Bus Florence, SC to Jacksonville, FL

Compare all timetables for the bus from Florence, SC to Jacksonville, FL

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Jacksonville, FL from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

Sunday

$45

Monday

Tuesday

$41

Wednesday

$41

Thursday

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	5h 10m	4:15 PM	Florence, SC	Bus Station	9:25 PM	Jacksonville, FL	Downtown Bus Stop		Economy	$45	A Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 7/26/2026 4:15:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 7/26/2026 9:25:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 10m
	Greyhound US	7h 35m	9:20 AM	Florence, SC	Bus Station	4:55 PM	Jacksonville, FL	Downtown Bus Stop		Economy	$47	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 7/26/2026 9:20:00 AM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 7/26/2026 4:55:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 35m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	5h 10m	4:15 PM	Florence, SC	Bus Station	9:25 PM	Jacksonville, FL	Downtown Bus Stop		Economy	$41	A Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 7/28/2026 4:15:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 7/28/2026 9:25:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 5h 10m
	Greyhound US	7h 35m	9:20 AM	Florence, SC	Bus Station	4:55 PM	Jacksonville, FL	Downtown Bus Stop		Economy	$43	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 7/28/2026 9:20:00 AM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 7/28/2026 4:55:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 7h 35m

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	5h 10m	4:15 PM	Florence, SC	Bus Station	9:25 PM	Jacksonville, FL	Downtown Bus Stop		Economy	$41	A Bus from FlixBus goes from Bus Station, Florence, SC (USA) at 7/29/2026 4:15:00 PM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 7/29/2026 9:25:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 5h 10m
	Greyhound US	7h 35m	9:20 AM	Florence, SC	Bus Station	4:55 PM	Jacksonville, FL	Downtown Bus Stop		Economy	$43	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 7/29/2026 9:20:00 AM to Downtown Bus Stop, Jacksonville, FL (USA) arriving at 7/29/2026 4:55:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 7h 35m

Best Price Offer: The price for the cheapest bus from Florence, SC to Jacksonville, FL is $39 on 8/6/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Florence, SC and Jacksonville, FL

See here how frequent the connections between Florence, SC and Jacksonville, FL are, during different times and days of the week.

Sunday is the busiest day, with more than 2 daily buses from Florence, SC to Jacksonville, FL. Sunday has instead the fewest connections, with only 2 daily coaches between Florence, SC and Jacksonville, FL.

The busiest time of the day is the Morning, with 3 buses from Florence, SC to Jacksonville, FL, while Morning sees the fewest connections between Florence, SC and Jacksonville, FL, with 3 offers.

Facts about the bus from Florence, SC to Jacksonville, FL

Compare all providers like Greyhound US and FlixBus that travel 2 times every day by bus from Florence, SC to Jacksonville, FL in one click! Book your bus ticket from Florence, SC to Jacksonville, FL starting from $39!

Cheapest Bus	$39
Fastest Bus	5h 10m
Earliest Bus	9:20 AM
Latest Bus	4:15 PM
Daily Bus Routes	2 Ø
Distance	289.6 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Jacksonville, FL

Every day, 2 buses from 2 bus companies leave Florence, SC for Jacksonville, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/24/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

Sunday 07/26

$44

Monday 07/27

Tuesday 07/28

$45

Wednesday 07/29

$40

Thursday 07/30

Friday 07/31

Saturday 08/01

$55

Sunday 08/02

Monday 08/03

$51

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

$39

Friday 08/07

Saturday 08/08

$52

Sunday 08/09

Monday 08/10

Tuesday 08/11

$41

Wednesday 08/12

$46

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from Florence, SC to Jacksonville, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Jacksonville, FL, for the next 30 days.

With a price starting from $40, Wednesday is the cheapest day for a bus from Florence, SC to Jacksonville, FL. Sunday instead is the most expensive day with prices starting from $44.

Afternoon is the cheapest day time for bus tickets from Florence, SC to Jacksonville, FL, with $41. Morning is the most expensive time of the day with prices starting from $43.

How to save money travelling from Florence, SC to Jacksonville, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Jacksonville, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Jacksonville, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Jacksonville, FL are also emptier.

All bus stations and stops in Florence, SC and Jacksonville, FL

In the map below, you can see where to find all bus stations in Florence, SC and Jacksonville, FL.

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Downtown Bus Stop

West Forsyth Street 1111

Beaver St. & Ocean St. Bus Stop

Central Bus Station

Old St. Augustine Rd

Old St. Augustine Rd 10584-13

Friendship Fountain

Service and Comfort on the bus from Florence, SC to Jacksonville, FL

Want to know which seat classes are available on the buses from Florence, SC to Jacksonville, FL? Or which bus companies serve the route Florence, SC to Jacksonville, FL? Below you will find answers to your questions.

FAQs about the Florence, SC to Jacksonville, FL bus

How much does a Florence, SC Jacksonville, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $39 and takes 5h 10m to reach Jacksonville, FL. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Jacksonville, FL?

This route is offered by 2 companies with a range of ticket prices between $39 and $47. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Jacksonville, FL.

On average, how many connections are available from Florence, SC to Jacksonville, FL each day?

Every day, the Florence, SC to Jacksonville, FL bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Jacksonville, FL take?

The fastest bus from Florence, SC to Jacksonville, FL is offered by FlixBus and takes 5h 10m. Bus tickets for this connection cost $45. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Jacksonville, FL?

The earliest bus arriving in Jacksonville, FL from Florence, SC starts at 9:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Jacksonville, FL?

The latest bus trip departing from Florence, SC for Jacksonville, FL starts at 4:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Jacksonville, FL route?

When traveling by bus from Florence, SC to Jacksonville, FL, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Jacksonville, FL?

You can check all the direct connections between Florence, SC and Jacksonville, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Jacksonville, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Jacksonville, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Jacksonville, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Jacksonville, FL on your planned travel date.

Available seat classes which are offered on the bus route Florence, SC to Jacksonville, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Jacksonville, FL

Here’s an overview of the most popular bus routes to Florence, SC and to Jacksonville, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!