Bus Chicago to Tupelo, MS - Compare all Companies

Compare all timetables for the bus from Chicago to Tupelo, MS

Here is a selection of the cheapest bus trips from the schedule from Chicago to Tupelo, MS from various bus operators like FlixBus or Greyhound US for the next days.

today

$101

tomorrow

Sunday

Monday

$99

Tuesday

Wednesday

$95

Thursday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	12h 10m	10:30 PM	Chicago	Downtown Bus Station	10:40 AM	Tupelo, MS	Bus Stop		Economy	$101	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 7/24/2026 10:30:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 7/25/2026 10:40:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 12h 10m
	FlixBus	13h 20m	9:45 AM	Chicago	Downtown Bus Station	11:05 PM	Tupelo, MS	Bus Stop		Economy	$102	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 7/24/2026 9:45:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 7/24/2026 11:05:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 13h 20m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	13h 20m	9:45 AM	Chicago	Downtown Bus Station	11:05 PM	Tupelo, MS	Bus Stop		Economy	$99	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 7/27/2026 9:45:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 7/27/2026 11:05:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 13h 20m
	Greyhound US	12h 10m	10:30 PM	Chicago	Downtown Bus Station	10:40 AM	Tupelo, MS	Bus Stop		Economy	$99	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 7/27/2026 10:30:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 7/28/2026 10:40:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 12h 10m

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	12h 10m	10:30 PM	Chicago	Downtown Bus Station	10:40 AM	Tupelo, MS	Bus Stop		Economy	$95	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 7/29/2026 10:30:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 7/30/2026 10:40:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 12h 10m
	FlixBus	13h 20m	9:45 AM	Chicago	Downtown Bus Station	11:05 PM	Tupelo, MS	Bus Stop		Economy	$97	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 7/29/2026 9:45:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 7/29/2026 11:05:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 13h 20m

Best Price Offer: The price for the cheapest bus from Chicago to Tupelo, MS is $77 on 8/9/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and Tupelo, MS

See here how frequent the connections between Chicago and Tupelo, MS are, during different times and days of the week.

Monday is the busiest day, with more than 2 daily buses from Chicago to Tupelo, MS. Monday has instead the fewest connections, with only 2 daily coaches between Chicago and Tupelo, MS.

The busiest time of the day is the Morning, with 3 buses from Chicago to Tupelo, MS, while Morning sees the fewest connections between Chicago and Tupelo, MS, with 3 offers.

Facts about the bus from Chicago to Tupelo, MS

Compare all providers like FlixBus and Greyhound US that travel 2 times every day by bus from Chicago to Tupelo, MS in one click! Book your bus ticket from Chicago to Tupelo, MS starting from $77!

Cheapest Bus	$77
Fastest Bus	12h 10m
Earliest Bus	9:45 AM
Latest Bus	10:30 PM
Daily Bus Routes	2 Ø
Distance	529.8 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Chicago to Tupelo, MS

Every day, 2 buses from 2 bus companies leave Chicago for Tupelo, MS: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/24/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

$101

Saturday 07/25

Sunday 07/26

$87

Monday 07/27

$99

Tuesday 07/28

$87

Wednesday 07/29

$95

Thursday 07/30

Friday 07/31

$79

Saturday 08/01

$111

Sunday 08/02

Monday 08/03

$95

Tuesday 08/04

$81

Wednesday 08/05

$99

Thursday 08/06

Friday 08/07

$93

Saturday 08/08

$91

Sunday 08/09

$77

Monday 08/10

$97

Tuesday 08/11

$87

Wednesday 08/12

$87

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from Chicago to Tupelo, MS

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Tupelo, MS, for the next 30 days.

With a price starting from $79, Friday is the cheapest day for a bus from Chicago to Tupelo, MS. Monday instead is the most expensive day with prices starting from $95.

Evening is the cheapest day time for bus tickets from Chicago to Tupelo, MS, with $95. Morning is the most expensive time of the day with prices starting from $97.

How to save money travelling from Chicago to Tupelo, MS

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Tupelo, MS in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Tupelo, MS, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Tupelo, MS are also emptier.

All bus stations and stops in Chicago and Tupelo, MS

In the map below, you can see where to find all bus stations in Chicago and Tupelo, MS.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Bus Stop

S Eason Blvd 2831

Service and Comfort on the bus from Chicago to Tupelo, MS

Want to know which seat classes are available on the buses from Chicago to Tupelo, MS? Or which bus companies serve the route Chicago to Tupelo, MS? Below you will find answers to your questions.

FAQs about the Chicago to Tupelo, MS bus

How much does a Chicago Tupelo, MS bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $77 and takes 12h 10m to reach Tupelo, MS. Compare offers to save money!

How much could I save by comparing buses from Chicago to Tupelo, MS?

This route is offered by 2 companies with a range of ticket prices between $77 and $102. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Tupelo, MS.

On average, how many connections are available from Chicago to Tupelo, MS each day?

Every day, the Chicago to Tupelo, MS bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Tupelo, MS take?

The fastest bus from Chicago to Tupelo, MS is offered by Greyhound US and takes 12h 10m. Bus tickets for this connection cost $101. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Tupelo, MS?

The earliest bus arriving in Tupelo, MS from Chicago starts at 9:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Tupelo, MS?

The latest bus trip departing from Chicago for Tupelo, MS starts at 10:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Tupelo, MS route?

When traveling by bus from Chicago to Tupelo, MS, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Tupelo, MS?

You can check all the direct connections between Chicago and Tupelo, MS by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Chicago to Tupelo, MS bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Tupelo, MS bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Tupelo, MS bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Tupelo, MS on your planned travel date.

Available seat classes which are offered on the bus route Chicago to Tupelo, MS

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Tupelo, MS

Here’s an overview of the most popular bus routes to Chicago and to Tupelo, MS. Simply click on the connection of your choice, and you will find all the details about your bus route!