Bus Buffalo, NY to Lake City, FL - Compare all Companies

Compare all timetables for the bus from Buffalo, NY to Lake City, FL

Here is a selection of the cheapest bus trips from the schedule from Buffalo, NY to Lake City, FL from various bus operators like Greyhound US or FlixBus for the next days.

today

$221

tomorrow

$212

Monday

$212

Tuesday

$212

Wednesday

Thursday

Friday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 5m	11:05 PM	Buffalo, NY	Central Bus Station	9:10 AM	Lake City, FL	Bus Stop	Economy	$221	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/25/2026 11:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 7/27/2026 9:10:00 AM. 50 Economy ticket for $221 per person are available. Travel duration is 34h 5m
Greyhound US	33h 20m	7:55 AM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$226	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/25/2026 7:55:00 AM to Bus Stop, Lake City, FL (USA) arriving at 7/26/2026 5:15:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 33h 20m
FlixBus	41h 16m	11:59 PM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$226	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 7/25/2026 11:59:00 PM to Bus Stop, Lake City, FL (USA) arriving at 7/27/2026 5:15:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 41h 16m

Did you know that if you travel from Buffalo, NY to Lake City, FL via Atlanta, GA, you can save more than $48? You can find the corresponding connections below.
- Greyhound US
  
  34h 5m
  
  0
  
  11:05 PM
  
  Buffalo, NY
  Central Bus Station
  
  10:00 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $111
  
  A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/26/2026 11:05:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 7/27/2026 10:00:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 22h 55m
- FlixBus
  
  8h 45m
  
  0
  
  12:25 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:10 AM
  
  Lake City, FL
  Bus Stop
  
  0
  
  Economy
  
  $62
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 7/28/2026 12:25:00 AM to Bus Stop, Lake City, FL (USA) arriving at 7/28/2026 9:10:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 8h 45m
Travel time is 0h 45m longer, but you will save $48

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	34h 5m	11:05 PM	Buffalo, NY	Central Bus Station	9:10 AM	Lake City, FL	Bus Stop		Economy	$212	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/26/2026 11:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 7/28/2026 9:10:00 AM. 50 Economy ticket for $212 per person are available. Travel duration is 34h 5m
	Greyhound US	33h 20m	7:55 AM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop		Economy	$219	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/26/2026 7:55:00 AM to Bus Stop, Lake City, FL (USA) arriving at 7/27/2026 5:15:00 PM. 50 Economy ticket for $219 per person are available. Travel duration is 33h 20m

Did you know that if you travel from Buffalo, NY to Lake City, FL via Atlanta, GA, you can save more than $49? You can find the corresponding connections below.
- Greyhound US
  
  33h 20m
  
  0
  
  7:55 AM
  
  Buffalo, NY
  Central Bus Station
  
  5:40 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $101
  
  A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/28/2026 7:55:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 7/29/2026 5:40:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 21h 45m
- FlixBus
  
  10h 15m
  
  0
  
  7:00 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  5:15 PM
  
  Lake City, FL
  Bus Stop
  
  0
  
  Economy
  
  $62
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 7/29/2026 7:00:00 AM to Bus Stop, Lake City, FL (USA) arriving at 7/29/2026 5:15:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 10h 15m
Travel time is the same as the direct connection, but you will save $49

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	41h 16m	11:59 PM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$212	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 7/27/2026 11:59:00 PM to Bus Stop, Lake City, FL (USA) arriving at 7/29/2026 5:15:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 41h 16m
Greyhound US	34h 5m	11:05 PM	Buffalo, NY	Central Bus Station	9:10 AM	Lake City, FL	Bus Stop	Economy	$223	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/27/2026 11:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 7/29/2026 9:10:00 AM. 50 Economy ticket for $223 per person are available. Travel duration is 34h 5m
Greyhound US	33h 20m	7:55 AM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$225	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/27/2026 7:55:00 AM to Bus Stop, Lake City, FL (USA) arriving at 7/28/2026 5:15:00 PM. 50 Economy ticket for $225 per person are available. Travel duration is 33h 20m

Did you know that if you travel from Buffalo, NY to Lake City, FL via Atlanta, GA, you can save more than $51? You can find the corresponding connections below.
- Greyhound US
  
  34h 5m
  
  0
  
  11:05 PM
  
  Buffalo, NY
  Central Bus Station
  
  10:00 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $101
  
  A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/28/2026 11:05:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 7/29/2026 10:00:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 22h 55m
- FlixBus
  
  8h 45m
  
  0
  
  12:25 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:10 AM
  
  Lake City, FL
  Bus Stop
  
  0
  
  Economy
  
  $60
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 7/30/2026 12:25:00 AM to Bus Stop, Lake City, FL (USA) arriving at 7/30/2026 9:10:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 8h 45m
Travel time is 0h 45m longer, but you will save $51

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 5m	11:05 PM	Buffalo, NY	Central Bus Station	9:10 AM	Lake City, FL	Bus Stop	Economy	$212	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/28/2026 11:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 7/30/2026 9:10:00 AM. 50 Economy ticket for $212 per person are available. Travel duration is 34h 5m
Greyhound US	33h 20m	7:55 AM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$214	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/28/2026 7:55:00 AM to Bus Stop, Lake City, FL (USA) arriving at 7/29/2026 5:15:00 PM. 50 Economy ticket for $214 per person are available. Travel duration is 33h 20m
FlixBus	41h 16m	11:59 PM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$279	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 7/28/2026 11:59:00 PM to Bus Stop, Lake City, FL (USA) arriving at 7/30/2026 5:15:00 PM. 50 Economy ticket for $279 per person are available. Travel duration is 41h 16m

Did you know that if you travel from Buffalo, NY to Lake City, FL via Tallahassee, FL, you can save more than $52? You can find the corresponding connections below.
- Greyhound US
  
