travel duration is 12h 10m
FlixBus	11h 35m	8:15 PM	La Serena	Central Bus Station	7:50 AM	Antofagasta	Carlos Oviedo Cavada Bus Station	Business	$36	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 9/15/2026 8:15:00 PM to Carlos Oviedo Cavada Bus Station, Antofagasta (Chile) arriving at 9/16/2026 7:50:00 AM. 50 Business ticket for $36 per person are available. Travel duration is 11h 35m
Cormar Bus	12h 10m	6:05 AM	La Serena	Central Bus Station	6:15 PM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 9/15/2026 6:05:00 AM to Camus Bus Station, Antofagasta (Chile) arriving at 9/15/2026 6:15:00 PM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 12h 10m
Cormar Bus	11h 50m	2:20 PM	La Serena	Central Bus Station	2:10 AM	Antofagasta	Camus Bus Station	Premium Economy	$36	A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 9/15/2026 2:20:00 PM to Camus Bus Station, Antofagasta (Chile) arriving at 9/16/2026 2:10:00 AM. 50 Premium Economy ticket for $36 per person are available. Travel duration is 11h 50m

Frequency of bus connections between La Serena and Antofagasta

See here how frequent the connections between La Serena and Antofagasta are, during different times and days of the week.

Wednesday is the busiest day, with more than 63 daily buses from La Serena to Antofagasta. Tuesday has instead the fewest connections, with only 47 daily coaches between La Serena and Antofagasta.

The busiest time of the day is the Evening, with 92 buses from La Serena to Antofagasta, while Morning sees the fewest connections between La Serena and Antofagasta, with 22 offers.

Test cheapest views

The cheapest bus for the 9/22/2026 costs just $26, from FlixBus

Facts about the bus from La Serena to Antofagasta

Compare all providers like Pullman San Andres, Pullman Bus and Cormar Bus that travel 52 times every day by bus from La Serena to Antofagasta in one click! Book your bus ticket from La Serena to Antofagasta starting from $26!

Cheapest Bus	$26
Fastest Bus	10h 30m
Earliest Bus	2:00 PM
Latest Bus	11:30 PM
Daily Bus Routes	52 Ø
Distance	435.4 miles
Bus Companies	Pullman San Andres, Pullman Bus, Cormar Bus, Nueva Andimar Vip, Pluss Chile, FlixBus, Cikbus Elité and Ramos Cholele

Cheapest bus connections from La Serena to Antofagasta

Every day, 52 buses from 8 bus companies leave La Serena for Antofagasta: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/09/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

Monday 09/07

Tuesday 09/08

Wednesday 09/09

$35

Thursday 09/10

$34

Friday 09/11

$30

Saturday 09/12

$27

Sunday 09/13

$35

Monday 09/14

Tuesday 09/15

$35

Wednesday 09/16

$35

Thursday 09/17

$36

Friday 09/18

$40

Saturday 09/19

$40

Sunday 09/20

$28

Monday 09/21

$27

Tuesday 09/22

$26

Wednesday 09/23

Thursday 09/24

Friday 09/25

$28

Saturday 09/26

$32

Sunday 09/27

Monday 09/28

Tuesday 09/29

Wednesday 09/30

Thursday 10/01

Friday 10/02

Saturday 10/03

The cheapest time to travel from La Serena to Antofagasta

See here on which day and which time of the day you can find the cheapest bus ticket from La Serena to Antofagasta, for the next 30 days.

With a price starting from $26, Tuesday is the cheapest day for a bus from La Serena to Antofagasta. Wednesday instead is the most expensive day with prices starting from $32.

Night is the cheapest day time for bus tickets from La Serena to Antofagasta, with $26. Morning is the most expensive time of the day with prices starting from $36.

How to save money travelling from La Serena to Antofagasta

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from La Serena to Antofagasta in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from La Serena to Antofagasta, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from La Serena to Antofagasta are also emptier.