  38h 25m
  
  0
  
  11:05 PM
  
  Buffalo, NY
  Central Bus Station
  
  10:50 AM
  
  Tallahassee, FL
  Greyhound Bus Station
  
  0
  
  Economy
  
  $135
  
  A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 7/29/2026 11:05:00 PM to Greyhound Bus Station, Tallahassee, FL (USA) arriving at 7/31/2026 10:50:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 35h 45m
- Greyhound US
  
  2h 5m
  
  0
  
  11:25 AM
  
  Tallahassee, FL
  Greyhound Bus Station
  
  1:30 PM
  
  Lake City, FL
  Bus Stop
  
  0
  
  Economy
  
  $25
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Tallahassee, FL (USA) at 7/31/2026 11:25:00 AM to Bus Stop, Lake City, FL (USA) arriving at 7/31/2026 1:30:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 2h 5m
Travel time is 5h 5m longer, but you will save $52

Best Price Offer: The price for the cheapest bus from Buffalo, NY to Lake City, FL is $212 on 7/27/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Buffalo, NY and Lake City, FL

See here how frequent the connections between Buffalo, NY and Lake City, FL are, during different times and days of the week.

Monday is the busiest day, with more than 3 daily buses from Buffalo, NY to Lake City, FL. Sunday has instead the fewest connections, with only 2 daily coaches between Buffalo, NY and Lake City, FL.

The busiest time of the day is the Evening, with 7 buses from Buffalo, NY to Lake City, FL, while Morning sees the fewest connections between Buffalo, NY and Lake City, FL, with 4 offers.

Facts about the bus from Buffalo, NY to Lake City, FL

Compare all providers like Greyhound US and FlixBus that travel 2 times every day by bus from Buffalo, NY to Lake City, FL in one click! Book your bus ticket from Buffalo, NY to Lake City, FL starting from $212!

Cheapest Bus	$212
Fastest Bus	33h 20m
Earliest Bus	7:55 AM
Latest Bus	11:59 PM
Daily Bus Routes	2 Ø
Distance	901.6 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Buffalo, NY to Lake City, FL

Every day, 2 buses from 2 bus companies leave Buffalo, NY for Lake City, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

Tuesday 07/21

Wednesday 07/22

Thursday 07/23

Friday 07/24

Saturday 07/25

Sunday 07/26

$212

Monday 07/27

$228

Tuesday 07/28

$212

Wednesday 07/29

Thursday 07/30

$225

Friday 07/31

Saturday 08/01

$229

Sunday 08/02

$212

Monday 08/03

$215

Tuesday 08/04

$242

Wednesday 08/05

$229

Thursday 08/06

$212

Friday 08/07

Saturday 08/08

$230

Sunday 08/09

Monday 08/10

Tuesday 08/11

$231

Wednesday 08/12

$215

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from Buffalo, NY to Lake City, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Buffalo, NY to Lake City, FL, for the next 30 days.

With a price starting from $212, Monday is the cheapest day for a bus from Buffalo, NY to Lake City, FL. Saturday instead is the most expensive day with prices starting from $221.

Evening is the cheapest day time for bus tickets from Buffalo, NY to Lake City, FL, with $212. Morning is the most expensive time of the day with prices starting from $214.

How to save money travelling from Buffalo, NY to Lake City, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Buffalo, NY to Lake City, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Buffalo, NY to Lake City, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Buffalo, NY to Lake City, FL are also emptier.

All bus stations and stops in Buffalo, NY and Lake City, FL

In the map below, you can see where to find all bus stations in Buffalo, NY and Lake City, FL.

Central Bus Station

Ellicott Street 181

MTC / Downtown Terminal

Ellicott Street 181

Maple Road Gulf

Maple Rd 4641

Asia Food Market

Niagara Falls Blvd 2055

Cleveland Hall

Bus Stop

S Marion Ave 251

Lake City Bus Stop

Service and Comfort on the bus from Buffalo, NY to Lake City, FL

Want to know which seat classes are available on the buses from Buffalo, NY to Lake City, FL? Or which bus companies serve the route Buffalo, NY to Lake City, FL? Below you will find answers to your questions.

FAQs about the Buffalo, NY to Lake City, FL bus

How much does a Buffalo, NY Lake City, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $212 and takes 41h 16m to reach Lake City, FL. Compare offers to save money!

How much could I save by comparing buses from Buffalo, NY to Lake City, FL?

This route is offered by 2 companies with a range of ticket prices between $212 and $279. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lake City, FL.

On average, how many connections are available from Buffalo, NY to Lake City, FL each day?

Every day, the Buffalo, NY to Lake City, FL bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Buffalo, NY to Lake City, FL take?

The fastest bus from Buffalo, NY to Lake City, FL is offered by Greyhound US and takes 33h 20m. Bus tickets for this connection cost $226. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Buffalo, NY to Lake City, FL?

The earliest bus arriving in Lake City, FL from Buffalo, NY starts at 7:55 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Buffalo, NY to Lake City, FL?

The latest bus trip departing from Buffalo, NY for Lake City, FL starts at 11:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Buffalo, NY Lake City, FL route?

When traveling by bus from Buffalo, NY to Lake City, FL, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Buffalo, NY and Lake City, FL?

You can check all the direct connections between Buffalo, NY and Lake City, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Buffalo, NY to Lake City, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Buffalo, NY Lake City, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Buffalo, NY Lake City, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Buffalo, NY to Lake City, FL on your planned travel date.

Available seat classes which are offered on the bus route Buffalo, NY to Lake City, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Buffalo, NY and to Lake City, FL

Here’s an overview of the most popular bus routes to Buffalo, NY and to Lake City, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!