Latest reviews for bus companies on the route La Serena - Antofagasta

Fide Jiménez , 4/26/2026

Pésimo servicio. Pasaje a las 23:45 horas el bus no llego. A esa hora dijeron que saldría otro a las 00:40 horas que tampoco llegó. Cuando fueron mis hijas a la ventanilla las personas las atendiero ... Pésimo servicio. Pasaje a las 23:45 horas el bus no llego. A esa hora dijeron que saldría otro a las 00:40 horas que tampoco llegó. Cuando fueron mis hijas a la ventanilla las personas las atendieron super mal, cero consideración con los pasajeros, prepotentes y de mal genio. El bus llegó a una de la mañana una falta de respeto con las personas que pagamos por un servicio y que no se cumple. Pagar por impuntualidad, mal rato, espera, y no poder cumplir con los compromisos contraídos en Antofagasta. Una vergüenza esta empresa.

Scarleth, 6/15/2025

Aún voy a bordo, pero no podía dejar pasar la oportunidad de felicitar la amabilidad del personal del bus, si bien cumplen con todo los estándares de calidad que ofrecen, mi asiento tuvo un defecto y ... Aún voy a bordo, pero no podía dejar pasar la oportunidad de felicitar la amabilidad del personal del bus, si bien cumplen con todo los estándares de calidad que ofrecen, mi asiento tuvo un defecto y no se podia tirar para atrás, el auxiliar fué informado y de inmediato me resolvió usar otro asiento aunque esté fuera mas caro, incluso nos movió junto a mi pareja para que no estuvieramos separados aunque el asiento de él estaba bien. Muy agradecida por la atención desde que me subí hasta ahora que estoy rumbo a mi hogar. Muchas gracias, no todas las lineas se toman en serio el servicio al cliente, lo digo por experiencia. Un abrazo

All bus stations and stops in La Serena and Antofagasta

In the map below, you can see where to find all bus stations in La Serena and Antofagasta.

Avda. Fco de Aguirre Station

Avenida Francisco de Aguirre 410

Central Bus Station

Avenida El Santo 1475

El Sto, 1060

terminal de buses covalle bus

Rotonda

Camus Bus Station

Carlos Oviedo Cavada Bus Station

Avenida Pedro Aguirre Cerda 5750

Terminal Tur Bus

Almte. Juan José Latorre 2751

Pedro Aguirre Cerda esq. Nicolas Tirado Bus Stop

La Portada

Service and Comfort on the bus from La Serena to Antofagasta

Want to know which seat classes are available on the buses from La Serena to Antofagasta? Or which bus companies serve the route La Serena to Antofagasta? Below you will find answers to your questions.

FAQs about the La Serena to Antofagasta bus

How much does a La Serena Antofagasta bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $26 and takes 11h 55m to reach Antofagasta. Compare offers to save money!

How much could I save by comparing buses from La Serena to Antofagasta?

This route is offered by 8 companies with a range of ticket prices between $26 and $56. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Antofagasta.

On average, how many connections are available from La Serena to Antofagasta each day?

Every day, the La Serena to Antofagasta bus route is served by approximately 52 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from La Serena to Antofagasta take?

The fastest bus from La Serena to Antofagasta is offered by Cormar Bus and takes 10h 30m. Bus tickets for this connection cost $43. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from La Serena to Antofagasta?

The earliest bus arriving in Antofagasta from La Serena starts at 2:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from La Serena to Antofagasta?

The latest bus trip departing from La Serena for Antofagasta starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the La Serena Antofagasta route?

When traveling by bus from La Serena to Antofagasta, passengers can travel with Pullman San Andres, Pullman Bus and Cormar Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between La Serena and Antofagasta?

You can check all the direct connections between La Serena and Antofagasta by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Pullman San Andres, Pullman Bus and Cormar Bus.

What can I take with me on the La Serena to Antofagasta bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the La Serena Antofagasta bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the La Serena Antofagasta bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from La Serena to Antofagasta on your planned travel date.

Available seat classes which are offered on the bus route La Serena to Antofagasta

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

Business

Comfortable seating, food and drink service, accompanied generally by ticket flexibility.

First Class

Best of the best: you will find the most comfortable accommodation to work or relax during your travel.

More bus routes to La Serena and to Antofagasta

Here’s an overview of the most popular bus routes to La Serena and to Antofagasta. Simply click on the connection of your choice, and you will find all the details about your bus route!